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Phytochemicals and bioactive properties of Ilex paraguariensis: an in-vitro comparative study between the whole plant, leaves and stems

2015Journal article Open access
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dc.contributor.authorSouza, Aloisio Henrique Pereira de
dc.contributor.authorCorrêa, Rúbia C.G.
dc.contributor.authorBarros, Lillian
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorSantos-Buelga, Celestino
dc.contributor.authorPeralta, Rosane M.
dc.contributor.authorBracht, Adelar
dc.contributor.authorMatsushita, Makoto
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2016-01-19T11:39:26Z
dc.date.available2016-01-19T11:39:26Z
dc.date.issued2015
dc.description.abstractLeaves, stems and whole plant of Ilex paraguariensis (yerba mate) were characterized in terms of their chemical composition and biological activities in order to determine which part of the plant is more interesting to develop bioactive formulations. The yerba mate samples contain at least five free sugars, five organic acids, eighteen fatty acids, one tocopherol, nine hydroxycinnamoyl derivatives and two flavonols. The leaves extract revealed the highest antioxidant activity, correlating with its highest levels of phenolic compounds. By contrast, the stems extract showed the highest anti-inflammatory potential and was also the most potent against MCF-7 and HepG2 cell lines, probably due to the presence of other phytochemicals. The absence of hepatotoxicity of the extracts was confirmed in porcine liver primary cells. Although the yerba mate extracts have been widely studied, this report shows for the first time the distinct potentialities of each individual part of the plant.pt_PT
dc.description.sponsorshipThe authors are grateful to Foundation for Science and Technology (FTC, Portugal) for financial support to CIMO (Pest-OE/AGR/UI0690/2014), L. Barros research contract (“Compromisso para a Ciência”) and R.C. Calhelha grant (SFRH/BPD/68344/2010). R.C.G. Correa and A. H. P. Souza thank CAPES Foundation, Ministry of Education of Brazil (CAPES fellows, process numbers BEX 3974/14-6 and BEX 3972/14-03, respectively). The authors also thank to A. Fernandes for all the support in some of the laboratorial work.pt_PT
dc.identifier.citationSouza, Aloisio H.P.; Corrêa, Rúbia C.G.; Barros, Lillian; Calhelha, Ricardo C.; Santos-Buelga, Celestino; Peralta, Rosane M.; Bracht, Adelar; Matsushita, Makoto; Ferreira, Isabel C.F.R. (2015). Phytochemicals and bioactive properties of Ilex paraguariensis: An in-vitro comparative study between the whole plant, leaves and stems. Food Research International. ISSN 0963-9969. 78, p. 286-294pt_PT
dc.identifier.doi10.1016/j.foodres.2015.09.032pt_PT
dc.identifier.issn0963-9969
dc.identifier.urihttp://hdl.handle.net/10198/12635
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationNEW ANTITUMOR AND/OR ANTI-ANGIOGENIC HETEROCYCLIC COMPOUNDS: SYNTHESIS, MOLECULAR MODELLING AND INHIBITION ENZYMATIC ASSAYS USING TYROSINE KINASE MEMBRANE GROWTH FACTOR RECEPTORS
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnti-inflammatory activitypt_PT
dc.subjectAntioxidant activitypt_PT
dc.subjectCytotoxicitypt_PT
dc.subjectPhytochemicalspt_PT
dc.subjectYerba matept_PT
dc.titlePhytochemicals and bioactive properties of Ilex paraguariensis: an in-vitro comparative study between the whole plant, leaves and stemspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleNEW ANTITUMOR AND/OR ANTI-ANGIOGENIC HETEROCYCLIC COMPOUNDS: SYNTHESIS, MOLECULAR MODELLING AND INHIBITION ENZYMATIC ASSAYS USING TYROSINE KINASE MEMBRANE GROWTH FACTOR RECEPTORS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/PEst-OE%2FAGR%2FUI0690%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBPD%2F68344%2F2010/PT
oaire.citation.endPage294pt_PT
oaire.citation.startPage286pt_PT
oaire.citation.titleFood Research Internationalpt_PT
oaire.citation.volume78pt_PT
oaire.fundingStream5876
oaire.fundingStreamFARH
person.familyNameCarvalho Gomes Corrêa
person.familyNameBarros
person.familyNameCalhelha
person.familyNameFerreira
person.givenNameRúbia
person.givenNameLillian
person.givenNameRicardo C.
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifier144781
person.identifier.ciencia-id6C1F-2818-CBB5
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0003-0269-4344
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-3600-2013
person.identifier.ridJ-2172-2014
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id37661286600
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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