Repository logo
 
Publication

Antimicrobial and wound healing effects associated to cytocompatibility and the relationship with phytochemical profile of selected Portuguese monofloral honeys

2025Journal article Open access
Simple item page
datacite.subject.fosCiências Agrárias::Agricultura, Silvicultura e Pescas
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg12:Produção e Consumo Sustentáveis
dc.contributor.authorMachado, Alexandra M.
dc.contributor.authorMarto, Joana
dc.contributor.authorGonçalves, Lídia Maria
dc.contributor.authorRibeiro, Helena Margarida
dc.contributor.authorDuarte, Aida
dc.contributor.authorTomás, Andreia
dc.contributor.authorFalcão, Soraia
dc.contributor.authorVilas-Boas, Miguel
dc.contributor.authorMiguel, Maria Graça
dc.contributor.authorFigueiredo, Ana Cristina
dc.date.accessioned2025-06-02T14:21:35Z
dc.date.available2025-06-02T14:21:35Z
dc.date.issued2025
dc.description.abstractOwing to its applications in both food and pharmaceutical industries honey is regarded as a functional product. This study evaluated 32 Portuguese monofloral honeys and their activity was compared with manuka honey 850 + . The antimicrobial activity was determined against Gram-positive and negative bacteria, and yeast. Antioxidant activity, wound healing ability, and cell viability were studied in the human keratinocyte cell line (HaCaT). Phytochemical profile analysis was performed by UPLC/DAD/ESI-MSn. Chestnut, bell heather, eucalyptus, manuka, and strawberry tree honeys demonstrated higher antioxidant activity and were effective against S. aureus. Incense and orange honeys showed wound healing rates of 89 % and 86 %, respectively. All the honeys had cell viability above 76 %. Bell heather and strawberry tree honeys showed the highest total phenolic content, while incense and orange honeys, showed the lower ones. Phytochemical profile analysis evidenced two main clusters, one dominated by isoprenoids and norisoprenoids, as well as phenolic acids and derivatives, while the other included flavonoids as main compounds. Blending different Portuguese monofloral honeys may be an alternative to faster wound healing, by combining their diverse bioactive components. The gathered knowledge can be further explored in formulations that consider the biological activity capacity and composition of each honey.eng
dc.description.sponsorshipThanks to Fundação para a Ciência e a Tecnologia (FCT) for the PhD grant SFRH/BD/117013/2016 to Alexandra M. Machado, the grant CEECINST/00145/2018 to Joana Marto, the principal investigator grant CEECIND/03143/2017 to Lídia Maria Gonçalves, and through the institutional scientific employment program-contract with Soraia I. Falcão. We acknowledge the financial support to FCT/MCTES through national funds, under CESAM UIDB/50017/2020, DOI 10.54499/UIDB/50017/2020+ UIDP/50017/2020, DOI 10.54499/UIDP/50017/2020+LA/P/0094/2020, DOI 10.54499/LA/P/0094/2020, CIMO, UIDB/00690/2020 (DOI: 10.54499/UIDB/00690/2020) and UIDP/00690/2020 (DOI: 10.54499/UIDP/00690/2020); and SusTEC, LA/P/0007/2020 (DOI: 10.54499/LA/P/0007/2020), MED (https://doi.org/10.54499 UIDB/05183/2020;https://doi.org/10.54499/UIDP/05183/202) and CHANGE (https://doi.org/10.54499/LA/P/0121/2020), UID 04138 - Instituto de Investigação do Medicamento, to FEDER and PT2020 PACompete 2020, project GreenHealth, Norte-01–0145-FEDER-000042 and UID/00329/2025 - Centre for Ecology, Evolution andEnvironmental Changes (CE3C) & CHANGE – Global Change and Sustainability Institute.
