Repository logo
 
Publication

Risk factors for sporadic norovirus infection: a systematic review and meta-analysis

2020Journal article Open access
Simple item page
dc.contributor.authorThébault, Anne
dc.contributor.authorDavid, Julie
dc.contributor.authorKooh, Pauline
dc.contributor.authorCadavez, Vasco
dc.contributor.authorGonzales-Barron, Ursula
dc.contributor.authorPavio, Nicole
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2021-02-27T18:06:06Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2021-02-27T18:06:06Z
dc.date.issued2020
dc.description.abstractNorovirus is responsible for 20% of acute gastroenteritis worldwide. The fecal-oral route of transmission is known, but we proposed a first attempt to identify the relative importance of different sources and vehicles for sporadic cases using meta-analysis models. Case-control and cohort/cross-sectional studies were systematically reviewed and analyzed to assess the main risk factors associated with sporadic norovirus infections. Suitable scientific articles were identified through systematic literature search and subjected to a methodological quality assessment. Mixed-effects meta-analyses models were adjusted by population type to appropriate risk factor categories. The quality assessment stage led to include 14 primary studies conducted between 1993 and 2014. From these, eight studies investigated exposures in children/infants, and eight concerned the mixed population. The meta-analysis confirmed the oro-fecal route for norovirus infections, with the person-to-person transmission (pooled OR=3.002; 95% CI: [2.502 -3.060] in mixed population), and the lack of personal hygiene (pooled OR=2.329; 95% CI: [1.048 -5.169]). The meta-analysis also enlightened the role of indirect transmission through the environment with pathways like untreated drinking water (mixed population), with a pooled OR=2.680 (95% CI: [1.081-6.643]) and farm environment (children population). Indirect transmission also involved the food pathway, which was finally found significant with consumption of seafood (mixed population) (pooled OR=2.270; 95% CI: [1.299-3.968]) and composite food (eating outside/uncooked mixed and young population) (pooled OR=4.541; 95% CI: [3.461-5.958]). These results are coherent with the findings from studies on outbreaks. However, a too broad definition of exposure factors limited the interpretation of results, as occurred with the seafood pathways that combined fish and shellfish. Other factors such as consumption of Food-handled products or the type of drinking water deserveE to be better investigated. Furthermore, better harmonization in case definition and appropriate case-control or cross-sectional studies would allow better addressing sporadic cases risk factors, especially for susceptible populations, such as children, elderly or immunosuppressed persons.en_EN
dc.description.sponsorshipU. Gonzales-Barron and V. Cadavez are grateful to the Foundation for Food Science and Technology (FCT, Portugal) and FEDER under Programme PT2020 for financial support to CIMO (UID/AGR/00690/ 2019). U. Gonzales-Barron thanks the national funding by FCT, P.I., through the Institutional Scientific Employment Program contract.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationThébault, Anne; David, Julie; Kooh, Pauline; Cadavez, Vasco; Gonzales-Barron, Ursula; Pavio, Nicole (2020). Risk factors for sporadic norovirus infection: a systematic review and meta-analysis. Microbial Risk Analysis. ISSN 2352-3522. p. 1-10en_EN
dc.identifier.doi10.1016/j.mran.2020.100135en_EN
dc.identifier.urihttp://hdl.handle.net/10198/23430
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationMountain Research Centre
dc.subjectCase-control studiesen_EN
dc.subjectMeta-regressionen_EN
dc.subjectNorovirusen_EN
dc.subjectOdds-ratioen_EN
dc.subjectResearch synthesisen_EN
dc.titleRisk factors for sporadic norovirus infection: a systematic review and meta-analysisen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMountain Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FAGR%2F00690%2F2019/PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameCadavez
person.familyNameGonzales-Barron
person.givenNameVasco
person.givenNameUrsula
person.identifierR-000-HDG
person.identifier.ciencia-id441B-01AB-A12E
person.identifier.ciencia-id0813-C319-B62A
person.identifier.orcid0000-0002-3077-7414
person.identifier.orcid0000-0002-8462-9775
person.identifier.ridA-3958-2010
person.identifier.scopus-author-id9039121900
person.identifier.scopus-author-id9435483700
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
relation.isAuthorOfPublication57b410e9-f6b7-42ff-ab3d-b526278715eb
relation.isAuthorOfPublication17c6b98f-4fb5-41d3-839a-6f77ec70021a
relation.isAuthorOfPublication.latestForDiscovery17c6b98f-4fb5-41d3-839a-6f77ec70021a
relation.isProjectOfPublicationd6683ba1-d253-48e4-968e-35106ce7b750
relation.isProjectOfPublication.latestForDiscoveryd6683ba1-d253-48e4-968e-35106ce7b750

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
92.pdf
Size:
1.92 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.75 KB
Format:
Plain Text
Description:
Download

Collections

CIMO - Artigos em Revistas Indexados à WoS/Scopus