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Exploring the Chemopreventive and Antioxidant Effects of Spearmint Leaf Hydroethanolic Extract in HPV16-transgenic Mice

2025Journal article Restricted access
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datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg15:Proteger a Vida Terrestre
dc.contributor.authorJesus, Tiago M.
dc.contributor.authorAzevedo, Tiago
dc.contributor.authorSilva-Reis, Rita
dc.contributor.authorFerreira, Tiago
dc.contributor.authorNascimento-Gonçalves, Elisabete
dc.contributor.authorMedeiros, Catarina
dc.contributor.authorFerreira, João
dc.contributor.authorGama, Adelina
dc.contributor.authorGaivão, Isabel
dc.contributor.authorPires, Maria João
dc.contributor.authorLanzarin, Germano
dc.contributor.authorFélix, Luís
dc.contributor.authorVenância, Carlos
dc.contributor.authorMedeiros, Rui
dc.contributor.authorBastos, Margarida M.S.M.
dc.contributor.authorFinimundy, Tiane C.
dc.contributor.authorBarros, Lillian
dc.contributor.authorCosta, Rui M. Gil da
dc.contributor.authorOliveira, Paula A.
dc.date.accessioned2025-05-29T13:28:18Z
dc.date.available2025-05-29T13:28:18Z
dc.date.issued2025
dc.description.abstractHuman papillomavirus (HPV) is the most common sexually transmitted infectious agent and, in cases of persistent infection, may cause cancer. This study evaluated the toxicological and antitumor properties of Mentha spicata extract (MSE) in KP14HPV16 mice, which carry HPV16 oncogenes. Thirty‑three female FVB/n mice (Mus musculus), including 17 HPV‑transgenic and 16 wild‑type (WT) mice, were divided into six groups. The control groups received tap water (WT‑C, n=5, and HPV‑C, n=6), while the treatment groups received either 0.50 mg/ml MSE (WT‑50 and HPV‑50, n=6) or 0.55 mg/ml MSE (WT‑55 and HPV‑55, n=5) in drinking water for 28 days. Afterwards, animals were sacrificed, and blood and organs were collected for histopathological and biochemical analysis. The main phenolic compounds in MSE were rosmarinic acid and luteolin‑O‑glucoronide. MSE did not significantly affect weight gain in WT mice; however, WT‑55 gained significantly more weight than HPV‑55. MSE demonstrated antioxidant activity as indicated by the modulation of hepatic superoxide dismutase and glutathione S‑transferase (GST) activity, as well as renal GST activity, in MSE‑treated HPV groups. MSE did not reduce histological lesion incidence or systemic inflammation in HPV16‑transgenic mice. In general, while MSE was safe and exhibited antioxidant activity, it did not significantly impact HPV16‑induced lesions, warranting further research to assess systemic effects with different concentrations and durations.eng
dc.description.sponsorshipThis work was supported by national funds through FCT ‑ Portuguese Foundation for Science and Technology: CITAB (DOI: 10.54499/UIDB/04033/2020), Inov4Agro (DOI: 10.54499/LA/P/0126/2020); CECAV, DOI: 10.54499/ UIDB/00772/2020, AL4AnimalS (DOI: 10.54 499/LA/ P/0059/2020), CIMO (DOI: 10.54499/UIDB/ 00690/2020 and DOI: 10.54499/UIDP/00690/2020), SusTEC (DOI: 10.54499/LA/P/0007/2020), LEPABE (DOI: 10.54499/ UIDB/00511/2020 and DOI: 10.54499/UIDP/00511/ 2020), ALiCE (DOI: 10.54499/ LA/P/0045/2020). T.A., R.S.‑R. and T.F. thank FCT for the PhD grants 2023.01329.BD, 2022.14518.BD and 2020.04789.BD, respectively. National funding by FCT, P.I., through the scientific employment program‑contract for L.F. (CEEC‑IND, DOI: 10.54499/2021. 00458.CEECIND/ CP1690/CT0001) and L.B. (CEEC‑INST, DOI: 10.54499/ CEECINST/00107/2021/CP2793/CT0002).
dc.identifier.citationJesus, Tiago M.; Azevedo, Tiago; Silva-Reis, Rita; Ferreira, Tiago; Nascimento-Gonçalves, Elisabete; Medeiros, Catarina; Ferreira, João; Gama, Adelina; Gaivão, Isabel; Pires, Maria João; Lanzarin, Germano; Félix, Luís; Venância, Carlos; Medeiros, Rui; Bastos, Margarida M.S.M.; Finimundy, Tiane C.; Barros, Lillian; Costa, Rui M. Gil da; Oliveira, Paula A. (2025). Exploring the Chemopreventive and Antioxidant Effects of Spearmint Leaf Hydroethanolic Extract in HPV16-transgenic Mice. In Vivo. ISSN 0258-851X. 39:3, p. 1303-1313
dc.identifier.doi10.21873/invivo.13934
dc.identifier.eissn1791-7549
dc.identifier.issn0258-851X
dc.identifier.urihttp://hdl.handle.net/10198/34506
dc.language.isoeng
dc.peerreviewedyes
dc.publisherInternational Institute of Anticancer Research
dc.relationCentre for the Research and Technology of Agro-Environmental and Biological Sciences
dc.relationInstitute for innovation, capacity building and sustainability of agri-food production
dc.relationVeterinary and Animal Science Research Centre
dc.relationAssociate Laboratory for Animal and Veterinary Sciences
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.relationAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
dc.relationLaboratory for Process Engineering, Environment, Biotechnology and Energy
dc.relationMenthol and Thymol loaded in mucoadhesive nanocapsules for the transportation of ornamental fish
dc.relationALICE - Associate Laboratory in Chemical Engineering
dc.relationLaboratory for Process Engineering, Environment, Biotechnology and Energy
dc.relation.ispartofIn Vivo
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectNatural compounds
dc.subjectHPV
dc.subjectoxidative stress
dc.subjectgenotoxicity
dc.subjectanimal model
dc.titleExploring the Chemopreventive and Antioxidant Effects of Spearmint Leaf Hydroethanolic Extract in HPV16-transgenic Miceeng
dc.typejournal article
dspace.entity.typePublication
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oaire.citation.endPage1313
oaire.citation.issue3
oaire.citation.startPage1303
oaire.citation.titleIn Vivo
oaire.citation.volume39
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person.familyNameFinimundy
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person.givenNameTiane C.
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