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Effect of hidroethanolic extract of Lavandula pedunculata (mill.) Cav. On morphometric parameters in HPV-16 trangenic mice

2021Conference object Open access
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dc.contributor.authorNascimento-Gonçalves, Elisabete
dc.contributor.authorFerreira, Teresa
dc.contributor.authorMoutinho, Magda S.S.
dc.contributor.authorPires, Maria João
dc.contributor.authorBastos, Margarida M.S.M.
dc.contributor.authorMedeiros, Rui
dc.contributor.authorNogueira, António José M.
dc.contributor.authorBarros, Lillian
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorCosta, Rui Miguel Gil
dc.contributor.authorOliveira, Paula A.
dc.date.accessioned2023-02-23T15:30:04Z
dc.date.available2023-02-23T15:30:04Z
dc.date.issued2021
dc.description.abstractLavandula penduculata (Mill.) Cav., common English name French lavender, belongs to the Lamiaceae family and has been used as a medicinal plant in infusions for respiratory and digestive systems and as a therapeutic agent with antiseptic action for cleaning wounds [1,2]. The K14HPV16 mice is a skin squamous carcinoma model that can be used to test the antitumoral properties of several chemical and natural products [3]. The aim of this work was to evaluate the effect of the hydroethanolic French lavender extract (FLE) on body weight, relative organs weights, food and water consumption in an HPV-16-transgenic mice model. The extract was obtained from a maceration with ethanol/water (80:20, v/v), and the phenolic composition was determined through HPLC-DAD-ESI/MS. Twenty-eight male mice were randomly divided into four groups (n=7/group) according to their genotype: group I (HPV16- control); II (HPV16- FLE); III (HPV16+ control) and IV (HPV16+ FLE). The FLE was administrated orally in drinking water at 6.8 mg/10mL/animal to animals from groups II and IV and changed every 4 days. The animals were kept under controlled conditions such as temperature, light and humiditypt_PT
dc.description.sponsorshipThis work was supported by European Investment Funds by FEDER/ COMPETE/POCI - Operational Competitiveness and Internationalization Program and National Funds by FCT - Portuguese Foundation for Science and Technology, under the projects Project UIDB/04033/2020 (CITAB), and PhD fellowship SFRH/BD/136747/2018 and 2020.04789.BD. The authors are also grateful to FCT for financial support through national funds FCT/MCTES to CIMO (UIDB/00690/2020). L. Barros thanks FCT, P.I for her contract through the institutional scientific employment program. This work was also funded by the European Regional Development Fund (ERDF) through the Regional Operational Program North 2020, within the scope of Project GreenHealth - Norte-01-0145-FEDER-000042. The authors would like to thank BPGV for the samples provided.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNascimento-Gonçalves, Elisabete; Ferreira, Teresa; Moutinho, Magda S.S.; Pires, Maria João; Bastos, Margarida M.S.M.; Medeiros, Rui; Nogueira, António José M.; Barros, Lillian; Ferreira, Isabel C.F.R.; Costa, Rui Miguel Gil; Oliveira, Paula A. (2021). Effect of hidroethanolic extract of Lavandula pedunculata (mill.) Cav. On morphometric parameters in HPV-16 trangenic mice. In Lillian Barros; Bruno Melgar Castañeda; Carlos Seiti Hurtado Shiraishi (Eds.) 1st Natural products application: Health, Cosmetic and Food: book of Abstracts. Bragançapt_PT
dc.identifier.isbn978-972-745-286-6
dc.identifier.urihttp://hdl.handle.net/10198/27148
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherInstituto Politécnico de Bragançapt_PT
dc.relationalterado para: “Contribuição para o estudo do cancro da próstata: influência do estilo de vida num modelo animal Contribution to the study of prostate cancer: lifestyle influence in an animal model”. Estudo do impacto da atividade física no microambiente do cancro da próstata num modelo animal
dc.relationCentre for the Research and Technology of Agro-Environmental and Biological Sciences
dc.relationMountain Research Center
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectLavandula penduculata (Mill.)pt_PT
dc.subjectResearch Subject Categories::TECHNOLOGY::Bioengineeringpt_PT
dc.titleEffect of hidroethanolic extract of Lavandula pedunculata (mill.) Cav. On morphometric parameters in HPV-16 trangenic micept_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitlealterado para: “Contribuição para o estudo do cancro da próstata: influência do estilo de vida num modelo animal Contribution to the study of prostate cancer: lifestyle influence in an animal model”. Estudo do impacto da atividade física no microambiente do cancro da próstata num modelo animal
oaire.awardTitleCentre for the Research and Technology of Agro-Environmental and Biological Sciences
oaire.awardTitleMountain Research Center
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBD%2F136747%2F2018/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04033%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.citation.conferencePlaceBragançapt_PT
oaire.citation.endPage122pt_PT
oaire.citation.startPage122pt_PT
oaire.citation.title1st Natural products application: Health, Cosmetic and Food: book of Abstractspt_PT
oaire.fundingStreamFARH
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameNogueira
person.familyNameBarros
person.familyNameFerreira
person.givenNameAntónio José M.
person.givenNameLillian
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifier144781
person.identifier.ciencia-id8A11-794E-36BD
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0001-8912-7355
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-3600-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id55865568268
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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