dc.identifier.citationMachado, Alexandra M.; Marto, Joana; Gonçalves, Lídia Maria; Ribeiro, Helena Margarida; Duarte, Aida; Tomás, Andreia; Falcão, Soraia; Vilas-Boas, Miguel; Miguel, Maria Graça; Figueiredo, Ana Cristina. (2025). Antimicrobial and wound healing effects associated to cytocompatibility and the relationship with phytochemical profile of selected Portuguese monofloral honeys. Journal of Food Composition and Analysis. ISSN 0889-1575. 144, p. 1-11
dc.identifier.doi10.1016/j.jfca.2025.107659
dc.identifier.issn0889-1575
dc.identifier.urihttp://hdl.handle.net/10198/34542
dc.language.isoeng
dc.peerreviewedyes
dc.publisherAcademic Press Inc.
dc.relationVolatile chemical characterization and biological activity assessment of Portuguese honey types – importance of botanical origin
dc.relationSFRH/BD/117013/2016
dc.relationNot Available
dc.relationNot Available
dc.relationCentre for Environmental and Marine Studies
dc.relationCentre for Environmental and Marine Studies
dc.relation.ispartofJournal of Food Composition and Analysis
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectPortuguese monofloral honeys
dc.subjectBioactivity
dc.subjectPhytochemical profile
dc.subjectUPLC/DAD/ESI-MSn
dc.titleAntimicrobial and wound healing effects associated to cytocompatibility and the relationship with phytochemical profile of selected Portuguese monofloral honeyseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleVolatile chemical characterization and biological activity assessment of Portuguese honey types – importance of botanical origin
oaire.awardTitleNot Available
oaire.awardTitleNot Available
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F117013%2F2016/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F117013%2F2016/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC INST 2018/CEECINST%2F00145%2F2018%2FCP1571%2FCT0001/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F03143%2F2017%2FCP1476%2FCT0005/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50017%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50017%2F2020/PT
oaire.citation.endPage11
oaire.citation.startPage1
oaire.citation.titleJournal of Food Composition and Analysis
oaire.citation.volume144
oaire.fundingStreamOE
oaire.fundingStreamCEEC INST 2018
oaire.fundingStreamCEEC IND 2017
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameTomás
person.familyNameFalcão
person.familyNameVilas-Boas
person.givenNameAndreia
person.givenNameSoraia
person.givenNameMiguel
person.identifier711432
person.identifier1693134
person.identifier.ciencia-id1C1B-8981-E49E
person.identifier.ciencia-idD41A-6BED-4CBB
person.identifier.ciencia-idA918-C6FF-81A4
person.identifier.orcid0000-0003-3735-6951
person.identifier.orcid0000-0002-8665-5280
person.identifier.ridI-5949-2013
person.identifier.scopus-author-id14832459200
person.identifier.scopus-author-id6602648497
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isAuthorOfPublication9cb298ef-31c6-4761-8842-b842e46dca0f
relation.isAuthorOfPublication5746ab3e-8ffe-4e26-9a41-8392cf031f28
relation.isAuthorOfPublicationf58280c8-298b-4e4c-9f7c-4517300d3382
relation.isAuthorOfPublication.latestForDiscovery5746ab3e-8ffe-4e26-9a41-8392cf031f28
relation.isProjectOfPublicationac3b1db2-1fa2-4463-9651-7255692bb529
relation.isProjectOfPublication8f2de805-c59e-4b4e-a5bb-15acf57946cd
relation.isProjectOfPublicationda937156-28d3-4e50-b793-c1cd2c94ffac
relation.isProjectOfPublication17719b76-18b1-4ea0-8bce-a4f40dbdf84c
relation.isProjectOfPublication38b82779-9060-417b-85cc-9780fc94d1ff
relation.isProjectOfPublicationf485cb82-0f0d-4378-bbd7-3113508539fd
relation.isProjectOfPublication.latestForDiscoveryac3b1db2-1fa2-4463-9651-7255692bb529

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
1-s2.0-S0889157525004740-main.pdf
Size:
1.92 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.75 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

CIMO - Artigos em Revistas Indexados à WoS/Scopus