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Asymmetry of red blood cell motions in a microchannel with a diverging and converging bifurcation

2011Journal article Open access
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dc.contributor.authorLeble, Vladimir
dc.contributor.authorLima, Rui A.
dc.contributor.authorDias, Ricardo P.
dc.contributor.authorFernandes, Carla S.
dc.contributor.authorIshikawa, Takuji
dc.contributor.authorImai, Yohsuke
dc.contributor.authorYamaguchi, Takami
dc.date.accessioned2012-06-01T11:00:40Z
dc.date.available2012-06-01T11:00:40Z
dc.date.issued2011
dc.description.abstractIn microcirculation, red blood cells (RBCs) flowing through bifurcations may deform considerably due to combination of different phenomena that happen at the micro-scale level, such as: attraction effect, high shear and extensional stress, all of which may influence the rheological properties and flow behavior of blood. Thus, it is important to investigate in detail the behavior of blood flow occurring at both bifurcations and confluences. In the present paper, by using a micro-PTV system, we investigated the variations of velocity profiles of two working fluids flowing through diverging and converging bifurcations - human red blood cells suspended in dextran 40 with about 14% of haematocrit level (14Hct) and pure water seeded with fluorescent trace particles. All the measurements were performed in the center plane of rectangular microchannels using a constant flow rate of about 3.0×10-12 m3/s. Moreover, the experimental data was compared with numerical results obtained for Newtonian incompressible fluid. The behavior of RBCs was asymmetric at the divergent and convergent side of the geometry, whereas the velocities of tracer particles suspended in pure water were symmetric and well described by numerical simulation. The formation of a red cell-depleted zone immediately downstream of the apex of the converging bifurcation was observed and its effect on velocity profiles of RBCs flow has been investigated. Conversely, a cell-depleted region was not formed around the apex of the diverging bifurcation and as a result the adhesion of RBCs to the wall surface was enhanced in this region.por
dc.description.sponsorshipThe authors acknowledge the financial support provided by: 2007 GlobalCOE Program, Japan; PTDC/SAU-BEB/108728/2008, PTDC/SAU-BEB/105650/2008, and PTDC/EME-MFE/099109/2008 from the FCT (Science and Technology Foundation) and COMPETE, Portugal.
dc.identifier.citationLeble, Vladimir; Lima, R.; Dias, Ricardo P.; Fernandes, Carla S.; Ishikawa, Takuji ; Imai, Yohsuke; Yamaguchi, Takami (2011). Asymmetry of red blood cell motions in a microchannel with a diverging and converging bifurcation. Biomicrofluidics. ISSN1932-1058. 5:4, p.044120-1- 044120-15.por
dc.identifier.doi10.1063/1.3672689
dc.identifier.issn1932-1058
dc.identifier.urihttp://hdl.handle.net/10198/7003
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherAmerican Institute of Physicspor
dc.relationHemo-Networks - Experimental and computational investigations of the factors influencing blood flow in microvascular networks.
dc.relationANEURYSM - Hemodynamic Study in Cerebral Aneurysms
dc.titleAsymmetry of red blood cell motions in a microchannel with a diverging and converging bifurcationpor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHemo-Networks - Experimental and computational investigations of the factors influencing blood flow in microvascular networks.
oaire.awardTitleANEURYSM - Hemodynamic Study in Cerebral Aneurysms
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FSAU-BEB%2F108728%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FSAU-BEB%2F105650%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FEME-MFE%2F099109%2F2008/PT
oaire.citation.endPage044120-15por
oaire.citation.issue5por
oaire.citation.startPage044120-1por
oaire.citation.titleBiomicrofluidicspor
oaire.fundingStream5876-PPCDTI
oaire.fundingStream5876-PPCDTI
oaire.fundingStream5876-PPCDTI
person.familyNameLima
person.familyNameDias
person.familyNameFernandes
person.givenNameRui A.
person.givenNameRicardo P.
person.givenNameCarla S.
person.identifier.ciencia-idEE12-C3FB-349D
person.identifier.ciencia-idF319-3D67-9DB7
person.identifier.orcid0000-0003-3428-637X
person.identifier.orcid0000-0003-1503-998X
person.identifier.orcid0000-0002-3138-7493
person.identifier.ridH-5157-2016
person.identifier.ridA-4269-2015
person.identifier.scopus-author-id18437397800
person.identifier.scopus-author-id7102885151
person.identifier.scopus-author-id8253740700
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typearticlepor
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