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Development of hydrosoluble gels with Crataegus monogyna extracts for topical application: evaluation of antioxidant activity of the final formulations

2013Journal article Open access
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dc.contributor.authorBarreira, João C.M.
dc.contributor.authorRodrigues, Sandra
dc.contributor.authorCarvalho, Ana Maria
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2012-11-05T15:44:08Z
dc.date.available2012-11-05T15:44:08Z
dc.date.issued2013
dc.description.abstractCrataegus monogyna, commonly known as hawthorn, is notorious for having different ethnopharmacological applications. The antioxidant activity of methanolic extracts from its flowers and fruits in several stages of development was formerly reported by us. Therefore it is believable that the extracts of its botanical parts might have great potential to be incorporated in innovative pharmaceutical formulations. Accordingly, several paraben free, carbopol 940 based semisolid formulations were prepared with different hawthorn parts extracts. The antioxidant properties of ethanolic and aqueous hawthorn extracts, as well as their corresponding hydrosoluble gels, were screened. Ethanolic extracts proved to be more effective, while flowers and unripe fruits were the most bioactive hawthorn parts. The prepared hydrosoluble gels, that presented an adequate consistency, a pleasant colour and a non greasy texture, kept almost entirely the antioxidant activity exhibited by the extracts from which they were prepared. In addition, the hydrosoluble gels were tested and promptly absorbed by the skin and did not show significant pH alterations during the 90 days of observation. Despite the need of further tests (viscosity, extrudability, spreadability or transepidermal water loss), the prepared formulations demonstrate interesting attributes to be explored as potential dermopharmaceutical products.
dc.identifier.citationBarreira, João C.M.; Rodrigues, Sandra; Carvalho, Ana Maria; Ferreira, Isabel C.F.R. (2013). Development of hydrosoluble gels with Crataegus monogyna extracts for topical application: evaluation of antioxidant activity of the final formulations. Industrial Crops and Products. ISSN 0926-6690. 43, p. 175-180
dc.identifier.doi10.1016/j.indcrop.2012.05.034
dc.identifier.issn0926-6690
dc.identifier.urihttp://hdl.handle.net/10198/7715
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.relationStrategic Project - UI 690 - 2011-2012
dc.relationBIOACTIVE PROPERTIES & CYTOPROTECTIVE POTENTIAL OF NATURAL EXTRACTS/INDIVIDUAL COMPOUNDS: APPLICATION OF SINGLE CELL GEL ELECTROPHORESIS AND OTHER BIOCHEMICAL, CHEMICAL AND ELECTROCHEMICAL ASSAYS
dc.subjectHydrosoluble gels
dc.subjectHawthorn
dc.subjectEthnopharmacology
dc.subjectAntioxidant activity
dc.subjectBioactive compounds
dc.titleDevelopment of hydrosoluble gels with Crataegus monogyna extracts for topical application: evaluation of antioxidant activity of the final formulationspor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 690 - 2011-2012
oaire.awardTitleBIOACTIVE PROPERTIES & CYTOPROTECTIVE POTENTIAL OF NATURAL EXTRACTS/INDIVIDUAL COMPOUNDS: APPLICATION OF SINGLE CELL GEL ELECTROPHORESIS AND OTHER BIOCHEMICAL, CHEMICAL AND ELECTROCHEMICAL ASSAYS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0690%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F72802%2F2010/PT
oaire.citation.endPage180por
oaire.citation.startPage175por
oaire.citation.titleIndustrial Crops and Productspor
oaire.citation.volume42por
oaire.fundingStream6817 - DCRRNI ID
person.familyNameBarreira
person.familyNameRodrigues
person.familyNameCarvalho
person.familyNameFerreira
person.givenNameJoão C.M.
person.givenNameSandra
person.givenNameAna Maria
person.givenNameIsabel C.F.R.
person.identifierID G-7399-2011
person.identifier144781
person.identifier.ciencia-id651F-D964-32E1
person.identifier.ciencia-idD31A-35AF-E2A9
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0003-1233-0990
person.identifier.orcid0000-0003-3301-1729
person.identifier.orcid0000-0001-5508-5935
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridD-8269-2013
person.identifier.ridC-6486-2008
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id54895546900
person.identifier.scopus-author-id14048942500
person.identifier.scopus-author-id20336503900
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typearticlepor
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