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Merlot grape pomace hydroalcoholic extract improves the oxidative and inflammatory states of rats with adjuvant-induced arthritis

2017Journal article Open access
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dc.contributor.authorGonçalves, Geferson A.
dc.contributor.authorSoares, Andréia A.
dc.contributor.authorCorrêa, Rúbia C.G.
dc.contributor.authorBarros, Lillian
dc.contributor.authorHaminiuk, Charles Windson Isidoro
dc.contributor.authorPeralta, Rosane M.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorBracht, Adelar
dc.date.accessioned2018-01-25T10:00:00Z
dc.date.accessioned2018-01-30T15:00:22Z
dc.date.available2018-01-25T10:00:00Z
dc.date.available2018-01-30T15:00:22Z
dc.date.issued2017
dc.description.abstractGrape pomace is an agro-industrial residue produced worldwide. The purpose of this study was to identify and quantify the main phenolics present in an hydroalcohlic extract of a Merlot grape pomace and to investigate its effect on the oxidative and inflammatory states of adjuvant-induced arthritic rats. Daily doses of 250 mg of the extract per kg body weight were administered during 23 days. Several oxidative stress indicators in arthritic rats were maintained at their normal or closely normal levels in the plasma, liver and brain by the treatment. Additionally, the grape pomace also showed significant anti-inflammatory effects. From the 25 phenolics identified in the grape pomace extract the most abundant ones were catechin and catechin derivatives, which are possibly the most important antioxidant agents. The results suggest a potential applicability of the Merlot grape pomace hydroalcoholic extract in the improvement of the oxidative and inflammatory states in arthritic patients.pt_PT
dc.description.sponsorshipThe authors which to thank Anacharis Babeto de Sá-Nakanishi, Jurandir Fernando Comar and Leomara Floriano Ribeiro for their expert technical assistance. This work was financially supported by grants from the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Proc. 302615/2011-3 and Proc. 307944/2015-8) and Fundação Araucária (Proc. 215/2014). Andréia A. Soares and Rúbia C. G. Corrêa were post-doc fellowship recipients of the Coordenação do Aperfeiçoamento de Pessoal do Ensino Superior (CAPES) and Fundação Araucária. The authors are also thankful to the Foundation for Science and Technology (FCT, Portugal) and FEDER under Program PT2020 for financial support to CIMO (UID/AGR/00690/2013) and L. Barros (SFRH/BPD/107855/2015) grant. To POCI-01-0145-FEDER-006984 (LA LSRE-LCM), funded by ERDF, through POCI-COMPETE2020 and FCT.
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGonçalves, Geferson A.; Soares, Andréia A.; Correa, Rúbia C.G.; Barros, Lillian; Haminiuk, Charles W.I.; Peralta, Rosane M.; Ferreira, Isabel C.F.R.; Bracht, Adelar (2017). Merlot grape pomace hydroalcoholic extract improves the oxidative and inflammatory states of rats with adjuvant-induced arthritis. Journal of Functional Foods. ISSN 1756-4646. 33, p. 408-418en_EN
dc.identifier.doi10.1016/j.jff.2017.04.009pt_PT
dc.identifier.issn1756-4646
dc.identifier.urihttp://hdl.handle.net/10198/15291
dc.language.isoeng
dc.peerreviewedyespt_PT
dc.relation006984
dc.subjectArthritisen_EN
dc.subjectGrape pomaceen_EN
dc.subjectInflammationen_EN
dc.subjectOxidative stressen_EN
dc.subjectPolyphenolicsen_EN
dc.subjectProtein damageen_EN
dc.titleMerlot grape pomace hydroalcoholic extract improves the oxidative and inflammatory states of rats with adjuvant-induced arthritisen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/PEst-OE%2FSAU%2FUI0215%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAGR%2F00690%2F2013/PT
oaire.fundingStream5876
oaire.fundingStream5876
person.familyNameCorrêa
person.familyNameBarros
person.familyNameFerreira
person.givenNameRúbia C.G.
person.givenNameLillian
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifier144781
person.identifier.ciencia-id6C1F-2818-CBB5
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0003-0269-4344
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-3600-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id37661286600
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticlept_PT
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relation.isAuthorOfPublication3af07ffe-f914-48ba-a5d5-efcf70fdce01
relation.isAuthorOfPublicationbd0d1537-2e03-41fb-b27a-140af9c35db8
relation.isAuthorOfPublication.latestForDiscoverybd0d1537-2e03-41fb-b27a-140af9c35db8
relation.isProjectOfPublication10897f98-57cb-4191-b678-90bbfe81b51e
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