Repository logo
 
Publication

Multifunctional graphene-based magnetic nanocarriers for combined hyperthermia and dual stimuli-responsive drug delivery

2018Journal article Open access
Simple item page
dc.contributor.authorRodrigues, Raquel Oliveira
dc.contributor.authorBaldi, Giovanni
dc.contributor.authorDoumett, Saer
dc.contributor.authorGarcia-Hevia, Lorena
dc.contributor.authorGallo, Juan
dc.contributor.authorBañobre-López, Manuel
dc.contributor.authorDražić, Goran
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorLima, Rui A.
dc.contributor.authorGomes, Helder
dc.contributor.authorSilva, Adrián
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2019-02-04T17:00:41Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2019-02-04T17:00:41Z
dc.date.issued2018
dc.description.abstractThe synthesis of hydrophilic graphene-based yolk-shell magnetic nanoparticles functionalized with copolymer pluronic F-127 (GYSMNP@PF127) is herein reported to achieve an efficient multifunctional biomedical system for mild hyperthermia and stimuli-responsive drug delivery. In vitro tests revealed the extraordinary ability of GYSMNP@PF127 to act as smart stimuli-responsive multifunctional nanomedicine platform for cancer therapy, exhibiting (i) an outstanding loading capacity of91% (w/w,representing 910μgmg−1) of the chemotherapeutic drug doxorubicin, (ii) a high heating efficiency under an alternating (AC) magnetic field (intrinsic power loss ranging from 2.1–2.7nHm2kg−1), and (iii) a dual pH and thermal stimuli-responsive drug controlled release (46% at acidic tumour pH vs 7% at physiological pH) under AC magnetic field, in just 30min. Additionally, GYSMNP@PF127 presents optimal hydrodynamic diameter (DH=180nm) with negative surface charge, high haemocompatibility for blood stream applications and tumour cellular uptake of drug nanocarriers. Due to its physicochemical, magnetic and biocompatibility properties, the developed graphene-based magnetic nanocarrier shows high promise as dual exogenous (AC field)/endogenous (pH) stimuli-responsive actuators for targeted thermo-chemotherapy, combining magnetic hyperthermia and controlled drug release triggered by the abnormal tumour environment. The presented strategy and findings can represent a new way to design and develop highly stable added-value graphene-based nanostructures for the combined treatment of cancer.en_EN
dc.description.sponsorshipThis work was financially supported by: Project POCI-01-0145- FEDER-006984 – Associate Laboratory LSRE-LCM funded by FEDER through COMPETE2020 - Programa Operacional Competitividade e Internacionalização (POCI) – and by national funds through FCT - Fundação para a Ciência e a Tecnologia, and by project NORTE-01- 0145-FEDER-029394, RTChip4Theranostics, supported by Programa Operacional Regional do Norte - Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) and by Fundação para a Ciência e Tecnologia (FCT), IP. R.O.R. acknowledges the Ph.D. scholarship SFRH/BD/97658/2013 granted by FCT. A.M.T.S acknowledges the FCT Investigator 2013 Programme (IF/ 01501/2013), with financing from the European Social Fund and the Human Potential Operational Programme. G.D. acknowledges financing by Slovene Research Agency (J2-6754). M. B. acknowledges financial funding from POCTEP (Co-operational Programme for Crossborder Cooperation Spain-Portugal). This article is based upon work from COST Action RADIOMAG (TD1402), supported by COST (European Cooperation in Science and Technology).
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationRodrigues, Raquel Oliveira; Baldi, Giovanni; Doumett, Saer; Garcia-Hevia, Lorena; Gallo, Juan; Bañobre-López, Manuel; Dražić, Goran; Calhelha, Ricardo C.; Ferreira, Isabel C.F.R.; Lima, Rui; Gomes, Helder T.; Silva, Adrián (2018). Multifunctional graphene-based magnetic nanocarriers for combined hyperthermia and dual stimuli-responsive drug delivery. Materials Science and Engineering C. ISSN 0928-4931. 93, p. 206-217en_EN
dc.identifier.doi10.1016/j.msec.2018.07.060en_EN
dc.identifier.issn0928-4931
dc.identifier.urihttp://hdl.handle.net/10198/18658
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationMAGNETIC CARBON NANOSTRUCTURES AND STUDY OF THEIR TRANSPORT IN MICROFLUIDIC DEVICES FOR HYPERTHERMIA
dc.subjectCancer therapyen_EN
dc.subjectControlled-drug releaseen_EN
dc.subjectDoxorubicinen_EN
dc.subjectGraphene magnetic nanoparticlesen_EN
dc.subjectMagnetic hyperthermiaen_EN
dc.titleMultifunctional graphene-based magnetic nanocarriers for combined hyperthermia and dual stimuli-responsive drug deliveryen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMAGNETIC CARBON NANOSTRUCTURES AND STUDY OF THEIR TRANSPORT IN MICROFLUIDIC DEVICES FOR HYPERTHERMIA
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F97658%2F2013/PT
person.familyNameCalhelha
person.familyNameFerreira
person.familyNameGomes
person.givenNameRicardo C.
person.givenNameIsabel C.F.R.
person.givenNameHelder
person.identifier144781
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-id9418-CF95-9919
person.identifier.ciencia-id6218-1E19-13EE
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0003-4910-4882
person.identifier.orcid0000-0001-6898-2408
person.identifier.ridJ-2172-2014
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
relation.isAuthorOfPublication2d5d1a41-7561-4a01-871c-b4c97da35053
relation.isAuthorOfPublicationbd0d1537-2e03-41fb-b27a-140af9c35db8
relation.isAuthorOfPublication0eb96337-224a-4339-9918-334436fbbb99
relation.isAuthorOfPublication.latestForDiscoverybd0d1537-2e03-41fb-b27a-140af9c35db8
relation.isProjectOfPublication95f49ee8-5b1f-45de-b818-d9334a4d8d0e
relation.isProjectOfPublication.latestForDiscovery95f49ee8-5b1f-45de-b818-d9334a4d8d0e

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
53.pdf
Size:
2.43 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.75 KB
Format:
Plain Text
Description:
Download

Collections

CIMO - Artigos em Revistas Indexados à WoS/Scopus