Publicação
1-aryl-3-(4-(7-methylthieno[3,2-d]pyrimidin-4-yloxy)phenyl)ureas: synthesis and molecular modelling studies using VEGFR-2
| dc.contributor.author | Soares, Pedro | |
| dc.contributor.author | Froufe, Hugo J.C. | |
| dc.contributor.author | Abreu, Rui M.V. | |
| dc.contributor.author | Ferreira, Isabel C.F.R. | |
| dc.contributor.author | Borges, Fernanda | |
| dc.contributor.author | Queiroz, Maria João R.P. | |
| dc.date.accessioned | 2011-08-31T10:11:43Z | |
| dc.date.available | 2011-08-31T10:11:43Z | |
| dc.date.issued | 2011 | |
| dc.description.abstract | The development of anticancer drugs inhibiting angiogenesis has been an area of extensive research in the past decade. Angiogenesis is a requirement for tumor growth and metastasis and occurs through several signalling pathways. One key pathway that initiates proliferation and migration of endothelial cells is signalling through the vascular endothelial growth factor receptor-2 (VEGFR-2).1 Therefore, small molecules that block this signalling pathway through inhibition of VEGFR-2 tyrosine kinase activity could potentially inhibit angiogenesis and tumor growth. Recently works describing thienopyrimidine2 and thienopyrimidine 1,3-diarylureas3 as VEGFR-2 inhibitors have emerged in the literature. Here we present the synthesis of new 1-aryl-3-(4-(7-methylthieno[3,2-d]pyrimidin-4-yloxy)phenyl)ureas 2 in high yields by reaction of 4-[(7-methylthieno[3,2-d]pyridin-4-yl)oxy]aniline 1 with arylisocyanates. The former was prepared by regioselective nucleophilic substitution of 4-chloro-7-methylthieno[3,2-d]pyrimidine with 4-aminophenol | por |
| dc.identifier.citation | Soares, Pedro; Froufe, Hugo; Abreu, Rui M.V.; Ferreira, Isabel C.F.R.; Borges, Fernanda; Queiroz, Maria-João R.P. (2011). 1-Aryl-3-(4-(7-methylthieno[3,2-d]pyrimidin-4-yloxy)phenyl)ureas: synthesis and molecular modelling studies using VEGFR-2. In 2nd Iberic Meeting on Medicinal Chemistry: G Protein-Coupled Receptors and Enzymes in Drug Discovery. Porto | por |
| dc.identifier.uri | http://hdl.handle.net/10198/6079 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.relation | New antitumor and antiangiogenic heterocyclic compounds: synthesis, molecular modeling, screening of enzymatic inhibition and studies in tumor and endothelial cell lines with tyrosine kinase membrane receptors as targets | |
| dc.title | 1-aryl-3-(4-(7-methylthieno[3,2-d]pyrimidin-4-yloxy)phenyl)ureas: synthesis and molecular modelling studies using VEGFR-2 | por |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.awardNumber | PTDC/QUI-QUI/111060/2009 | |
| oaire.awardTitle | New antitumor and antiangiogenic heterocyclic compounds: synthesis, molecular modeling, screening of enzymatic inhibition and studies in tumor and endothelial cell lines with tyrosine kinase membrane receptors as targets | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FQUI-QUI%2F111060%2F2009/PT | |
| oaire.citation.conferencePlace | Porto, Portugal | por |
| oaire.citation.title | 2nd Iberic Meeting on Medicinal Chemistry: G Protein-Coupled Receptors and Enzymes in Drug Discovery, 12 a 15 de Junho de 2011 | por |
| oaire.fundingStream | 5876-PPCDTI | |
| person.familyName | Abreu | |
| person.familyName | Ferreira | |
| person.givenName | Rui M.V. | |
| person.givenName | Isabel C.F.R. | |
| person.identifier | 144781 | |
| person.identifier.ciencia-id | 0F19-0DE2-12A2 | |
| person.identifier.ciencia-id | 9418-CF95-9919 | |
| person.identifier.orcid | 0000-0002-7745-8015 | |
| person.identifier.orcid | 0000-0003-4910-4882 | |
| person.identifier.rid | E-8500-2013 | |
| person.identifier.scopus-author-id | 7003290613 | |
| person.identifier.scopus-author-id | 36868826600 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | openAccess | por |
| rcaap.type | conferenceObject | por |
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