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Valorization of pumpkin peel as a source of bioactive compounds: optimization of heat- and ultrasound-assisted extraction

2023Journal article Open access
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dc.contributor.authorLeichtweis, Maria Gabriela
dc.contributor.authorMolina, Adriana K.
dc.contributor.authorPetropoulos, Spyridon Α.
dc.contributor.authorCarocho, Márcio
dc.contributor.authorPires, Tânia C.S.P.
dc.contributor.authorDias, Maria Inês
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorOliveira, Beatriz
dc.contributor.authorPereira, Carla
dc.contributor.authorBarros, Lillian
dc.date.accessioned2020-04-15T13:31:34Z
dc.date.available2020-04-15T13:31:34Z
dc.date.issued2023
dc.description.abstractThe peels from three pumpkin genotypes cultivated in Greece were assessed for their phenolic content and bioactive properties to obtain extracts with a high preservative capacity. The optimization of the extraction was performed through response surface methodology (RSM) based on a Box-Behnken experimental design after applying two extraction techniques: heat-assisted (HAE) and ultrasound-assisted (UAE) extraction. The implemented independent variables were time, solvent concentration, and temperature/power (for HAE/UAE), while as dependent variables the dry residue (DR), reducing power (RP), and total phenolic content (TP) were considered. In general, HAE was the most effective technique for 'TL' (75 min; 30 degrees C; 24% ethanol) and 'Voutirato' (15 min; 30 degrees C; 10% ethanol), while UAE was more effective for 'Leuka Melitis' (5 min; 400 W; 0% ethanol). The extracts obtained in the global optimum conditions for each genotype peel were then assessed for their phenolic profile, by HPLC-DAD-ESI/MS, and bioactive potential. Seven phenolic compounds were detected, including four flavonoids, two phenolic acids, and one flavan-3-ol. The extracts presented high antioxidant, antibacterial, and antifungal potential, with no cytotoxicity for non-tumor cells. The optimized conditions for the extraction of preservative compounds from bioresidues were defined, allowing the acquisition of antioxidant and antimicrobial extracts and proving their potential for food application.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLeichtweis, Maria Gabriela; Molina, Adriana K.; Petropoulos, Spyridon Α.; Carocho, Márcio; Pires, Tânia C.S.P.; Dias, Maria Inês; Calhelha, Ricardo C.; Oliveira, M. Beatriz P. P.; Pereira, Carla; Barros, Lillian (2023). Valorization of pumpkin peel as a source of bioactive compounds: optimization of heat- and ultrasound-assisted extraction. Molecules. eISSN 1420-3049. 28:7, p. 1-22pt_PT
dc.identifier.doi10.3390/molecules28073168
dc.identifier.eissn1420-3049
dc.identifier.urihttp://hdl.handle.net/10198/21650
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPI
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCucurbita maxima Duchesnept_PT
dc.subjectNatural food preservativespt_PT
dc.subjectProcess optimizationpt_PT
dc.subjectPhenolic compoundspt_PT
dc.subjectPumpkin peel
dc.subjectBioactivity
dc.subjectRSM
dc.titleValorization of pumpkin peel as a source of bioactive compounds: optimization of heat- and ultrasound-assisted extractionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleMoleculespt_PT
person.familyNameLeichtweis
person.familyNameMolina
person.familyNameCarocho
person.familyNamePires
person.familyNameDias
person.familyNameCalhelha
person.familyNamePereira
person.familyNameBarros
person.givenNameMaria Gabriela
person.givenNameAdriana K.
person.givenNameMárcio
person.givenNameTânia C.S.P.
person.givenNameMaria Inês
person.givenNameRicardo C.
person.givenNameCarla
person.givenNameLillian
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person.identifier2118829
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person.identifier.orcid0000-0003-0093-771X
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridQ-2842-2018
person.identifier.ridM-8242-2013
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person.identifier.scopus-author-id52463229800
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person.identifier.scopus-author-id6507978333
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rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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