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Bilirubin dependent on UGT1A1 polymorphisms, hemoglobin, fasting time and body mass index

2011Journal article Open access
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dc.contributor.authorRodrigues, Carina
dc.contributor.authorCosta, Elísio
dc.contributor.authorVieira, Emília
dc.contributor.authorCarvalho, João
dc.contributor.authorSantos, Rosário
dc.contributor.authorRocha-Pereira, Petronila
dc.contributor.authorSantos-Silva, Alice
dc.contributor.authorBronze-da-Rocha, Elsa
dc.date.accessioned2011-09-16T14:00:46Z
dc.date.available2011-09-16T14:00:46Z
dc.date.issued2011
dc.descriptionIn Presspor
dc.description.abstractIn humans, bilirubin levels are influenced by different factors. This study aims to evaluate the influence of several nongenetic factors (hematologic data, smoking status, alcohol intake, fasting time, physical activity, oral contraceptive therapy and caloric intake) and the genetic contribution of UGT1A1 polymorphisms for the bilirubin levels, in a cohort of young women. Hematologic data, bilirubin and screening of TA duplication in the TATA box region of the UGT1A1 gene were performed in 146 young white women. Body mass index (BMI) and body fat were determined, and a questionnaire about fasting time, smoking habits, oral contraceptive therapy, caloric intake and physical activity was performed. Participants were divided into 3 groups according to the tertiles of bilirubin levels. Subjects from the second and third tertile had significant increases in hemoglobin (Hb) concentration, hematocrit, mean cell Hb and mean cell Hb concentration compared with those in the first tertile. Red blood cell count was significantly increased in subjects in the third tertile. A significant increased frequency was found for the c.-41_-40dupTA allele in homozygosity for both second and third tertiles. Multiple linear regression analysis showed that the c.-41_-40dupTA allele, Hb, BMI and fasting hours were independent variables associated with bilirubin serum levels. Hb concentration, fasting time and BMI were identified as nongenetic causes, together with the genetic UGT1A1 polymorphisms, as the main factors associated with variations in bilirubin levels in a healthy female population.por
dc.description.sponsorshipBolsa de doutoramento SFRH/BD/42791/2007 da Fundação para a Ciência e Tecnologia (FCT) e Fundo Social Europeu.por
dc.identifier.citationRodrigues, Carina; Costa, Elísio; Vieira, Emília; Carvalho, João; Santos, Rosário; Rocha-Pereira, Petronila; Santos-Silva, Alice; Bronze-da-Rocha, Elsa; (2011). Bilirubin dependent on UGT1A1 polymorphisms,hemoglobin, fasting time and body mass índex. American Journal of the Medical Sciences. ISSN 0002-9629. 343:2, p. 114-118.por
dc.identifier.doi10.1097/MAJ.0b013e318223460f
dc.identifier.issn0002-9629
dc.identifier.otherdoi: 10.1097/MAJ.0b013e318223460f
dc.identifier.urihttp://hdl.handle.net/10198/6145
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherLippincott Williams & Wilkins,por
dc.subjectBilirubin levelspor
dc.subjectUGT1A1por
dc.subjectGenetic and nongenetic factors hemoglobinpor
dc.subjectGilbert’s syndromepor
dc.titleBilirubin dependent on UGT1A1 polymorphisms, hemoglobin, fasting time and body mass indexpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleAmerican Journal of Medical Sciencepor
person.familyNameRodrigues
person.givenNameCarina
person.identifier.ciencia-idC415-C677-0253
person.identifier.orcid0000-0001-9773-1413
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublicationef666665-6593-48be-bc48-6a1bb58bedbd
relation.isAuthorOfPublication.latestForDiscoveryef666665-6593-48be-bc48-6a1bb58bedbd

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