Repository logo
 
Publication

Phenolic bioactives as antiplatelet aggregation factors: the pivotal ingredients in maintaining cardiovascular health

2021Journal article Open access
Simple item page
dc.contributor.authorSharifi-Rad, Javad
dc.contributor.authorQuispe, Cristina
dc.contributor.authorZam, Wissam
dc.contributor.authorKumar, Manoj
dc.contributor.authorCardoso, Susana M.
dc.contributor.authorPereira, Olívia R.
dc.contributor.authorAdemiluyi, Adedayo O.
dc.contributor.authorAdeleke, Oluwakemi
dc.contributor.authorMoreira, Ana Catarina
dc.contributor.authorŽivković, Jelena
dc.contributor.authorNoriega, Felipe
dc.contributor.authorAyatollahi, Seyed Abdulmajid
dc.contributor.authorKobarfard, Farzad
dc.contributor.authorFaizi, Mehrdad
dc.contributor.authorMartorell, Miquel
dc.contributor.authorCruz-Martins, Natália
dc.contributor.authorButnariu, Monica
dc.contributor.authorBagiu, Iulia Cristina
dc.contributor.authorBagiu, Radu Vasile
dc.contributor.authorAlshehri, Mohammed M.
dc.contributor.authorCho, William C.
dc.date.accessioned2021-10-01T15:50:35Z
dc.date.available2021-10-01T15:50:35Z
dc.date.issued2021
dc.description.abstractCardiovascular diseases (CVD) are one of the main causes of mortality in the world. The development of these diseases has a specific factor—alteration in blood platelet activation. It has been shown that phenolic compounds have antiplatelet aggregation abilities and a positive impact in the management of CVD, exerting prominent antioxidant, anti-inflammatory, antitumor, cardioprotective, antihyperglycemic, and antimicrobial effects. Thus, this review is intended to address the antiplatelet activity of phenolic compounds with special emphasis in preventing CVD, along with the mechanisms of action through which they are able to prevent and treat CVD. In vitro and in vivo studies have shown beneficial effects of phenolic compound-rich plant extracts and isolated compounds against CVD, despite that the scientific literature available on the antiplatelet aggregation ability of phenolic compounds in vivo is scarce. Thus, despite the current advances, further studies are needed to confirm the cardioprotective potential of phenolic compounds towards their use alone or in combination with conventional drugs for effective therapeutic interventions.pt_PT
dc.description.sponsorshipN.C.-M. acknowledges the Portuguese Foundation for Science and Technology under the Horizon 2020 Program (PTDC/PSI-GER/28076/2017).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSharifi-Rad, Javad; Quispe, Cristina; Zam, Wissam; Kumar, Manoj; Cardoso, Susana M.; Pereira, Olivia R.; Ademiluyi, Adedayo O.; Adeleke, Oluwakemi; Moreira, Ana Catarina; Živković, Jelena; Noriega, Felipe; Ayatollahi, Seyed Abdulmajid; Kobarfard, Farzad; Faizi, Mehrdad; Martorell, Miquel; Cruz-Martins, Natália; Butnariu, Monica; Bagiu, Iulia Cristina; Bagiu, Radu Vasile; Alshehri, Mohammed M.; Cho, William C. (2021). Phenolic bioactives as antiplatelet aggregation factors: the pivotal ingredients in maintaining cardiovascular health. Oxidative Medicine and Cellular Longevity. ISSN 1942-0994. Special issue. p. 1-19pt_PT
dc.identifier.doi10.1155/2021/2195902pt_PT
dc.identifier.issn1942-0994
dc.identifier.urihttp://hdl.handle.net/10198/23956
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherHindawipt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPhenolic compoundspt_PT
dc.subjectAntiplateletpt_PT
dc.subjectCardiovascular healthpt_PT
dc.titlePhenolic bioactives as antiplatelet aggregation factors: the pivotal ingredients in maintaining cardiovascular healthpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FPSI-GER%2F28076%2F2017/PT
oaire.citation.conferencePlaceUnited Kingdompt_PT
oaire.citation.endPage19pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleOxidative Medicine and Cellular Longevitypt_PT
oaire.citation.volume2021pt_PT
oaire.fundingStream3599-PPCDT
person.familyNamePereira
person.givenNameOlívia R.
person.identifier145216
person.identifier.ciencia-idB312-AF21-D2FA
person.identifier.orcid0000-0002-6275-3134
person.identifier.ridH-1049-2014
person.identifier.scopus-author-id52264387000
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicatione8fdab9a-3ad6-47e6-b90c-7a37aabcb453
relation.isAuthorOfPublication.latestForDiscoverye8fdab9a-3ad6-47e6-b90c-7a37aabcb453
relation.isProjectOfPublicatione7a06432-01d3-4cfb-9b3a-3fcdc8985fc2
relation.isProjectOfPublication.latestForDiscoverye7a06432-01d3-4cfb-9b3a-3fcdc8985fc2

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Phenolic Bioactives as Antiplatelet Aggregation Factors_2021.pdf
Size:
1.63 MB
Format:
Adobe Portable Document Format
Download

Collections

CIMO - Artigos em Revistas Indexados à WoS/Scopus