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Advisor(s)
Abstract(s)
Sterols are amphipathic lipids that play essential roles in the physiology
of eukaryotic organisms in general. The fungal sterols are collectively known as
mycosterols and they exert numerous physiological functions. For humans, the
interest on this class of compounds relies heavily on the fact that they can promote
health benefits. For this reason, fungal extracts rich in sterols of various forms are
valuable and promising ingredients. One of the best-known benefits of mycosterols
is their inhibitory actions on cholesterol absorption and biosynthesis, but there are
several interesting regulatory and modulatory phenomena that mycosterols can
affect and that might eventually be of therapeutic interest. Within this domain, the
practical application of mycosterols or mycosterol-enriched fungal extracts presents
several challenges. The latter include isolation of novel bioactive mycosterols from
still underexploited fungi species, the optimization of existing methodologies for
production and recovery, extensive study of their applications and, finally, substantial
clinical trials for attesting their health benefits and safety.
Description
Keywords
Ergosterol Ergosterol derivatives Mushrooms Mycosterols
Pedagogical Context
Citation
Uber, Thaís Marques; Backes, Emanueli; Corrêa, Rúbia C.G.; Corrêa, Vanesa Gesser; Bracht, Adelar; Peralta, Rosane M. (2023). Mycosterols. Natural Secondary Metabolites: From Nature, Through Science, to Industry. Cham: Springer Nature. p. 673-686. ISBN 978-3-031-18586-1
Publisher
Springer Nature