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Wild mushrooms Clitocybe alexandri and Lepista inversa: In vitro antioxidant activity and growth inhibition of human tumour cell lines

2010Journal article Restricted access
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dc.contributor.authorVaz, Josiana A.
dc.contributor.authorHeleno, Sandrina A.
dc.contributor.authorMartins, Anabela
dc.contributor.authorAlmeida, Gabriela M.
dc.contributor.authorVasconcelos, M. Helena
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2011-01-06T16:54:03Z
dc.date.available2011-01-06T16:54:03Z
dc.date.issued2010
dc.description.abstractThe in vitro antioxidant and growth inhibitory activity of extracts obtained from two Portuguese wild mushrooms (Clitocybe alexandri and Lepista inversa) was studied in human tumour cell lines. The extracts were phenolic (methanolic and ethanolic) and polysaccharidic (boiling water). The antioxidant activity assays included evaluation of radical-scavenging capacity, reducing power and inhibition of lipid peroxidation measured in liposome solutions. Extract-induced cell growth inhibition was measured in four different tumour cell lines (lung, breast, colon and gastric cancer) using the SRB assay. The polysaccharidic extract oft. inversa was the most potent as antioxidant (EC50 < 1.8 +/- 0.1 mg/ml), while the phenolic ethanolic extract of C alexandri was the most potent as inhibitor of growth of the studied cancer cell lines (Gl(50) <26.0 +/- 1.3 mu g/ml). Together, these activities indicate that these mushrooms are promising sources of bioactive compounds. (C) 2010 Elsevier Ltd. All rights reserved.por
dc.identifier.citationVaz, Josiana A.; Heleno, Sandrina A.; Martins, Anabela; Almeida, Gabriela M.; Vasconcelos, M. Helena; Ferreira, Isabel C.F.R. (2010). Wild mushrooms Clitocybe alexandri and Lepista inversa: In vitro antioxidant activity and growth inhibition of human tumour cell lines. Food and Chemical Toxicology. ISSN 0278-6915. 48:10, p. 2881-2884por
dc.identifier.doi10.1016/j.fct.2010.07.021
dc.identifier.issn0278-6915
dc.identifier.urihttp://hdl.handle.net/10198/3037
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.relationPOTENCIAL NUTRACEUTICO DE COGUMELOS SILVESTRES DO NORDESTE DE PORTUGAL: ESTUDO DE PROPRIEDADES ANTIO-XIDANTES, ANTIPROLIFERATIVAS E INDUTORAS DA APOPTOSE
dc.subjectWild mushroomspor
dc.subjectAntioxidant activitypor
dc.subjectGrowth inhibitory activitypor
dc.titleWild mushrooms Clitocybe alexandri and Lepista inversa: In vitro antioxidant activity and growth inhibition of human tumour cell linespor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitlePOTENCIAL NUTRACEUTICO DE COGUMELOS SILVESTRES DO NORDESTE DE PORTUGAL: ESTUDO DE PROPRIEDADES ANTIO-XIDANTES, ANTIPROLIFERATIVAS E INDUTORAS DA APOPTOSE
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F43653%2F2008/PT
oaire.citation.endPage2884por
oaire.citation.issue48(10)por
oaire.citation.startPage2881por
oaire.citation.titleFood and Chemical Toxicologypor
person.familyNameVaz
person.familyNameHeleno
person.familyNameMartins
person.familyNameFerreira
person.givenNameJosiana A.
person.givenNameSandrina A.
person.givenNameAnabela
person.givenNameIsabel C.F.R.
person.identifier144781
person.identifier.ciencia-id171B-88BA-64F5
person.identifier.ciencia-id8B18-3095-6FC9
person.identifier.ciencia-id7B18-A810-6B93
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-6989-1169
person.identifier.orcid0000-0001-7224-1098
person.identifier.orcid0000-0001-6218-4413
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridL-5951-2014
person.identifier.ridG-5488-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id16305323200
person.identifier.scopus-author-id30067731800
person.identifier.scopus-author-id7203013518
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typearticlepor
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relation.isAuthorOfPublicatione89b5bf5-d315-49b6-871e-fa8eb6030676
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