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Tamarindus indica sub-products as potential tools for simultaneous management of diabetes and obesity

2025Artigo científico Acesso aberto
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datacite.subject.fosCiências Agrárias::Biotecnologia Agrária e Alimentar
datacite.subject.fosEngenharia e Tecnologia::Engenharia Química
datacite.subject.sdg04:Educação de Qualidade
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
dc.contributor.authorSouza, Gustavo Henrique
dc.contributor.authorSilva, Beatriz Paes
dc.contributor.authorViana Neto, Gabriel Arcanjo
dc.contributor.authorFinimundy, Tiane C.
dc.contributor.authorSantos, Thalita Faleiro Demito
dc.contributor.authorBueno, Paulo Sergio Alves
dc.contributor.authorSouza, Felipe de Oliveira
dc.contributor.authorPilau, Eduardo J.
dc.contributor.authorBarros, Lillian
dc.contributor.authorComar, Jurandir F.
dc.contributor.authorBracht, Livia
dc.contributor.authorPeralta, Rosane M.
dc.contributor.authorBracht, Adelar
dc.contributor.authorSá-Nakanishi, Anacharis B.
dc.date.accessioned2026-02-26T17:12:33Z
dc.date.available2026-02-26T17:12:33Z
dc.date.issued2025
dc.description.abstractAiming at valorizing industrial wastes of tamarind, the present work evaluated the actions of seed, leaf and peel extracts on starch and fat absorption through starch and triglyceride tolerance tests in mice. The actions of all extracts on the α-amylase and lipase were also characterized using classical kinetic assays. All extracts inhibited starch digestion in vivo, but the seed extract was the most effective one with an ID50 of 151.4 mg kg−1. The mechanism behind this inhibition probably involves the pancreatic α-amylase, which was strongly inhibited by the seed extract under in vitro conditions (IC50 = 13.3 μg mL−1) and much less strongly by the leaf and peel extracts (IC50 values in the vicinity of 400 μg mL−1). The pancreatic lipase, conversely, was inhibited solely by the seed extract, with an IC50 of 31.5 μg mL−1. As a consequence of this property, the seed extract also inhibited triglyceride absorption, as indicated by olive oil tolerance tests, which revealed an ID50 of 214.9 mg kg−1. The seed extract also possessed the strongest antioxidant capacity and the highest content in phenolic groups. Chemical analyses revealed that all extracts present a great variety of phenolic compounds and that the seed extract possesses at least 5 unique compounds (ursodiol, masoprocol, lenticin, chenodeoxycolic acid and 13-keto-9Z,11E-octadecadienoic acid), which, according to docking studies, could be involved in the inhibition of both α-amylase and lipase. The overall conclusion is that the tamarind seed extract displays great potential for being used in the management of obesity and diabetes.eng
dc.description.sponsorshipThis study was financially supported by a grant from the Council for Scientific and Technological Development (CNPq; 304090/2016-6), and the Araucaria Foundation (FA160/2022), Brazil. The authors are grateful to the Council for Scientific and Technological Development (CNPq), the Araucaria Foundation (FA), the Coordination for the Improvement of Higher Education Personnel (CAPES), the Complex of Research Support Centers of the State University of Maringá (COMCAP-UEM), the State University of Maringá (UEM), the Foundation for Science and Technology (FCT, Portugal) for financial support from the FCT/MCTES (PIDDAC) national funds to CIMO (UIDB/00690/2020 (https://doi.org/10.54499/UIDB/00690/2020) and UIDP/00690/2020 (https://doi.org/10.54499/UIDP/00690/2020)) and SusTEC (LA/P/0007/2020 (https://doi.org/10.54499/LA/P0007/2020)), and for the individual scientific employment program contract for the L. Barros contract (CEEC-INST, https://doi.org/10.54499/CEECINST/00107/2021/CP2793/CT0002).
dc.identifier.citationSouza, Gustavo Henrique; Silva, Beatriz Paes; Viana Neto, Gabriel Arcanjo; Finimundy, Tiane C.; Santos, Thalita Faleiro Demito; Bueno, Paulo Sergio Alves; Souza, Felipe de Oliveira; Pilau, Eduardo J.; Barros, Lillian; Comar, Jurandir F.; Bracht, Livia; Peralta, Rosane M.; Bracht, Adelar; Sá-Nakanishi, Anacharis B. (2025). Tamarindus indica sub-products as potential tools for simultaneous management of diabetes and obesity. Food and Function. ISSN 2042-6496. 16:5, p. 1969-1991
dc.identifier.doi10.1039/d4fo04536j
dc.identifier.issn2042-6496
dc.identifier.issn2042-650X
dc.identifier.urihttp://hdl.handle.net/10198/35874
dc.language.isoeng
dc.peerreviewedyes
dc.publisherRoyal Society of Chemistry
dc.relationMountain Research Center
dc.relationAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
dc.relation.ispartofFood & Function
dc.rights.urihttp://creativecommons.org/licenses/by-nd/4.0/
dc.subjectAlpha-amylases
dc.subjectAnimals
dc.subjectAntioxidants
dc.subjectDiabetes mellitus
dc.subjectHumans
dc.subjectLipase
dc.subjectMale
dc.subjectMice
dc.subjectObesity
dc.subjectPlant extracts
dc.subjectPlant leaves
dc.subjectSeeds
dc.subjectStarch
dc.subjectTamarindus
dc.subjectTriglycerides
dc.titleTamarindus indica sub-products as potential tools for simultaneous management of diabetes and obesityeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardTitleAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0007%2F2020/PT
oaire.citation.endPage1991
oaire.citation.issue5
oaire.citation.startPage1969
oaire.citation.titleFood & Function
oaire.citation.volume16
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameFinimundy
person.familyNameBarros
person.givenNameTiane C.
person.givenNameLillian
person.identifier469085
person.identifier.ciencia-id2F18-67B1-776A
person.identifier.ciencia-id9616-35CB-D001
person.identifier.orcid0000-0003-3516-0795
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridJ-3600-2013
person.identifier.scopus-author-id35236343600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isAuthorOfPublication4f8767d4-4e62-4550-9b35-740cb2f672da
relation.isAuthorOfPublication3af07ffe-f914-48ba-a5d5-efcf70fdce01
relation.isAuthorOfPublication.latestForDiscovery4f8767d4-4e62-4550-9b35-740cb2f672da
relation.isProjectOfPublication29718e93-4989-42bb-bcbc-4daff3870b25
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