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Cell-free layer analysis in a polydimethysiloxane microchannel: A global approach

2016Journal article Open access
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dc.contributor.authorPinto, Elmano
dc.contributor.authorFaustino, Vera
dc.contributor.authorPinho, Diana
dc.contributor.authorRodrigues, Raquel Oliveira
dc.contributor.authorLima, Rui A.
dc.contributor.authorPereira, Ana I.
dc.date.accessioned2018-01-31T10:00:00Z
dc.date.accessioned2018-01-31T15:40:40Z
dc.date.available2018-01-31T10:00:00Z
dc.date.available2018-01-31T15:40:40Z
dc.date.issued2016
dc.description.abstractThe cell-free layer (CFL) is a hemodynamic phenomenon that has an important contribution to the rheological properti es of blood flowing in microvessels. The present work aims to find the closest function describing RBCs flowing around the cell depleted layer in a polydimethysiloxane (PDMS) microchannel with a diverging and a converging bifurcation. The flow behaviour of the CFL was investigated by using a high-speed video microscopy system where special attention was devoted to its behaviour before the bifurcation and after the confluence of the microchannel. The numerical data was first obtained by using a manual tracking plugin and then analysed using the genetic algorithm approach. The results show that for the majority of the cases the function that more closely resembles the CFL boundary is the sum of trigonometric functions.en_EN
dc.description.sponsorshipThe authors acknowledge the financial support provided by PTDC/SAU-ENB/116929/ 2010 and EXPL/EMS-SIS/2215/2013 from FCT (Science and Technology Foundation), COMPETE, QREN and European Union (FEDER). R.O. Rodrigues, D. Pinho and V. Faustino acknowledge respectively, the PhD scholarships SFRH/BD/97658/2013, SFRH/BD/89077/2012 and SFRH/BD/99696/2014 granted by FCT.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationPinto, Elmano; Faustino, Vera; Pinho, Diana; Rodrigues, Raquel Oliveira; Lima, R.; Pereira, Ana I. (2016). Cell-free layer analysis in a polydimethysiloxane microchannel: A global approach. International Journal of Medical Engineering and Informatics. ISSN 1755-0653. 8, p. 196-209en_EN
dc.identifier.doi10.1504/IJMEI.2016.077437en_EN
dc.identifier.issn1755-0653
dc.identifier.urihttp://hdl.handle.net/10198/15371
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationBIOMIMETIC - A biomimetic microdevice for the diagnosis of erythrocytes diseases based on their deformability
dc.relationMAGNETIC CARBON NANOSTRUCTURES AND STUDY OF THEIR TRANSPORT IN MICROFLUIDIC DEVICES FOR HYPERTHERMIA
dc.relationMicrofluidic system for cell separation and deformation assessment based on biomimetic and acoustofluidic methods
dc.subjectCell-free layeren_EN
dc.subjectCFLen_EN
dc.subjectGlobal optimisationen_EN
dc.subjectNonlinear optimisationen_EN
dc.subjectRBCSen_EN
dc.subjectRed blood cellsen_EN
dc.titleCell-free layer analysis in a polydimethysiloxane microchannel: A global approachen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleBIOMIMETIC - A biomimetic microdevice for the diagnosis of erythrocytes diseases based on their deformability
oaire.awardTitleMAGNETIC CARBON NANOSTRUCTURES AND STUDY OF THEIR TRANSPORT IN MICROFLUIDIC DEVICES FOR HYPERTHERMIA
oaire.awardTitleMicrofluidic system for cell separation and deformation assessment based on biomimetic and acoustofluidic methods
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FSAU-ENB%2F116929%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/EXPL%2FEMS-SIS%2F2215%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F97658%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F89077%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBD%2F99696%2F2014/PT
oaire.fundingStream5876-PPCDTI
oaire.fundingStreamCOMPETE
oaire.fundingStreamSFRH
oaire.fundingStreamFARH
person.familyNamePinho
person.familyNameLima
person.familyNamePereira
person.givenNameDiana
person.givenNameRui A.
person.givenNameAna I.
person.identifier.ciencia-id5214-ED0C-35E8
person.identifier.ciencia-idEE12-C3FB-349D
person.identifier.ciencia-id0716-B7C2-93E4
person.identifier.orcid0000-0002-3884-6496
person.identifier.orcid0000-0003-3428-637X
person.identifier.orcid0000-0003-3803-2043
person.identifier.ridH-5157-2016
person.identifier.ridF-3168-2010
person.identifier.scopus-author-id18437397800
person.identifier.scopus-author-id15071961600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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