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Natural Mineral Water–Plant Extract Combinations as Potential Anti-Aging Ingredients: An In Vitro Evaluation

2025Artigo científico Acesso aberto
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datacite.subject.fosCiências Naturais::Ciências Biológicas
datacite.subject.fosEngenharia e Tecnologia::Engenharia Química
datacite.subject.fosCiências Naturais::Ciências Químicas
datacite.subject.sdg04:Educação de Qualidade
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorGomes, Carolina P.
dc.contributor.authorOliveira, Ana S.
dc.contributor.authorRolo, Joana
dc.contributor.authorSilveira, Tayse F. F. da
dc.contributor.authorPalmeira de Oliveira, Rita
dc.contributor.authorAlves, Maria José
dc.contributor.authorPlasencia, Paula
dc.contributor.authorPalmeira de Oliveira, Ana
dc.date.accessioned2025-11-17T13:39:54Z
dc.date.available2025-11-17T13:39:54Z
dc.date.issued2025
dc.description.abstractNatural mineral waters (NMWs) and plant extracts have long been valued for their therapeutic properties and skin benefits. This study investigated, in vitro, the role of five Portuguese NMWs (A-E), combined with plant extracts from five species (Ficus carica L., Rubus idaeus L., Vaccinium myrtillus, Cistus ladanifer and Thymus x citriodorus) as bioactive ingredients. Antioxidant capacity was assessed using the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) method. Cellular biocompatibility was evaluated in fibroblasts (L929) and macrophages (RAW 264.7). Skin-repairing and anti-senescence properties were evaluated in L929 cells through the scratch-wound method and beta-galactosidase assay. Superoxide dismutase (SOD) was quantified using a commercial kit, and lipopolysaccharide-induced reactive oxygen species (ROS) were quantified using a fluorescent probe (H2DCFDA) in RAW 264.7. The results highlighted the beneficial impact of extracts combined with NMWs. An increase in antioxidant capacity of up to 90% was observed in mixtures comprising Ficus carica L., compared with NMWs alone. In contrast, mixtures with Cistus ladanifer showed promising anti-aging potential, with a 40% decrease in senescent cells and a 33% ROS reduction. Rubus idaeus L. extract produced an increase in cell migration capacity (up to 50%), depending on the NMW. This study highlights the potential synergism of natural ingredients with plant extracts for anti-aging.eng
dc.description.sponsorshipThis work was supported by Projeto Aquae Vitae-Água Termal como Fonte de Vida e Saúde [PD20-00003], a Project funded under the Promove program of Fundação La Caixa, in partnership with BPI and FCT. This work was also developed within the scope of the CICSUBI projects [UIDB/00709/2020] and [UIDP/00709/2020], financed by national funds through the Portuguese Foundation for Science and Technology/MCTES (FCT). Promove program of Fundação La Caixa also provided financial support to ASO and CPG through research scholarships. This work was also supported by national funds through FCT/MCTES (PIDDAC): CIMO, UIDB/00690/2020 (https://doi.org/10.54499/UIDB/00690/2020 (accessed on 17 April 2025)) and UIDP/00690/2020 (https://doi.org/10.54499/UIDP/00690/2020 (accessed on 17 April 2025)); and SusTEC, LA/P/0007/2020 (https://doi.org/10.54499/LA/P/0007/2020 (accessed on 17 April 2025)).
dc.identifier.citationGomes, Carolina P.; Oliveira, Ana S.; Rolo, Joana; Silveira, Tayse F.F. da; Palmeira de Oliveira, Rita; Alves, Maria José; Plasencia, Paula; Palmeira de Oliveira, Ana (2025). Natural Mineral Water–Plant Extract Combinations as Potential Anti-Aging Ingredients: An In Vitro Evaluation. Cosmetics. ISSN 2079-9284. 12:3, p. 1-19
dc.identifier.doi10.3390/cosmetics12030113
dc.identifier.issn2079-9284
dc.identifier.urihttp://hdl.handle.net/10198/35084
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationHealth Sciences Research Centre
dc.relationHealth Sciences Research Centre
dc.relationMountain Research Center
dc.relationAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
dc.relation.ispartofCosmetics
dc.rights.urihttp://creativecommons.org/licenses/by-nd/4.0/
dc.subjectAnti-aging
dc.subjectAgro-industrial residues
dc.subjectHydrolates
dc.subjectNatural mineral waters
dc.subjectSkincare
dc.titleNatural Mineral Water–Plant Extract Combinations as Potential Anti-Aging Ingredients: An In Vitro Evaluationeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleMountain Research Center
oaire.awardTitleAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00709%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0007%2F2020/PT
oaire.citation.endPage19
oaire.citation.issue3
oaire.citation.startPage1
oaire.citation.titleCosmetics
oaire.citation.volume12
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameSilveira
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person.familyNamePlasencia
person.givenNameTayse F. F. da
person.givenNameMaria José
person.givenNamePaula
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person.identifier.orcid0000-0001-8506-4393
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person.identifier.ridM-6624-2016
person.identifier.scopus-author-id16400584800
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project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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