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Phenolic Compounds from Pyrus communis Residues: Mechanisms of Antibacterial Action and Therapeutic Applications

2025Artigo científico Acesso aberto
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datacite.subject.fosCiências Agrárias::Agricultura, Silvicultura e Pescas
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorRibeiro, Jessica
dc.contributor.authorSilva, Vanessa
dc.contributor.authorIgrejas, Gilberto
dc.contributor.authorBarros, Lillian
dc.contributor.authorHeleno, Sandrina A.
dc.contributor.authorReis, Filipa S.
dc.contributor.authorPoeta, Patrícia
dc.date.accessioned2025-04-07T14:30:55Z
dc.date.available2025-04-07T14:30:55Z
dc.date.issued2025
dc.description.abstractThe food industry produces substantial amounts of fruit byproducts, which are often discarded despite their high content of bioactive compounds with potential therapeutic applications. Pyrus communis (pear) residues, which are particularly rich in phenolic compounds, represent a valuable yet underutilized resource. These byproducts have demonstrated significant antioxidant and antibacterial properties, suggesting their potential for medical and pharmaceutical applications. This review aims to provide a comprehensive analysis of the phenolic profile of P. communis byproducts, emphasizing their antioxidant and antibacterial mechanisms and their prospective use in combating oxidative stress and antibacterial resistance. Methods: A comprehensive review of the key phenolic compounds from P. communis residues was conducted using ScienceDirect and Google Scholar databases (from 2014 to 2024). Studies assessing antioxidant and antibacterial activities were reviewed, with a focus on their mechanisms of action against Gram-positive and Gram-negative bacterial pathogens. Results: A minimum of 14 distinct phenolic compounds were identified among P. communis residues. However, chlorogenic acid and catechin were identified as the primary contributors to the antioxidant activity of P. communis residues. Hydroquinone and chlorogenic acid exhibited strong antibacterial effects through membrane disruption, enzyme inhibition, and metabolic interference. Despite this potential, hydroquinone’s cytotoxicity and regulatory concerns limit its direct pharmaceutical application. Conclusions: While P. communis phenolics show promise as natural antibacterial agents, future research should address bioavailability, extraction standardization, and safe formulation strategies. Investigating their synergy with conventional antibiotics and improving stability for cosmetic applications are key steps toward their practical use. In vivo and clinical studies are crucial to validating their therapeutic potential and ensuring regulatory approval.eng
dc.description.sponsorshipThis work was supported by projects UI/00772 and LA/P/0059/2020 and funded by the Portuguese Foundation for Science and Technology (FCT). This work was financially supported by national funds through FCT/MCTES (PIDDAC): CIMO, UIDB/00690/2020 (DOI: 10.54499/UIDB/00690/2020) and UIDP/00690/2020 (DOI: 10.54499/UIDP/00690/2020); and SusTEC, LA/P/0007/2020 (DOI: 10.54499/LA/P/0007/2020). Jessica Ribeiro acknowledges the financial support provided by FCT through her PhD grant (2023.00592.BD). The authors acknowledge the national funding provided by FCT through the institutional scientific employment program contract with L. Barros and S. A. Heleno, as well as the individual scientific employment program contract with F.S. Reis (2021.03728.CEECIND).
dc.identifier.citationRibeiro, Jessica; Silva, Vanessa; Igrejas, Gilberto; Barros, Lillian; Heleno, Sandrina A.; Reis, Filipa S.; Poeta, Patrícia (2025). Phenolic Compounds from Pyrus communis Residues: Mechanisms of Antibacterial Action and Therapeutic Applications. Antibiotics. ISSN 2079-6382. 14:3, p. 1-24
dc.identifier.doi10.3390/antibiotics14030280
dc.identifier.issn2079-6382
dc.identifier.urihttp://hdl.handle.net/10198/34400
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationAssociate Laboratory for Animal and Veterinary Sciences
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.relationAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
dc.relationCYPonins: Cypress saponins as a possible bio-based alternative to address high-mortality rate tumours
dc.relation.ispartofAntibiotics
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAntioxidant properties
dc.subjectChlorogenic acid
dc.subjectHydroquinone
dc.subjectBacterial resistance
dc.subjectNatural therapeutics
dc.subjectOxidative stress
dc.subjectPlant-derived compounds
dc.subjectSecondary metabolites
dc.titlePhenolic Compounds from Pyrus communis Residues: Mechanisms of Antibacterial Action and Therapeutic Applicationseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberLA/P/0059/2020
oaire.awardNumberUIDB/00690/2020
oaire.awardNumberUIDP/00690/2020
oaire.awardNumberLA/P/0007/2020
oaire.awardNumber2021.03728.CEECIND/CP1677/CT0001
oaire.awardTitleAssociate Laboratory for Animal and Veterinary Sciences
oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardTitleAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
oaire.awardTitleCYPonins: Cypress saponins as a possible bio-based alternative to address high-mortality rate tumours
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0059%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0007%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND4ed/2021.03728.CEECIND%2FCP1677%2FCT0001/PT
oaire.citation.endPage24
oaire.citation.issue3
oaire.citation.startPage1
oaire.citation.titleAntibiotics
oaire.citation.volume14
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamCEEC IND4ed
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameRibeiro
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person.givenNameJessica
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person.givenNameSandrina A.
person.givenNameFilipa S.
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project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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