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Chemical characterization and bioactive properties of Geranium molle L.: from the plant to the most active extract and its phytochemicals

2016Journal article Open access
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dc.contributor.authorGraça, Vânia C.
dc.contributor.authorBarros, Lillian
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorDias, Maria Inês
dc.contributor.authorCarvalho, Ana Maria
dc.contributor.authorSantos-Buelga, Celestino
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorSantos, Paulo F.
dc.date.accessioned2016-11-30T15:36:38Z
dc.date.available2016-11-30T15:36:38Z
dc.date.issued2016
dc.description.abstractAfter a period of indifference, in which synthetic compounds were favored, there is an increasing interest in the study of the biological properties of plants and the active principles responsible for their therapeutic properties. Geranium molle L. has been used in the Portuguese folk medicine for the treatment of various ailments including cancer but, unlike many of the species from the Geranium genus, its phytochemical characterization and biological activity are virtually unexplored. In this study a G. molle sample from Trás-os-Montes, north-eastern Portugal, was chemically characterized regarding nutritional value, free sugars, organic acids, fatty acids and tocopherols, and several aqueous (decoction, infusion) and organic (n-hexane, dichloromethane, ethyl acetate, acetone, methanol) extracts of the plant were assessed for their bioactive properties. The antioxidant activity was evaluated by means of the free radicals scavenging activity, reducing power and inhibition of lipid peroxidation. The cytotoxicity of the different extracts was assessed in vitro against several human cancer cell lines (breast, lung, cervical and hepatocellular carcinomas) and, additionally, their hepatotoxicity was evaluated using a porcine liver primary cell culture. G. molle was shown to be rich in carbohydrates and proteins, providing tocopherols and essential fatty acids. Amongst the various extracts, the acetone extract was found to have the highest content of phenolic compounds (mainly ellagitannins, but also some flavone and flavonol glycosides) as well as the highest antioxidant and cytotoxic activities. To the best of our knowledge, this is the first report on the chemical composition and bioactive properties of G. molle.pt_PT
dc.description.sponsorshipThis work is supported by national funds by FCT - Portuguese Foundation for Science and Technology, under the project UID/AGR/04033/2013 and PEst-OE/AGR/UI0690/2014. V.C. Graça, M.I. Dias, R.C. Calhelha and L. Barros thank FCT for SFRH/BD/52542/2014, SFRH/BD/84485/2012, SFRH/BPD/68344/2010 and SFRH/BPD/107855/2015 grants, respectively.pt_PT
dc.identifier.citationGraça, Vânia C.; Barros, Lillian; Calhelha, Ricardo C.; Dias, Maria Inês; Carvalho, Ana Maria; Santos-Buelga, Celestino; Ferreira, Isabel C.F.R.; Santos, Paulo F. (2016). Chemical characterization and bioactive properties of Geranium molle L.: from the plant to the most active extract and its phytochemicals. Food & Function. ISSN 2042-6496. 7:5, p. 2204-2212pt_PT
dc.identifier.doi10.1039/c5fo01479dpt_PT
dc.identifier.issn2042-6496
dc.identifier.urihttp://hdl.handle.net/10198/13569
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherRoyal Society of Chemistrypt_PT
dc.relationSFRH/BD/52542/2014pt_PT
dc.relationIMPROVING SECONDARY METABOLITES PRODUCTION THROUGH IN VITRO CULTURE TECHNIQUE: CHEMICAL AND GENETIC CHARACTERIZATION OF EDIBLE PLANTS, BIOACTIVE PROPERTIES AND MICROENCAPSULATION OF PHENOLIC FRACTIONS
dc.relationProviding industry and consumers with new alternative sources of natural additives from plant origin in the classes of preservatives and colouring agents: extraction, purification, stabilization and product development
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleChemical characterization and bioactive properties of Geranium molle L.: from the plant to the most active extract and its phytochemicalspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleIMPROVING SECONDARY METABOLITES PRODUCTION THROUGH IN VITRO CULTURE TECHNIQUE: CHEMICAL AND GENETIC CHARACTERIZATION OF EDIBLE PLANTS, BIOACTIVE PROPERTIES AND MICROENCAPSULATION OF PHENOLIC FRACTIONS
oaire.awardTitleProviding industry and consumers with new alternative sources of natural additives from plant origin in the classes of preservatives and colouring agents: extraction, purification, stabilization and product development
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAGR%2F04033%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/PEst-OE%2FAGR%2FUI0690%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F84485%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F68344%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F107855%2F2015/PT
oaire.citation.endPage2212pt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage2204pt_PT
oaire.citation.titleFood & Functionpt_PT
oaire.citation.volume7pt_PT
oaire.fundingStream5876
oaire.fundingStream5876
oaire.fundingStreamSFRH
person.familyNameBarros
person.familyNameCalhelha
person.familyNameDias
person.familyNameCarvalho
person.familyNameFerreira
person.givenNameLillian
person.givenNameRicardo C.
person.givenNameMaria Inês
person.givenNameAna Maria
person.givenNameIsabel C.F.R.
person.identifier469085
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person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0001-8744-7814
person.identifier.orcid0000-0001-5508-5935
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-3600-2013
person.identifier.ridJ-2172-2014
person.identifier.ridM-8242-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id35236343600
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person.identifier.scopus-author-id54388787000
person.identifier.scopus-author-id20336503900
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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