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Anti-Proliferative, Anti-Inflammatory, In Vitro Wound Healing Potentials and Phenolic Content of Phlomis Crinita Cav. Extracts

2025Journal article Restricted access
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datacite.subject.fosCiências Naturais::Ciências da Terra e do Ambiente
datacite.subject.fosCiências Naturais::Ciências Biológicas
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg12:Produção e Consumo Sustentáveis
dc.contributor.authorChelgham, Abdelhakim
dc.contributor.authorBorges, Ana Margarida
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorMerouane, Abdelaziz
dc.contributor.authorNoui, Abdallah
dc.contributor.authorSaadi, Abdelkader
dc.date.accessioned2025-05-30T08:41:40Z
dc.date.available2025-05-30T08:41:40Z
dc.date.issued2025
dc.description.abstractPhlomis crinita Cav. (P. crinita), a medicinal plant from the Lamiaceae family, is widely used as a natural remedy in traditional North African and Southern European folk medicine to treat lesions and burns through the application of its leaves This study aimed to investigate its biological activities, including antiproliferative, anti-inflammatory, and wound-healing properties. Hydromethanolic extracts were prepared from the leaves, flowers, and rhizomes. Phytochemical analysis determined total phenolic content (TPC) and flavonoid content (FC). Antiproliferative activity was evaluated using the sulforhodamine B (SRB) assay against five human tumor cell lines (AGS, Caco-2, HeLa, MCF-7, and NCI-H460), each derived from a carcinoma of a distinct organ. Anti-inflammatory activity was assessed by measuring nitric oxide production in LPS-stimulated RAW 264.7 macrophages. The wound-healing potential was evaluated using the scratch assay. Phytochemical analysis revealed significant variations in TPC and FC among the extracts, with the rhizome extract exhibiting the highest levels: TPC: 128.15 μg GAE/mg DW and FC: 46.91 μg QE/mg DW. All extracts demonstrated antiproliferative activity against the tumor cell lines, with the rhizome extract showing the most potent growth inhibition (GI50: 178.11 ± 4.10 μg/mL against AGS). The rhizome extract also exhibited the most potent inhibition of nitric oxide production (IC50: 152.42 ± 10.88 μg/mL) compared to the other extracts tested. In the wound-healing assay, leaf extract demonstrated comparable healing effects to Allantoin, a known wound-healing agent. Our findings support the notion that P. crinita can be considered a promising source of therapeutic bioactive compounds.eng
dc.identifier.citationChelgham, Abdelhakim; Borges, Ana Margarida; Calhelha, Ricardo C.; Merouane, Abdelaziz; Noui, Abdallah; Saadi, Abdelkader (2025). Anti-Proliferative, Anti-Inflammatory, In Vitro Wound Healing Potentials and Phenolic Content of Phlomis Crinita Cav. Extracts. Tropical Journal of Natural Product Research. ISSN 2616-0684. 9:3, p. 985-991
dc.identifier.doi10.26538/tjnpr/v9i3.13
dc.identifier.issn2616-0684
dc.identifier.urihttp://hdl.handle.net/10198/34520
dc.language.isoeng
dc.peerreviewedyes
dc.publisherFaculty of Pharmacy, University of Benin
dc.relation.ispartofTropical Journal of Natural Product Research
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectPhlomis crinita
dc.subjectHerbal medicine
dc.subjectCancer cell line
dc.subjectAnti-inflammatory potential
dc.subjectWound healing potential
dc.subjectPhenolic compounds
dc.titleAnti-Proliferative, Anti-Inflammatory, In Vitro Wound Healing Potentials and Phenolic Content of Phlomis Crinita Cav. Extractseng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage991
oaire.citation.issue3
oaire.citation.startPage985
oaire.citation.titleTropical Journal of Natural Product Research
oaire.citation.volume9
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameBorges
person.familyNameCalhelha
person.givenNameAna Margarida
person.givenNameRicardo C.
person.identifier.ciencia-idCA13-636E-7820
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.orcid0009-0009-8809-0541
person.identifier.orcid0000-0002-6801-4578
person.identifier.ridJ-2172-2014
person.identifier.scopus-author-id6507978333
relation.isAuthorOfPublication85ec5de9-4999-4dda-9787-fe10250a6af5
relation.isAuthorOfPublication2d5d1a41-7561-4a01-871c-b4c97da35053
relation.isAuthorOfPublication.latestForDiscovery85ec5de9-4999-4dda-9787-fe10250a6af5

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