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Lipid composition optimization in spray congealing technique and testing with curcumin-loaded microparticles

2021Journal article Open access
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dc.contributor.authorSorita, Guilherme Dallarmi
dc.contributor.authorSantamaria-Echart, Arantzazu
dc.contributor.authorGozzo, Ângela Maria
dc.contributor.authorGonçalves, Odinei Hess
dc.contributor.authorLeimann, Fernanda Vitória
dc.contributor.authorBona, Evandro
dc.contributor.authorManrique, Yaidelin A.
dc.contributor.authorFernandes, Isabel P.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorBarreiro, M.F.
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2021-11-22T14:46:38Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2021-11-22T14:46:38Z
dc.date.issued2021
dc.description.abstractSpray-congealing, a technique based on the fast solidification of sprayed molten lipids, is considered a novel strategy to encapsulate natural products. Among others, it is a safe, low cost, fast and reproducible technique, with rising interest for several applications (e.g. food applications). One of the key parameters for the application of this technique is the lipid solidification temperature, which can be modulated by optimizing the lipid composition. In this work, three lipid components (beeswax, carnauba wax, and medium-chain triglycerides (Miglyol 812)) were selected, and the mixture composition modelled using a simplex-centroid experimental design. Three different lipid compositions were chosen to validate the proposed model, then tested in the preparation of curcumin-loaded microparticles (1.5%, w/w). The produced microparticles were analysed in terms of colour, morphology, particle size, encapsulation efficiency and load, physicochemical, crystalline, and thermal properties. Results evidenced that microparticle's properties, including encapsulation efficiency, vary according to the used lipid mixture, supporting their tailoring role. This fact brings advantages in the design of microencapsulation systems based on spray congealing processes, broadening their applicability. Moreover, lipid composition optimisation was proved to be an important tool to precede the development of spray-congealing applications.en_EN
dc.description.sponsorshipThis work was financially supported by: CIMO (UIDB/00690/2020), and Associate Laboratory LSRE-LCM (UIDB/50020/2020) funded by national funds through FCT/MCTES (PIDDAC), and European Regional Development Fund (ERDF) through the Regional Operational Program North 2020, within the scope of Project Mobilizador Norte-01-0247-FEDER-024479 (ValorNatural). FCT, PI, through the institutional scientific employment program-contract for I.P. Fernandes contract through the celebration of program-contract foreseen in No. 4, 5 and 6 of article 23 of Decree-Law No. 57/2016, of 29th August, amended by Law No. 57/2017, of 19th July; and Valor Natural project for the contract of A. Santamaria-Echart (Project Norte-01-0247-FEDER- 024479). This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationSorita, G. D.; Santamaria-Echart, A.; Gozzo, A. M.; Gonçalves, O. H.; Leimann, F. V.; Bona, E.; Manrique, Y.; Fernandes, I. P.M.; Ferreira, I. C.F.R.; Barreiro, M. F. (2021). Lipid composition optimization in spray congealing technique and testing with curcumin-loaded microparticles. Advanced Powder Technology. ISSN 0921-8831.en_EN
dc.identifier.doi10.1016/j.apt.2021.03.028en_EN
dc.identifier.issn0921-8831
dc.identifier.urihttp://hdl.handle.net/10198/24273
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationMountain Research Center
dc.relationLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
dc.subjectCurcuminen_EN
dc.subjectLipid composition optimizationen_EN
dc.subjectLipid-based microparticlesen_EN
dc.subjectSimplex-centroid designen_EN
dc.subjectSpray congealingen_EN
dc.titleLipid composition optimization in spray congealing technique and testing with curcumin-loaded microparticlesen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardTitleLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50020%2F2020/PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameSantamaria-Echart
person.familyNameGonçalves
person.familyNameLeimann
person.familyNameFernandes
person.familyNameFerreira
person.familyNameBarreiro
person.givenNameArantzazu
person.givenNameOdinei Hess
person.givenNameFernanda Vitória
person.givenNameIsabel P.
person.givenNameIsabel C.F.R.
person.givenNameFilomena
person.identifier144781
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person.identifier.orcid0000-0003-0107-7301
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person.identifier.orcid0000-0001-6230-9597
person.identifier.orcid0000-0002-0069-4503
person.identifier.orcid0000-0003-4910-4882
person.identifier.orcid0000-0002-6844-333X
person.identifier.ridL-1552-2016
person.identifier.ridE-8500-2013
person.identifier.ridL-9802-2014
person.identifier.scopus-author-id56725697700
person.identifier.scopus-author-id9335958400
person.identifier.scopus-author-id26323585300
person.identifier.scopus-author-id36868826600
person.identifier.scopus-author-id57188719717
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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