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Toxicological and anti-tumor effects of a linden extract (Tilia platyphyllos Scop.) in a HPV16-transgenic mouse model

2021Artigo científico Acesso aberto
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dc.contributor.authorPatwal, Tiago
dc.contributor.authorNascimento-Gonçalves, Elisabete
dc.contributor.authorMacedo, Sara
dc.contributor.authorBorges, Inês
dc.contributor.authorGama, Adelina
dc.contributor.authorCosta, Rui Miguel Gil
dc.contributor.authorNeuparth, Maria João
dc.contributor.authorLanzarin, Germano
dc.contributor.authorVenâncio, Carlos
dc.contributor.authorFélix, Luís
dc.contributor.authorGaivão, Isabel
dc.contributor.authorAlvarado, Antonieta
dc.contributor.authorPires, Maria João
dc.contributor.authorBastos, Margarida M.S.M.
dc.contributor.authorMedeiros, Rui
dc.contributor.authorNogueira, António José M.
dc.contributor.authorBarros, Lillian
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorRosa, Eduardo
dc.contributor.authorOliveira, Paula A.
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2021-11-23T11:27:53Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2021-11-23T11:27:53Z
dc.date.issued2021
dc.description.abstractTilia platyphyllos Scop. is a popular broad-leaved tree, native to Central and Southern Europe. Hydroethanolic extracts rich in phenolic compounds obtained from T. platyphyllos Scop. have shown in vitro antioxidant, anti-inflammatory and antitumor properties. The aim of this work was to evaluate the therapeutic properties of a hydroethanolic extract obtained from T. platyphyllos in HPV16-transgenic mice. The animals were divided into eight groups according to their sex and phenotype. Four groups of female: HPV+ exposed to linden (HPV linden; n = 6), HPV+ (HPV water; n = 4), HPV- exposed to linden (WT linden; n = 5) and HPV- (WT water; n = 4) and four groups of male: HPV+ exposed to linden (HPV linden; n = 5), HPV+ (HPV water; n = 5), HPV- exposed to linden (WT linden; n = 5) and HPV- (WT water; n = 7). The linden (Tilia platyphyllos Scop.) extract was orally administered at a dose of 4.5 mg/10 mL per animal (dissolved in water) and changed daily for 33 days. The hydroethanolic extract of T. platyphyllos consisted of protocatechuic acid and (-)-epicatechin as the most abundant phenolic acid and flavonoid, respectively, and was found to be stable during the studied period. In two male groups a significant positive weight gain was observed but without association with the linden extract. Histological, biochemical, and oxidative stress analyses for the evaluation of kidney and liver damage support the hypothesis that the linden extract is safe and well-tolerated under the present experimental conditions. Skin histopathology does not demonstrate the chemopreventive effect of the linden extract against HPV16-induced lesions. The linden extract has revealed a favourable toxicological profile; however, additional studies are required to determine the chemopreventive potential of the linden extract. This journal isen_EN
dc.description.sponsorshipThis work was supported by the project IBERPHENOL, project number 0377_IBERPHENOL_6_E; Interact R&D project, operation number NORTE-01-0145-FEDER-000017, National Funds by FCT – Portuguese Foundation for Science and Technology, under the project UIDB/04033/2020 (CITAB), and project UIDB/ CVT/00772/2020 (CECAV) and the post-graduation grant SFRH/ BD/136747/2018 and 2020.04789.BD; the authors are also grateful to FCT, Portugal and FEDER under programme PT2020 for financial support to CIMO (UIDB/00690/2020) and L. Barros acknowledges the national funding by FCT, P. I., through the institutional scientific employment program-contract. The authors would like to thank Cantinho das Aromáticas organic farmers from Vila Nova de Gaia (Portugal) for providing the samples. This work was financially supported by: Base Funding - UIDB/00511/2020 of the Laboratory for Process Engineering, Environment, Biotechnology and Energy – LEPABE - funded by national funds through the FCT/MCTES (PIDDAC).
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationPatwal, Tiago; Nascimento-Gonçalves, Elisabete; Macedo, Sara; Borges, Inês; Gama, Adelina; M. Gil Da Costa, Rui; Neuparth, Maria J.; Lanzarin, Germano; Venâncio, Carlos; Félix, Luís; Gaivão, Isabel; Alvarado, Antonieta; Pires, Maria J.; Bastos, Margarida M.S.M.; Medeiros, Rui; Nogueira, António; Barros, Lillian; Ferreira, Isabel C.F.R.; Rosa, Eduardo; Oliveira, Paula A. (2021). Toxicological and anti-tumor effects of a linden extract (: Tilia platyphyllos Scop.) in a HPV16-transgenic mouse model. Food and Function. ISSN 2042-6496. 12:9, p. 4005-4014en_EN
dc.identifier.doi10.1039/d1fo00225ben_EN
dc.identifier.issn2042-6496
dc.identifier.urihttp://hdl.handle.net/10198/24344
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationUIDB/CVT/00772/2020
dc.relationCentre for the Research and Technology of Agro-Environmental and Biological Sciences
dc.relationalterado para: “Contribuição para o estudo do cancro da próstata: influência do estilo de vida num modelo animal Contribution to the study of prostate cancer: lifestyle influence in an animal model”. Estudo do impacto da atividade física no microambiente do cancro da próstata num modelo animal
dc.relationMountain Research Center
dc.relationLaboratory for Process Engineering, Environment, Biotechnology and Energy
dc.titleToxicological and anti-tumor effects of a linden extract (Tilia platyphyllos Scop.) in a HPV16-transgenic mouse modelen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberUIDB/04033/2020
oaire.awardNumberSFRH/BD/136747/2018
oaire.awardNumberUIDB/00690/2020
oaire.awardNumberUIDB/00511/2020
oaire.awardTitleCentre for the Research and Technology of Agro-Environmental and Biological Sciences
oaire.awardTitlealterado para: “Contribuição para o estudo do cancro da próstata: influência do estilo de vida num modelo animal Contribution to the study of prostate cancer: lifestyle influence in an animal model”. Estudo do impacto da atividade física no microambiente do cancro da próstata num modelo animal
oaire.awardTitleMountain Research Center
oaire.awardTitleLaboratory for Process Engineering, Environment, Biotechnology and Energy
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04033%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBD%2F136747%2F2018/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00511%2F2020/PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamFARH
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameNogueira
person.familyNameBarros
person.familyNameFerreira
person.givenNameAntónio José M.
person.givenNameLillian
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifier144781
person.identifier.ciencia-id8A11-794E-36BD
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0001-8912-7355
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-3600-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id55865568268
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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