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Genomic and phenotypic characterization of Enterococcus faecalis from broiler sternal bursitis: antimicrobial resistance and one health risks

2026Artigo científico Acesso aberto
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datacite.subject.fosCiências Naturais::Ciências Biológicas
datacite.subject.fosCiências Agrárias::Biotecnologia Agrária e Alimentar
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg02:Erradicar a Fome
datacite.subject.sdg12:Produção e Consumo Sustentáveis
datacite.subject.sdg04:Educação de Qualidade
dc.contributor.authorRibeiro, Jessica
dc.contributor.authorSilva, Vanessa
dc.contributor.authorPinto, Pedro
dc.contributor.authorVieira-Pinto, Madalena
dc.contributor.authorBatista, Rita
dc.contributor.authorNunes, Alexandra
dc.contributor.authorGomes, João Paulo
dc.contributor.authorIgrejas, Gilberto
dc.contributor.authorBarros, Lillian
dc.contributor.authorHeleno, Sandrina A.
dc.contributor.authorReis, Filipa S.
dc.contributor.authorPoeta, Patrícia
dc.date.accessioned2026-03-20T15:16:06Z
dc.date.available2026-03-20T15:16:06Z
dc.date.issued2026
dc.description.abstractEnterococcus spp. are opportunistic bacteria capable of acquiring antimicrobial resistance and virulence traits, facilitating their adaptation to multiple ecological niches. Sternal bursitis, a condition affecting poultry welfare and carcass quality, remains poorly characterized from a microbiological perspective. This study provides the first genomic and phenotypic characterization of Enterococcus isolates from bursitis lesions in broilers, aiming to assess their antimicrobial resistance profiles, virulence determinants, and genetic diversity within a One Health framework. A total of 44 Enterococcus isolates were recovered from 48 sternal bursitis lesions, all identified as E. faecalis. Resistance was common for tetracycline (70.5%) and erythromycin (27.3%), while all isolates remained susceptible to critically important antimicrobials, including vancomycin and linezolid. Whole genome sequencing revealed a genetically diverse population, comprising multiple sequence types, plasmid replicons, and virulence gene profiles, including determinants for adhesion, biofilm formation, capsule synthesis, and extracellular proteases. Ionophore resistance genes (narA, narB) were also detected in several lineages. The coexistence of antimicrobial resistance and virulence determinants, often linked to mobile genetic elements, highlights the potential of lesion-associated with E. faecalis to act as reservoirs of relevant genes with zoonotic implications. Overall, this work highlights the diverse and ecological role of Enterococcus in extraintestinal poultry infections, reinforcing the need for continued genomic surveillance to promote animal health, food safety, and antimicrobial stewardship.eng
dc.description.sponsorshipOpen access funding provided by FCT|FCCN (b-on). This work was supported by the Portuguese Foundation for Science and Technology (FCT) through projects UIDB/CVT/00772/2020 (DOI:https://doi.org/10.54499/UIDB/00772/2020) and LA/P/0059/2020. Also, it was supported by national funds through FCT/MCTES (PIDDAC): CIMO, UID/00690/2025 (DOI:https://doi.org/10.54499/UID/00690/2025) and UID/PRR/00690/2025 (DOI:https://doi.org/10.54499/UID/PRR/00690/2025); and the SusTEC, LA/P/0007/2020 (DOI:https://doi.org/10.54499/LA/P/0007/2020). Jessica Ribeiro acknowledges financial support from FCT for her doctoral fellowship (2023.00592.BD). The authors also thank FCT for support through employment contracts, including the institutional contract awarded to S. A. Heleno and the individual scientific employment contract held by F. S. Reis (2021.03728.CEECIND).
dc.identifier.citationRibeiro, Jessica; Silva, Vanessa; Pinto, Pedro; Vieira-Pinto, Madalena; Batista, Rita; Nunes, Alexandra; Gomes, João Paulo; Igrejas, Gilberto; Barros, Lillian; Heleno, Sandrina A.; Reis, Filipa S.; Poeta, Patrícia (2026). Genomic and phenotypic characterization of Enterococcus faecalis from broiler sternal bursitis: antimicrobial resistance and one health risks. Veterinary Research Communications. INSS 0165-7380. 50:3, p. 1-12
dc.identifier.doi10.1007/s11259-026-11100-y
dc.identifier.issn0165-7380
dc.identifier.issn1573-7446
dc.identifier.urihttp://hdl.handle.net/10198/36178
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer Nature
dc.relationVeterinary and Animal Science Research Centre
dc.relationAssociate Laboratory for Animal and Veterinary Sciences
dc.relationMountain Research Center
dc.relationAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
dc.relationCYPonins: Cypress saponins as a possible bio-based alternative to address high-mortality rate tumours
dc.relation.ispartofVeterinary Research Communications
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectEnterococcus faecalis
dc.subjectBroiler chickens
dc.subjectSternal bursitis
dc.subjectAntimicrobial resistance
dc.subjectVirulence factors
dc.titleGenomic and phenotypic characterization of Enterococcus faecalis from broiler sternal bursitis: antimicrobial resistance and one health riskseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberUIDP/00772/2020
oaire.awardNumberLA/P/0059/2020
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oaire.awardNumberLA/P/0007/2020
oaire.awardNumber2021.03728.CEECIND/CP1677/CT0001
oaire.awardTitleVeterinary and Animal Science Research Centre
oaire.awardTitleAssociate Laboratory for Animal and Veterinary Sciences
oaire.awardTitleMountain Research Center
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oaire.awardTitleCYPonins: Cypress saponins as a possible bio-based alternative to address high-mortality rate tumours
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00772%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0059%2F2020/PT
oaire.awardURIhttp://hdl.handle.net/10198/35759
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0007%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND4ed/2021.03728.CEECIND%2FCP1677%2FCT0001/PT
oaire.citation.endPage12
oaire.citation.issue3
oaire.citation.startPage1
oaire.citation.titleVeterinary Research Communications
oaire.citation.volume50
oaire.fundingStream6817 - DCRRNI ID
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oaire.fundingStreamCIMO
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamCEEC IND4ed
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
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project.funder.nameFundação para a Ciência e a Tecnologia
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