Advisor(s)
Abstract(s)
The buriti oil (Mauritia flexuosa L.) can be associated with polymeric matrices for biomedical
applications. This study aimed to evaluate the e ect of chitosan gel (CG) associated with buriti oil
(CGB) as a healing agent. The fatty acids and volatile compounds composition of buriti oil were
performed and the composite gels were characterized using FTIR and thermal analysis. Biological tests
including antimicrobial, antioxidant, anti-inflammatory and healing e ects were also investigated.
Buriti oil is composed of oleic and palmitic acids, and the main volatile compounds were identified.
The buriti oil did not show antimicrobial activity, on the other hand, the composite gel (chitosan
and oil) proved to be e cient against Staphylococcus aureus and Klebsiella pneumonia at the 10 mg/mL.
Similar behavior was observed for antioxidant activity, determined by the -carotene bleaching
assay, composite gels presenting higher activity and buriti oil showed anti-inflammatory activity,
which may be related to the inhibition of the release of free radicals. Regarding wound healing
performed using in vivo testing, the composite gel (CGB) was found to promote faster and complete
wound retraction. The results indicated that the gel chitosan–buriti oil has a set of properties that
improve its antibacterial, antioxidant and healing action, suggesting that this material can be used to
treat skin lesions.
Description
Keywords
Biological Healing Polysaccharides
Citation
Ferreira, Maria Onaira Gonçalves; Sá Lima, Idglan; Ribeiro, Alessandra Braga; Lobo, Anderson O.; Rizzo, Marcia S.; Osajima, Josy Anteveli; Estevinho, Leticia Miranda; Silva-Filho, Edson C. (2020). Biocompatible gels of chitosan-buriti oil for potential wound healing applications. Materials. ISSN 1996-1944. 13, p. 1-17