Repository logo
 
Publication

Development of paraben-free hydrogel based on plant extracts for topical application

2013Conference object Open access
Simple item page
dc.contributor.authorBarreira, João C.M.
dc.contributor.authorRodrigues, Sandra
dc.contributor.authorCarvalho, Ana Maria
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2013-09-06T09:08:29Z
dc.date.available2013-09-06T09:08:29Z
dc.date.issued2013
dc.description.abstractHistorically, medicinal preparations are derived from plants and their employment in dermatological and cosmetic products is increasing [1]. Topical application of products containing compounds with free radical scavenging properties protects tissues from oxidative damage [2]. The skin is an important protective barrier between the environment and the inner milieu, being highly exposed to oxidative stress, either from exogenous as well as endogenous sources [3]. The antioxidant potential of herbal extracts or pure isolated compounds have been extensively studied, but very few reports are available on the antioxidant properties of final formulations in which they have been included. In the present study, aqueous and ethanolic extracts from the flower buds of hawthorn (Crataegus monogyna Jacq.) were incorporated into hydrosoluble gels. Gels have been largely used in cosmetic products and as a dermatologic base, as they are easily dispersed, nonoily and can carry hydrosoluble active principles. Gel consistency was optimized when carbopol 940 was added at 1%. The prepared formulations presented a light green colour, a non-greasy texture and were promptly absorbed by the skin. Since the inclusion of parabens is nowadays poorly accepted by the consumers, imidazolidinyl urea was included as the antimicrobial component. Regarding pH evaluation, there were no significant alterations during the 90 days of observation, with values ranging between 5.5 and 6.5. The antioxidant activity of the prepared hydrogels was assessed and compared with a blank formulation (with all the components used in the hydrogel formulation, except the extract) and also with the results obtained for the extracts alone, at the same concentration (1 00 jlg/ml). The antioxidant activity measured in each hydrosoluble gel is very close to the value obtained for the isolated extract, in what regards inhibition of lipid peroxidation using thiobarbituric acid reactive substances (TBARS) and Beta carotene bleaching inhibition, 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity and reducing power. Hydrogels prepared with ethanolic extracts showed higher antioxidant activity than aqueous extracts, unless in Beta carotene bleaching inhibition assay. In general, it became evident that the inclusion of extracts in the prepared hydrosoluble gels caused very limited losses in their bioactivity.por
dc.identifier.citationBarreira, João C.M., Rodrigues, Sandra; Carvalho, Ana Maria; Ferreira, Isabel C.F.R. (2013). Development of paraben-free hydrogel based on plant extracts for topical application. In 1st Symposium on Medicinal Chemistry. Bragapor
dc.identifier.urihttp://hdl.handle.net/10198/8645
dc.language.isoengpor
dc.peerreviewedyespor
dc.relationStrategic Project - UI 690 - 2011-2012
dc.relationBIOACTIVE PROPERTIES & CYTOPROTECTIVE POTENTIAL OF NATURAL EXTRACTS/INDIVIDUAL COMPOUNDS: APPLICATION OF SINGLE CELL GEL ELECTROPHORESIS AND OTHER BIOCHEMICAL, CHEMICAL AND ELECTROCHEMICAL ASSAYS
dc.titleDevelopment of paraben-free hydrogel based on plant extracts for topical applicationpor
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 690 - 2011-2012
oaire.awardTitleBIOACTIVE PROPERTIES & CYTOPROTECTIVE POTENTIAL OF NATURAL EXTRACTS/INDIVIDUAL COMPOUNDS: APPLICATION OF SINGLE CELL GEL ELECTROPHORESIS AND OTHER BIOCHEMICAL, CHEMICAL AND ELECTROCHEMICAL ASSAYS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0690%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F72802%2F2010/PT
oaire.citation.conferencePlaceBraga, Portugalpor
oaire.citation.title1st Symposium on Medicinal Chemistry of University of Minho. 17 de Maio de 2013por
oaire.fundingStream6817 - DCRRNI ID
person.familyNameBarreira
person.familyNameRodrigues
person.familyNameCarvalho
person.familyNameFerreira
person.givenNameJoão C.M.
person.givenNameSandra
person.givenNameAna Maria
person.givenNameIsabel C.F.R.
person.identifierID G-7399-2011
person.identifier144781
person.identifier.ciencia-id651F-D964-32E1
person.identifier.ciencia-idD31A-35AF-E2A9
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0003-1233-0990
person.identifier.orcid0000-0003-3301-1729
person.identifier.orcid0000-0001-5508-5935
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridD-8269-2013
person.identifier.ridC-6486-2008
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id54895546900
person.identifier.scopus-author-id14048942500
person.identifier.scopus-author-id20336503900
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typeconferenceObjectpor
relation.isAuthorOfPublication4629b12c-39b0-4da8-8b8d-6efba5cf2d81
relation.isAuthorOfPublication684ab6a0-e3ea-4b6e-9874-d20d71e2a3f5
relation.isAuthorOfPublication977f5254-f7c5-4c91-873f-2700ecd4692f
relation.isAuthorOfPublicationbd0d1537-2e03-41fb-b27a-140af9c35db8
relation.isAuthorOfPublication.latestForDiscovery684ab6a0-e3ea-4b6e-9874-d20d71e2a3f5
relation.isProjectOfPublicationc59f09d4-9931-4f2e-babb-ef8bed998be7
relation.isProjectOfPublication3ff07254-7d34-46ec-a291-9228bc17eac4
relation.isProjectOfPublication.latestForDiscovery3ff07254-7d34-46ec-a291-9228bc17eac4

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Oral Nac. 34.pdf
Size:
663.47 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

CIMO - Resumos em Proceedings Não Indexados à WoS/Scopus