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Phytochemicals and bioactivity in wild German and Roman chamomiles infusions

2013Conference object Open access
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dc.contributor.authorGuimarães, Rafaela
dc.contributor.authorBarros, Lillian
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorCarvalho, Ana Maria
dc.contributor.authorQueiroz, Maria João R.P.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2013-09-10T08:53:53Z
dc.date.available2013-09-10T08:53:53Z
dc.date.issued2013
dc.description.abstractNatural matrices represent a rich source of biologically active compounds and are an example of molecular diversity, with recognized potential in drug discovery. In the present work, the infusions of Matricaria recutita L. (German chamomile) and Chamaemelum nobile L. (Roman chamomile) were submitted to an analysis of phenolic compounds and evaluation of bioactivity. Phenolic compounds were characterized by reversed-phase high performance liquid chromatography coupled to diode array detection and mass spectrometry with electron spray ionization (HPLCDAD/ ESI-MS). The bioactivity of the samples was tested in different human tumour cell lines (breast- MCF-7, lung- NCI-H460, colon- HCT -15, cervical- He l a and hepatocellular- HepG2 carcinomas}, and the hepatotoxicity was evaluated using a porcine liver primary cell culture (nontumour cells, PLP2) [1 ,2]. The major compounds found were luteolin 0-acylhexoside in German chamomile, and 5-0-caffeoylquinic acid and an apigenin derivative in Roman chamomile. The highest potential antioxidant activity was showed by German chamomile in all the in vitro assays. Both the infusions showed inhibitory activity of the growth of HCT -15 and He la cell lines, without hepatotoxicity (GI 50>400 μg/ml). Nevertheless, Roman chamomile infusion presented the highest inhibitory activity for all the cell lines (GI50<168 μg/ml ). Overall, infusions of both chamomiles contain important phytochemicals with bioactive properties to be explored in medicinal, food, and cosmetic industries.por
dc.description.sponsorshipFCT and FEDER-COMPETE/QREN/EU (strategic projects PEstOE/ AGR/UI0690/201 1 and PEst-C/QUI/UI0686/2011 to CIMO and CQ-UM research centres, respectively). R. Guimaraes, L. Barros and R.C. Calhelha (grants SFRH/BD/78307/2011 , SFRH/BPD/4609/2008 and SRFH/BPD/4609/2008, respectively) also thank FCT, POPH-QREN and FSE.por
dc.identifier.citationGuimarães, Rafaela; Barros, Lillian; Calhelha, Ricardo C.; Carvalho, Ana Maria; Queiroz, Maria-João R. P.; Ferreira, Isabel C.F.R. (2013). Phytochemicals and bioactivity in wild German and Roman chamomiles infusions. In 1st Symposium on Medicinal Chemistry. Bragapor
dc.identifier.urihttp://hdl.handle.net/10198/8695
dc.language.isoengpor
dc.peerreviewedyespor
dc.relationSFRH/BPD/4609/2008
dc.relationStrategic Project - UI 690 - 2011-2012
dc.relationStrategic Project - UI 686 - 2011-2012
dc.titlePhytochemicals and bioactivity in wild German and Roman chamomiles infusionspor
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 690 - 2011-2012
oaire.awardTitleStrategic Project - UI 686 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0690%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6820 - DCRRNI ID/PEst-C%2FQUI%2FUI0686%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F78307%2F2011/PT
oaire.citation.conferencePlaceBraga, Portugalpor
oaire.citation.title1st Symposium on Medicinal Chemistry of University of Minhopor
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6820 - DCRRNI ID
oaire.fundingStreamSFRH
person.familyNameBarros
person.familyNameCalhelha
person.familyNameCarvalho
person.familyNameFerreira
person.givenNameLillian
person.givenNameRicardo C.
person.givenNameAna Maria
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifierID G-7399-2011
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person.identifier.ciencia-id9616-35CB-D001
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person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0001-5508-5935
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-3600-2013
person.identifier.ridJ-2172-2014
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id20336503900
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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