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Combined action of dietary-based approaches and therapeutic agents on cholesterol metabolism and main related diseases

2025Journal article Restricted access
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dc.contributor.authorBaptista, Eugénia
dc.contributor.authorPereira, Cláudia S.G.P.
dc.contributor.authorGarcía, Pablo A.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorBarreira, João C.M.
dc.date.accessioned2025-01-30T11:43:20Z
dc.date.available2025-01-30T11:43:20Z
dc.date.issued2025
dc.description.abstractDyslipidaemia is among the major causes of severe diseases and, despite being wellestablished, the hypocholesterolaemic therapies still face significant concerns about potential side effects (such as myopathy, myalgia, liver injury digestive problems, or mental fuzziness in some people taking statins), interaction with other drugs or specific foods. Accordingly, this review describes the latest developments in the most effective therapies to control and regulate dyslipidaemia. Scope and approach: Herein, the metabolic dynamics of cholesterol and their integration with the current therapies: statins, bile acid sequestrants, fibrates, niacin, proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, reconstituted high-density lipoprotein (rHDL), or anti-inflammatory and immunemodulating therapies), were compared focusing their effectiveness, patients’ adhesion and typical side-effects. Likewise, the interaction of these therapies with recommended dietary habits, focusing functional foods and nutraceuticals uptake were also considered. Key findings and conclusions: Since none of the current therapeutic alternatives represent an ideal solution (mainly due to side-effects or patients’ tolerance), the potential adjuvant action of selected diets (and other healthy habits) was proposed as a way to improve the cholesterol-lowering effectiveness, while reducing the adverse effects caused by dose-increase or continuous uptake of alternating therapeutic agents. In general, the relevance of well-adapted diets must be acknowledged and their potential effects must be exhorted among patients, who need to be aware of the associated multifactorial advantages.pt_PT
dc.description.sponsorshipThis work was supported by UID/QUI/50006/2019 with funding from FCT/MCTES through national funds. J.C.M. Barreira acknowledges Fundação para a Ciência e a Tecnologia (FCT) for his contract (CEECIND/04479/2017); C.S.G.P. Pereira thanks FCT for her PhD grant (2021.09490.BD).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBaptista, Eugénia C.M.S.; Pereira, Cláudia S.G.P.; García, Pablo A.; Ferreira, Isabel C.F.R.; Barreira, João C.M. (2025). Combined action of dietary-based approaches and therapeutic agents on cholesterol metabolism and main related diseases. Clinical Nutrition ESPEN. ISSN 2405-4577. 66, p. 51-68pt_PT
dc.identifier.doi10.1016/j.clnesp.2025.01.026pt_PT
dc.identifier.issn2405-4577
dc.identifier.urihttp://hdl.handle.net/10198/31100
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationNot Available
dc.relationBoosting immunity against viral infections with bioactive food constituents: validating differentiated leading trends through scholarly publications clustering maps
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCholesterol biosynthesis and homeostasispt_PT
dc.subjectMetabolic disorderspt_PT
dc.subjectDyslipidaemiapt_PT
dc.subjectAtherosclerosispt_PT
dc.subjectHealthy lifestylespt_PT
dc.subjectFunctional foods and nutraceuticalspt_PT
dc.titleCombined action of dietary-based approaches and therapeutic agents on cholesterol metabolism and main related diseasespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleNot Available
oaire.awardTitleBoosting immunity against viral infections with bioactive food constituents: validating differentiated leading trends through scholarly publications clustering maps
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FQUI%2F50006%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F04479%2F2017%2FCP1403%2FCT0002/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/2021.09490.BD/PT
oaire.citation.endPage68pt_PT
oaire.citation.startPage51pt_PT
oaire.citation.titleClinical Nutrition ESPENpt_PT
oaire.citation.volume66pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamCEEC IND 2017
oaire.fundingStreamPOR_NORTE
person.familyNameFerreira
person.familyNameBarreira
person.givenNameIsabel C.F.R.
person.givenNameJoão C.M.
person.identifier144781
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0003-4910-4882
person.identifier.orcid0000-0003-1233-0990
person.identifier.ridE-8500-2013
person.identifier.ridD-8269-2013
person.identifier.scopus-author-id36868826600
person.identifier.scopus-author-id54895546900
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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