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High hydrostatic pressure in the modulation of enzymatic and organocatalysis and life under pressure: a review

2023Journal article Open access
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dc.contributor.authorScepankova, Hana
dc.contributor.authorGalante, Diogo
dc.contributor.authorEspinoza-Suarez, Edelman
dc.contributor.authorPinto, Carlos A.
dc.contributor.authorEstevinho, Leticia M.
dc.contributor.authorSaraiva, Jorge A.
dc.date.accessioned2014-10-22T13:45:57Z
dc.date.available2014-10-22T13:45:57Z
dc.date.issued2023
dc.description.abstractThe interest in high hydrostatic pressure (HHP) is mostly focused on the inactivation of deleterious enzymes, considering the quality-related issues associated with enzymes in foods. However, more recently, HHP has been increasingly studied for several biotechnological applications, including the possibility of carrying out enzyme-catalyzed reactions under high pressure. This review aims to comprehensively present and discuss the effects of HHP on the kinetic catalytic action of enzymes and the equilibrium of the reaction when enzymatic reactions take place under pressure. Each enzyme can respond differently to high pressure, mainly depending on the pressure range and temperature applied. In some cases, the enzymatic reaction remains significantly active at high pressure and temperature, while at ambient pressure it is already inactivated or possesses minor activity. Furthermore, the effect of temperature and pressure on the enzymatic activity indicated a faster decrease in activity when elevated pressure is applied. For most cases, the product concentration at equilibrium under pressure increased; however, in some cases, hydrolysis was preferred over synthesis when pressure increased. The compiled evidence of the effect of high pressure on enzymatic activity indicates that pressure is an effective reaction parameter and that its application for enzyme catalysis is promising.por
dc.identifier.citationScepankova, Hana; Galante, Diogo; Espinoza-Suarez, Edelman; Pinto, Carlos A.; Estevinho, Leticia M.; Saraiva, Jorge A. (2023). High hydrostatic pressure in the modulation of enzymatic and organocatalysis and life under pressure: a review. Molecules. eISSN 1420-3049. 28:10, p. 1-17por
dc.identifier.doi10.3390/molecules28104172
dc.identifier.eissn1420-3049
dc.identifier.urihttp://hdl.handle.net/10198/10955
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherMDPIpor
dc.subjectEnzymepor
dc.subjectActivitypor
dc.subjectHigh hydrostatic pressurepor
dc.subjectEquilibriumpor
dc.subjectSubstratepor
dc.titleHigh hydrostatic pressure in the modulation of enzymatic and organocatalysis and life under pressure: a reviewpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleMoleculespor
person.familyNameEstevinho
person.givenNameLetícia M.
person.identifier.ciencia-idBA14-09D6-A406
person.identifier.orcid0000-0002-9249-1948
person.identifier.scopus-author-id6506577664
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication4a1d5ba2-1854-4ca5-89a4-73f35e964df9
relation.isAuthorOfPublication.latestForDiscovery4a1d5ba2-1854-4ca5-89a4-73f35e964df9

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