Repository logo
 
Publication

Thymus species from romanian spontaneous flora as promising source of phenolic secondary metabolites with health-related benefits

2023Journal article Open access
Simple item page
dc.contributor.authorBabotă, Mihai
dc.contributor.authorFrumuzachi, Oleg
dc.contributor.authorMafra, Isabel
dc.contributor.authorNicolescu, Alexandru
dc.contributor.authorDias, Maria Inês
dc.contributor.authorPinela, José
dc.contributor.authorBarros, Lillian
dc.contributor.authorAñibarro-Ortega, Mikel
dc.contributor.authorStojković, Dejan
dc.contributor.authorCarevic, Tamara
dc.contributor.authorMocan, Andrei
dc.contributor.authorLopez, Victor
dc.contributor.authorCrisan, Gianina
dc.date.accessioned2014-08-11T15:23:14Z
dc.date.available2014-08-11T15:23:14Z
dc.date.issued2023
dc.description.abstractWild thyme aerial parts (Serpylli herba) are recognized as a valuable herbal product with antioxidant, anti-inflammatory, and antibacterial effects. Although pharmacopoeial regulations allow its collection exclusively from Thymus serpyllum, substitution with other species is frequent in current practice. This study analyzed the phenolic composition, antioxidant, and enzyme-inhibitory and antimicrobial activity of the hydroethanolic extracts obtained from five Romanian wild thyme species (Thymus alpestris, T. glabrescens, T. panonicus, T. pulcherimus and T. pulegioides). The analysis of individual phenolic constituents was performed through LC-ESI-DAD/MS2, while for the in vitro evaluation of antioxidant potential, TEAC, FRAP, DPPH, TBARS and OxHLIA assays were employed. The anti-enzymatic potential was tested in vitro against tyrosinase, alpha-glucosidase and acetylcholinesterase. High rosmarinic acid contents were quantified in all species (20.06 +/- 0.32-80.49 +/- 0.001 mg/g dry extract); phenolic acids derivatives (including salvianolic acids) were confirmed as the principal metabolites of T. alpestris and T. glabrescens, while eriodictyol-O-di-hexoside was found exclusively in T. alpestris. All species showed strong antioxidant potential and moderate anti-enzymatic effect against alpha-glucosidase and acetylcholinesterase, showing no anti-tyrosinase activity. This is the first detailed report on the chemical and biological profile of T. alpestris collected from Romanian spontaneous flora.por
dc.identifier.citationBabotă, Mihai; Frumuzachi, Oleg; Mafra, Isabel; Nicolescu, Alexandru; Dias, Maria Inês; Pinela, José; Barros, Lillian; Anibarro-Ortega, Mikel; Stojković, Dejan; Carevic, Tamara; Mocan, Andrei; Lopez, Victor; Crisan, Gianina (2023). Thymus species from romanian spontaneous flora as promising source of phenolic secondary metabolites with health-related benefits. Antioxidants. eISSN 2076-3921. 12:2, p. 1-19por
dc.identifier.doi10.3390/antiox12020390
dc.identifier.eissn2076-3921
dc.identifier.urihttp://hdl.handle.net/10198/10083
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherMDPI
dc.subjectThymus sp.
dc.subjectWild thyme
dc.subjectAntioxidant activity
dc.subjectEnzyme inhibition
dc.subjectAntimicrobial activity
dc.titleThymus species from romanian spontaneous flora as promising source of phenolic secondary metabolites with health-related benefitspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleAntioxidants
person.familyNameDias
person.familyNamePinela
person.familyNameBarros
person.familyNameAñibarro Ortega
person.givenNameMaria Inês
person.givenNameJosé
person.givenNameLillian
person.givenNameMikel
person.identifier469085
person.identifier.ciencia-id2A13-4BE6-C7CF
person.identifier.ciencia-id771C-2B43-B108
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-idC61D-DD88-73C7
person.identifier.orcid0000-0001-8744-7814
person.identifier.orcid0000-0001-7523-1637
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0002-2835-5079
person.identifier.ridM-8242-2013
person.identifier.ridB-4466-2014
person.identifier.ridJ-3600-2013
person.identifier.scopus-author-id54388787000
person.identifier.scopus-author-id54392272800
person.identifier.scopus-author-id35236343600
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication7ca8432b-e7f4-4116-a56e-9eba0d4403bd
relation.isAuthorOfPublication706cd9ff-065b-4c98-98a7-5c0a9e45adc4
relation.isAuthorOfPublication3af07ffe-f914-48ba-a5d5-efcf70fdce01
relation.isAuthorOfPublication7235cb7a-09a1-453b-b39b-52989046fab6
relation.isAuthorOfPublication.latestForDiscovery706cd9ff-065b-4c98-98a7-5c0a9e45adc4

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Thymus species from romanian spontaneous flora.pdf
Size:
1.51 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.75 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

CIMO - Artigos em Revistas Indexados à WoS/Scopus