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Chemical composition, antimicrobial, antioxidant and cytotoxic activity of Rosa centifolia L. essential oil

2013Conference object Open access
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dc.contributor.authorNikolić, Miloš
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorFernandes, Ângela
dc.contributor.authorMarković, Dejan
dc.contributor.authorMarković, Tatjana
dc.contributor.authorĆirić, Ana
dc.contributor.authorGlamočlija, Jasmina
dc.contributor.authorSoković, Marina
dc.date.accessioned2014-03-27T17:02:29Z
dc.date.available2014-03-27T17:02:29Z
dc.date.issued2013
dc.description.abstractThe genus Rosa comprises more than 200 species appreciated for their use in perfume and cosmetic industry. The aim of this study was to investigate chemical composition, antimicrobial, antioxidant and cytotoxic activities of Rosa centifolia L. essential oil, in an attempt to contribute to the use of this plant as alternative product for microbial control and cancer therapy. The results of GC/MS analysis showed the presence of 12 components. The major constituents were: phenyl ethyl alcohol (57 .71%), citronellol (21.61%), geraniol (12.09%). The rose oil showed strong antimicrobial activity inhibiting the growth of selected oral microorganisms (MIC 0.13-0.25 and MBC 0.25-0.50; MIC 0.03-0.13 and MFC 0.06-0.25 mg/ml), assessed by the microdilution method. The results of OPPH activity (2.10 mg/ml), reducing power (0.66 mg/ml), β-carotene bleaching inhibition (0.43 mg/ml) and thiobarbituric acid reactive substances (TSARS} assay (0.11 mg/ml) indicate good antioxidant potential. Cytotoxic activity was tested against human tumor cell lines (breast, lung, colon, cervical and hepatocellular carcinomas} and in a non-tumour liver primary culture (PLP2). R. centifolia oil was found to be very active against tumour cell lines with Gl ranging from 49.55-90.94 μg/ml. Oil showed no hepatotoxicity in PLP2 cell line (GI v- 400 5~g/ml). Overall, R. centifolia contains important phytochemicals with bioactive properties (mainly antitumour potential) to be explored in the pharmaceutical and for medicinal purposes.por
dc.description.sponsorshipSerbian Ministry of Education and Science for financial support (173032) and to FG (Portugal) for CIMO strategic project PEstOE/AGR/UI0690/2011, SFRH/BP0/68344/2010 (R.C. Calhelha) and SFRH/B0/76019/2011 (A. Fernandes) grants.por
dc.identifier.citationNikolić, Milos; Ferreira, Isabel C.F.R.; Calhelha, Ricardo C.; Fernandes, Ângela; Marković, Dejan; Marković, Tatjana; Ćirić, Ana; Glamočlija, Jasmina; Soković, Marina (2013). Chemical composition, antimicrobial, antioxidant and cytotoxic activity of Rosa centifolia L. essential oil. In International conference on natural products utilization: From plants to Pharmacy Shelf. Bansko, Bulgáriapor
dc.identifier.urihttp://hdl.handle.net/10198/9398
dc.language.isoengpor
dc.peerreviewedyespor
dc.relationStrategic Project - UI 690 - 2011-2012
dc.titleChemical composition, antimicrobial, antioxidant and cytotoxic activity of Rosa centifolia L. essential oilpor
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 690 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0690%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F68344%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F76019%2F2011/PT
oaire.citation.conferencePlaceBansko, Bulgariapor
oaire.citation.titleInternational conference on natural products utilization: From plants to Pharmacy Shelfpor
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamSFRH
oaire.fundingStreamSFRH
person.familyNameFerreira
person.familyNameCalhelha
person.familyNameFernandes
person.givenNameIsabel C.F.R.
person.givenNameRicardo C.
person.givenNameÂngela
person.identifier144781
person.identifier.ciencia-id9418-CF95-9919
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-id2015-0434-AE7C
person.identifier.orcid0000-0003-4910-4882
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0002-0157-9873
person.identifier.ridE-8500-2013
person.identifier.ridJ-2172-2014
person.identifier.scopus-author-id36868826600
person.identifier.scopus-author-id6507978333
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typeconferenceObjectpor
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