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Molecular imprinting and surface grafting of glycoprotein fragments in polymeric nanosystems: from cancer diagnosis to virus targeting

2023Book part Restricted access
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dc.contributor.authorBzainia, Amir
dc.contributor.authorGomes, Catarina P.
dc.contributor.authorDias, Rolando
dc.contributor.authorCosta, Mário Rui
dc.date.accessioned2024-02-22T09:36:53Z
dc.date.available2024-02-22T09:36:53Z
dc.date.issued2023
dc.description.abstractGlycoproteins and glycans are widely found in eukaryotes, prokaryotes, archaea, and viruses. Many fundamental biological mechanisms, such as molecular recognition, signal transduction, cell adhesion, and immune response are regulated with the intervention of glycoproteins, glycans, and monosaccharides. Several diseases are a result of anomalous changes affecting the structure of these molecules or their abnormal expression. Therefore, glycoproteins, glycans, and monosaccharides are often considered biomarkers for diagnosis purposes and therapeutic agents in cancer treatment. The development of vaccines and antibodies for infection diseases also relies on these kinds of molecular structures. The mimic of glycoproteins or their molecular recognition with tailored synthetic polymers can be used to develop tools aiding in the diagnosis and treatment of different kinds of diseases, through sensing, imaging, controlled drug delivery, virus inhibition, and so on. This chapter describes the use of molecular imprinting techniques and grafting mechanisms with glycoproteins, glycans, and saccharides aiming at the development of such kinds of synthetic polymers. Due to their practical relevance, a special emphasis is given to systems involving sialic acid or derivatives, boronic acid-based polymers (e.g., with surface-oriented molecular imprinting of glycoproteins) and glycopolymers synthesis through grafting of saccharide moieties in polymer backbones or nano-surfaces (e.g., for the generation of macromolecules/surfaces with polyvalent interactions). Along the text, the use of “controlled” (or rather reversibly deactivated) radical polymerization is highlighted to show new opportunities arising in this field with these synthetic routes. Improved precision in the design of special molecular architectures, functionalization, hybridization, surface modification, and size control of macromolecular-based devices (e.g., nanofabrication) are some important goals in the development of tailored synthetic materials that can be achieved with controlled radical polymerization. Specific examples involving these special kinds of synthetic polymers with their application in cancer and virus targeting are provided.pt_PT
dc.description.sponsorshipAuthors acknowledge to Foundation for Science and Technology (FCT, Portugal) for financial support by national funds FCT/MCTES to CIMO (UIDB/00690/2020) and for the Base Funding—UIDB/50020/2020 of the Associate Laboratory LSRE-LCM—funded by national funds through FCT/MCTES (PIDDAC).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBzainia, Amir; Gomes, Catarina P.; Dias, Rolando; Costa, Mário Rui (2023). Molecular imprinting and surface grafting of glycoprotein fragments in polymeric nanosystems: from cancer diagnosis to virus targeting. In Polymeric Nanosystems: Theranostic Nanosystems. London: Elsevier. Vol. 1, p. 787-841. ISBN 978-0-3238-5656-0pt_PT
dc.identifier.doi10.1016/B978-0-323-85656-0.00012-7pt_PT
dc.identifier.isbn978-0-3238-5656-0
dc.identifier.urihttp://hdl.handle.net/10198/29581
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationMountain Research Center
dc.relationLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAntibodiespt_PT
dc.subjectBiomarkerspt_PT
dc.subjectControlled radical polymerizationpt_PT
dc.subjectGlycanspt_PT
dc.subjectGlycoproteinspt_PT
dc.subjectGraftingpt_PT
dc.subjectLiving polymerizationpt_PT
dc.subjectMolecular imprintingpt_PT
dc.subjectMonosaccharidespt_PT
dc.subjectNanoparticlespt_PT
dc.subjectPolymerizationpt_PT
dc.titleMolecular imprinting and surface grafting of glycoprotein fragments in polymeric nanosystems: from cancer diagnosis to virus targetingpt_PT
dc.typebook part
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardTitleLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50020%2F2020/PT
oaire.citation.endPage841pt_PT
oaire.citation.startPage787pt_PT
oaire.citation.titlePolymeric Nanosystems: Theranostic Nanosystemspt_PT
oaire.citation.volume1pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameBzainia
person.familyNameDias
person.givenNameAmir
person.givenNameRolando
person.identifier.ciencia-id6F16-0D30-3F93
person.identifier.ciencia-id8417-4D84-973B
person.identifier.orcid0000-0002-1835-1066
person.identifier.orcid0000-0001-7369-382X
person.identifier.ridM-8552-2013
person.identifier.scopus-author-id7102885104
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typebookPartpt_PT
relation.isAuthorOfPublication8a4c4b33-b838-40b1-91fd-592cd178da00
relation.isAuthorOfPublicationd7109687-6adf-4268-a462-8d1a2e2c01cb
relation.isAuthorOfPublication.latestForDiscovery8a4c4b33-b838-40b1-91fd-592cd178da00
relation.isProjectOfPublication29718e93-4989-42bb-bcbc-4daff3870b25
relation.isProjectOfPublication79ed495f-40dc-45d0-b98c-7e777db59e9b
relation.isProjectOfPublication.latestForDiscovery29718e93-4989-42bb-bcbc-4daff3870b25

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