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Antimicrobial activity, chemical composition and cytotoxicity of: Lentinus crinitus basidiocarp

2021Artigo científico Acesso aberto
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dc.contributor.authorBertéli, Míria B.D.
dc.contributor.authorBarros, Lillian
dc.contributor.authorReis, Filipa S.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorGlamočlija, Jasmina
dc.contributor.authorSoković, Marina
dc.contributor.authorValle, Juliana Silveira do
dc.contributor.authorLinde, Giani Andrea
dc.contributor.authorRuiz, Suelen Pereira
dc.contributor.authorColauto, Nelson Barros
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2021-11-23T09:40:06Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2021-11-23T09:40:06Z
dc.date.issued2021
dc.description.abstractLentinus crinitus (L.) Fr. (Basidiomycota: Polyporales) is a wild mushroom with several biotechnological applications; however, there are few studies on its chemical composition and antimicrobial activity. Therefore, this study aims to evaluate the chemical composition, cytotoxicity, and antimicrobial activity of L. crinitus basidiocarp. For that, its nutritional value (AOAC procedures) and its composition in some hydrophilic and lipophilic compounds (chromatographic techniques) were assessed. Moreover, the potential hepatotoxic effects were evaluated using a primary cell culture obtained from porcine liver, and its growth inhibitory capacity was also evaluated against four human tumour cell lines (spectrophotometric assays). The antimicrobial activity was evaluated by microdilution against eight bacteria and fungi. The basidiocarp has a high content of carbohydrates and, therefore, a relatively high energetic value. It is also rich in soluble sugars, β-tocopherol, phenolic acids, mainly p-hydroxybenzoic acid, and organic acids, mainly malic acid. L. crinitus did not show cytotoxicity in non-tumour cells, but it did not inhibit the growth of human tumour cell lines either. The basidiocarp has a wide antimicrobial activity, inhibiting the growth of different species of bacteria and fungi. It showed minimum bactericidal and fungicidal concentration values similar to or lower than those verified by commercial antibiotics or food additives used as preservatives. The antimicrobial activity was more evident against Listeria monocytogenes, Salmonella enterica, and Penicillium ochrochloron, followed by Aspergillus ochraceus and Trichoderma viride, when compared to the controls. The results obtained in this study showed that L. crinitus basidiocarp has great potential to be used by the industry without toxicity risks.en_EN
dc.description.sponsorshipThe authors thank Paranaense University, Fundação Araucária, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brazil (CAPES) -finance code 001-, and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) for the financial support and the fellowship. The authors also thank the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES to CIMO (UIDB/00690/2020); national funding by FCT, PI, through the institutional scientific employment program-contract for L. Barros’s contract, to the project Valor Natural for the contract of F. Reis (Mobilized Project Norte-01-0247- FEDER-024479), and the Ministry of Education, Science and Technological Development of Republic of Serbia (451-03-68/ 2020-14/200007).
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationBertéli, Míria Benetati Delgado; Barros, Lillian; Reis, Filipa S.; Ferreira, Isabel C.F.R.; Glamočlija, Jasmina; Sokovič, Marina; Valle, Juliana Silveira Do; Linde, Giani Andrea; Ruiz, Suelen Pereira; Colauto, Nelson Barros (2021). Antimicrobial activity, chemical composition and cytotoxicity of: Lentinus crinitus basidiocarp. Food and Function. ISSN 2042-6496. 12:15, p. 6780-6792en_EN
dc.identifier.doi10.1039/d1fo00656hen_EN
dc.identifier.issn2042-6496
dc.identifier.urihttp://hdl.handle.net/10198/24303
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationMountain Research Center
dc.titleAntimicrobial activity, chemical composition and cytotoxicity of: Lentinus crinitus basidiocarpen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameBarros
person.familyNameReis
person.familyNameFerreira
person.givenNameLillian
person.givenNameFilipa S.
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifier144781
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id391F-AFE1-64C7
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0002-9159-0530
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-3600-2013
person.identifier.ridI-2093-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id36982144400
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
relation.isAuthorOfPublication3af07ffe-f914-48ba-a5d5-efcf70fdce01
relation.isAuthorOfPublicationb8d384ae-2134-4735-93a6-0d2febbf9220
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