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New Pickering emulsions stabilized with chitosan/collagen peptides nanoparticles: Synthesis, characterization and tracking of the nanoparticles after skin application

2021Journal article Open access
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dc.contributor.authorSharkawy, Asma
dc.contributor.authorBarreiro, M.F.
dc.contributor.authorRodrigues, Alírio
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2021-11-23T11:27:54Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2021-11-23T11:27:54Z
dc.date.issued2021
dc.description.abstractPickering emulsions based on biopolymeric particles are gaining increasing research recognition in numerous applications due to their biocompatibility and eco-friendliness. In this work, chitosan/collagen peptides nanoparticles were applied to stabilize Pickering emulsions for potential cosmetic applications. The nanoparticles had a contact angle of 78.02° ± 2.04°, reflecting their hydrophilic nature. Their average size and zeta potential were 32.27 nm and +59.7 mV, respectively. Confocal laser scanning microscopy (CLSM) showed that the nanoparticles become well-adsorbed at the oil-water interface. The emulsions displayed shear-thinning viscosity and gel-like texture. Their average droplet size ranged between 7.63 μm and 15.72 μm. CLSM skin tracking of the nanoparticles, after ex vivo skin application of the Pickering emulsions, revealed the ability of the emulsion droplets to penetrate the stratum corneum and deposit in deeper skin layers. The penetration degree depends on the concentration of the nanoparticles in the emulsion and on the contact time with the skin. These results provide new insights into the fate of the nanoparticles used to stabilize Pickering emulsions following their skin application.en_EN
dc.description.sponsorshipThis work was financially supported by the Base Funding—UIDB/50020/2020 of the Associate Laboratory LSRE-LCM—funded by national funds through FCT/MCTES (PIDDAC). The work was also supported by the Base Funding—(UIDB/00690/2020) of CIMO—Centro de Investigação de Montanha—funded by national funds through FCT/ MCTES (PIDDAC). The authors gratefully acknowledge the technical support provided by the Instituto de Investigaç˜ao e Inovação (i3s) at the University of Porto. Asma Sharkawy gratefully thanks the Foundation for Science and Technology (FCT, Portugal) for the doctoral grant (PD/BD/135085/2017), and Dr. Rui Faria from the LSRE-LCM (University of Porto) for the invaluable discussion.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationSharkawy, Asma; Barreiro, Maria Filomena; Rodrigues, Alírio E. (2021). New Pickering emulsions stabilized with chitosan/collagen peptides nanoparticles: Synthesis, characterization and tracking of the nanoparticles after skin application. Colloids and Surfaces A: Physicochemical and Engineering Aspects. ISSN 0927-7757. 616, p.en_EN
dc.identifier.doi10.1016/j.colsurfa.2021.126327en_EN
dc.identifier.issn09277757
dc.identifier.urihttp://hdl.handle.net/10198/24345
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
dc.relationMountain Research Center
dc.relationDevelopment and characterization of encapsulation systems for the protection and controlled release of active agents
dc.subjectChitosan/collagen peptidesen_EN
dc.subjectEmulsion stabilityen_EN
dc.subjectNanoparticles trackingen_EN
dc.subjectPickering emulsionsen_EN
dc.subjectRheologyen_EN
dc.subjectSkin applicationsen_EN
dc.titleNew Pickering emulsions stabilized with chitosan/collagen peptides nanoparticles: Synthesis, characterization and tracking of the nanoparticles after skin applicationen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
oaire.awardTitleMountain Research Center
oaire.awardTitleDevelopment and characterization of encapsulation systems for the protection and controlled release of active agents
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50020%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//PD%2FBD%2F135085%2F2017/PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameBarreiro
person.givenNameFilomena
person.identifier.ciencia-id3418-47D5-5746
person.identifier.orcid0000-0002-6844-333X
person.identifier.ridL-9802-2014
person.identifier.scopus-author-id57188719717
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
relation.isAuthorOfPublication0391987c-ba90-488b-839a-153447ce1f0f
relation.isAuthorOfPublication.latestForDiscovery0391987c-ba90-488b-839a-153447ce1f0f
relation.isProjectOfPublication79ed495f-40dc-45d0-b98c-7e777db59e9b
relation.isProjectOfPublication29718e93-4989-42bb-bcbc-4daff3870b25
relation.isProjectOfPublicationd087c3c1-864a-4c31-9ea9-96907c8a2511
relation.isProjectOfPublication.latestForDiscovery79ed495f-40dc-45d0-b98c-7e777db59e9b

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