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Risk factors for sporadic cryptosporidiosis: a systematic review and meta-analysis

2020Journal article Open access
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dc.contributor.authorKooh, Pauline
dc.contributor.authorThébault, Anne
dc.contributor.authorCadavez, Vasco
dc.contributor.authorGonzales-Barron, Ursula
dc.contributor.authorVillena, Isabelle
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2020-06-22T10:18:50Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2020-06-22T10:18:50Z
dc.date.issued2020
dc.description.abstractCryptosporidium spp. is an important cause of gastrointestinal disease worldwide, responsible for 69 million cases of illness in 2016. Information on the sources and transmission pathways of human cryptosporidiosis results mainly from outbreak investigations. A systematic review and a meta-analysis of case-control and cohort studies were performed to determine the main risk factors associated with sporadic cryptosporidiosis. Suitable scientific articles were identified through a systematic literature search and subjected to a methodological quality assessment. From each study, odds ratio (OR) measures were extracted or calculated, as well as study characteristics such as population type, design, type of model and risk factor hierarchy. Mixed-effects meta-analysis models were adjusted by population type to appropriate data partitions. From 1985 identified references, the quality assessment stage was passed by 57 cohort and case-control studies focusing on sporadic cryptosporidiosis. The eligible studies were conducted between 1983 and 2016 and provided 568 OR categorized for meta-analysis. This meta-analysis identified travel, immunocompromising conditions, contact with infected humans, waterborne transmission (contact with recreational waters, wastewater, and consumption of untreated drinking water), contact with animals and food consumption as the relevant risk factors for sporadic cryptosporidiosis. With regards to food exposures, consumption of meat, dairy products (raw milk) and dishes consumed outside home were found significantly associated with cryptosporidiosis. The consumption of poorly washed fruits and vegetables significantly increases ORs. This meta-analysis reveals that some potential sources of Cryptosporidium such as shellfish or vegetables are under-investigated. Future case-control studies for sporadic cryptosporidiosis should include population at risk, and investigate other potential sources in relation to the genotype and the subtype of Cryptosporidium spp.
dc.description.sponsorshipThe authors would like to thank ANSES staff and the members of the ANSES Working Group on Source Attribution of Foodborne Diseases: Moez Sanaa, Laurence Watier, Jean Christophe Augustin, Frédéric Carlin, Julie David, Philippe Fravalo, Laurent Guillier, Nathalie Jourdan-Da Silva, Alexandre Leclercq, Lapo Mughini-Gras, Nicole Pavio. Ursula Gonzales-Barron and Vasco Cadavez are grateful to the Foundation for Food Science and Technology (FCT, Portugal) and FEDER under Programme PT2020 for financial support to CIMO UID/AGR/00690/2019.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationKooh, Pauline; Thébault, Anne; Cadavez, Vasco; Gonzales-Barron, Ursula; Villena, Isabelle (2020). Risk factors for sporadic cryptosporidiosis: a systematic review and meta-analysis. Microbial Risk Analysis. ISSN 352-3522. p. 1-14en_EN
dc.identifier.doi10.1016/j.mran.2020.100116en_EN
dc.identifier.urihttp://hdl.handle.net/10198/22342
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationMountain Research Centre
dc.subjectCase-control studiesen_EN
dc.subjectCohort studiesen_EN
dc.subjectCryptosporidiumen_EN
dc.subjectMeta-regressionen_EN
dc.subjectResearch synthesisen_EN
dc.titleRisk factors for sporadic cryptosporidiosis: a systematic review and meta-analysisen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMountain Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FAGR%2F00690%2F2019/PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameCadavez
person.familyNameGonzales-Barron
person.givenNameVasco
person.givenNameUrsula
person.identifierR-000-HDG
person.identifier.ciencia-id441B-01AB-A12E
person.identifier.ciencia-id0813-C319-B62A
person.identifier.orcid0000-0002-3077-7414
person.identifier.orcid0000-0002-8462-9775
person.identifier.ridA-3958-2010
person.identifier.scopus-author-id9039121900
person.identifier.scopus-author-id9435483700
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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relation.isAuthorOfPublication17c6b98f-4fb5-41d3-839a-6f77ec70021a
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