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Susceptibility testing of Candida albicans and Candida glabrata to Glycyrrhiza glabra L.

2017Journal article Open access
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dc.contributor.authorMartins, Natália
dc.contributor.authorCosta-Oliveira, Sofia
dc.contributor.authorMelo, Luís D.R.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorAzeredo, Joana
dc.contributor.authorHenriques, Mariana
dc.contributor.authorSilva, Sónia
dc.creatorMartins N.
dc.date.accessioned2018-01-25T10:00:00Z
dc.date.accessioned2018-01-29T10:39:38Z
dc.date.available2018-01-25T10:00:00Z
dc.date.available2018-01-29T10:39:38Z
dc.date.issued2017
dc.description.abstractMedicinal plants and their botanical formulations have gained a pivotal attention among scientific researchers mainly due to its action as health promoters. Licorice (Glycyrrhiza glabra L.) constitutes a great example, with an increasingly evidenced antimicrobial potential. Opportunistic yeast infections constitute an alarming public health problem, highly exacerbated by the inefficacy of antifungal drugs and the increase of drug-resistant microorganisms, being Candida species one of the most common invaders. The present work aims to assess Candida glabrata and Candida albicans susceptibility to G. glabra methanol: water extract by using flow cytometry and transmission electron microscopy techniques. After 5 min, licorice extract (1.5 mg/mL) altered Candida membrane potential. Within an hour, it induced primary damages on Candida species cells, causing cell cytoplasm disorganization with high evidence of cell membrane invaginations, making cells turgid. Thus, based on the current findings, licorice extract seems to be a promising anti-Candida agent, without presenting any toxic potential at the effective concentrations used.pt_PT
dc.description.sponsorshipThe authors are grateful to Foundation for Science and Technology (FCT, Portugal) for N. Martins grant (SFRH/BD/87658/2012) and financial support to the research centre CIMO (strategic project PEst-OE/AGR/UI0690/2014). This work was also supported by the Programa Operacional, Fatores de competitividade – COMPETE and by national funds through FCT – Fundação para a Ciência e a Tecnologia on the scope of the projects FCT PTDC/SAU-MIC/119069/2010, RECI/EBB-EBI/0179/2012 and PEst-OE/EQB/LA0023/2013. The authors thank the Project “BioHealth – Biotechnology and Bioengineering approaches to improve health quality”, Ref. NORTE-07-0124-FEDER-000027, co-funded by the Programa Operacional Regional do Norte (ON.2–O Novo Norte), QREN, FEDER.
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMartins, Natália; Costa-Oliveira, Sofia; Melo, Luís D.R.; Ferreira, Isabel C.F.R.; Azeredo, Joana; Henriques, Mariana; Silva, Sónia (2017). Susceptibility testing of Candida albicans and Candida glabrata to Glycyrrhiza glabra L. Industrial Crops & Products. ISSN 0926-6690. 108, p. 480-484
dc.identifier.doi10.1016/j.indcrop.2017.07.008pt_PT
dc.identifier.issn09266690
dc.identifier.urihttp://hdl.handle.net/10198/15070
dc.language.isoeng
dc.peerreviewedyespt_PT
dc.relationPLANTAS MEDICINAIS A UTILIZAR EM FITOTERAPIA COMO ANTI-FÚNGICOS: EFEITO DE COMPOSTOS FENÓLICOS NO CRESCIMENTO DE ESPÉCIES DE CANDIDA EM SUSPENSÃO E EM BIOFILMES
dc.relationStrategic Project - UI 690 - 2014
dc.titleSusceptibility testing of Candida albicans and Candida glabrata to Glycyrrhiza glabra L.en_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitlePLANTAS MEDICINAIS A UTILIZAR EM FITOTERAPIA COMO ANTI-FÚNGICOS: EFEITO DE COMPOSTOS FENÓLICOS NO CRESCIMENTO DE ESPÉCIES DE CANDIDA EM SUSPENSÃO E EM BIOFILMES
oaire.awardTitleStrategic Project - UI 690 - 2014
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F87658%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0690%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/PTDC%2FSAU-MIC%2F119069%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/RECI%2FBBB-EBI%2F0179%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PEst-OE%2FEQB%2FLA0023%2F2013/PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamCOMPETE
oaire.fundingStreamCOMPETE
oaire.fundingStream3599-PPCDT
person.familyNameFerreira
person.givenNameIsabel C.F.R.
person.identifier144781
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticlept_PT
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