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Bioactive properties and functional constituents of Hypericum androsaemum L.: A focus on the phenolic profile

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dc.contributor.authorJabeur, Inès
dc.contributor.authorTobaldini, Flávia
dc.contributor.authorMartins, Natália
dc.contributor.authorBarros, Lillian
dc.contributor.authorMartins, Ivone
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorHenriques, Mariana
dc.contributor.authorSilva, Sónia
dc.contributor.authorAchour, Lotfi
dc.contributor.authorSantos-Buelga, Celestino
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2017-01-09T15:45:59Z
dc.date.available2017-01-09T15:45:59Z
dc.date.issued2016
dc.description.abstractHypericum androsaemum L. ethanol:water extract acted as a lipid peroxidation inhibitor and free radical scavenger. Amarked inhibition of the growth of breast, lung, cervical and hepatocellular human carcinoma cell lineswas also observed, whereas no toxicity was shown against non-tumor porcine liver cells (N400 μg/mL). The extract was also effective in inhibiting nitric oxide production, as an indicator of the anti-inflammatory potential. The anti-Candida effects varied among different strains of the same species, C. glabrata and C. tropicalis being the most sensible species with an effect directly related with the extract concentrations tested. A significant antibiofilm formation potential was also observed, namely for C. glabrata and C. tropicalis (biofilm reduction N90%). 5-O-Caffeoylquinic and 3-O-caffeoylquinic acids were themost abundant phenolic compounds identified in the extract, and might be related with the observed bioactive effects. Nevertheless, future studies should be carried out to obtain dose-response curves of the isolated active compounds, in order to perform further preclinically testing to quantify the presence of the most active compounds in the extract.pt_PT
dc.description.sponsorshipThe authors thank the Foundation for Science and Technology (FCT, Portugal) and FEDER under Programme PT2020 for financial support to CIMO (UID/AGR/00690/2013), LSRE (Project UID/EQU/50020/2013), N. Martins (SFRH/BD/87658/2012), S. Silva (SFRH/BPD/109053/2015) and L. Barros (SFRH/BPD/107855/2015) grants. The authors would also like to thank Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Conselho Nacional de Desenvolvimento Científico e Tecnológico (Cnpq), and Fundação Araucária for the financial support received. Flávia Tobaldini-Valerio, acknowledge the financial support of CAPES – Proc. 9469/14-1. The authors also thank FCT for the Strategic Project of the UID/BIO/04469/2013 unit, FCT and European Union funds (FEDER/COMPETE) for the project RECI/BBB-EBI/0179/2012 (FCOMP- 01-0124-FEDER-027462).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJabeur, Inés; Tobaldini, Flávia; Martins, Natália; Barros, Lillian; Martins, Ivone; Calhelha, Ricardo C.; Henriques, Mariana; Silva, Sónia; Achour, Lotfi; Santos-Buelga, Celestino; Ferreira, Isabel C.F.R. (2016). Bioactive properties and functional constituents of Hypericum androsaemum L.: A focus on the phenolic profile. Food Research International. ISSN 0963-9969. 89, p. 422-431pt_PT
dc.identifier.doi10.1016/j.foodres.2016.08.040pt_PT
dc.identifier.issn0963-9969
dc.identifier.urihttp://hdl.handle.net/10198/13696
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationPLANTAS MEDICINAIS A UTILIZAR EM FITOTERAPIA COMO ANTI-FÚNGICOS: EFEITO DE COMPOSTOS FENÓLICOS NO CRESCIMENTO DE ESPÉCIES DE CANDIDA EM SUSPENSÃO E EM BIOFILMES
dc.relationEffect of gastrointestinal microbiota in Candida species homeostasis and pathogenicity
dc.relationProviding industry and consumers with new alternative sources of natural additives from plant origin in the classes of preservatives and colouring agents: extraction, purification, stabilization and product development
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectHypericum androsaemum L.pt_PT
dc.subjectAntioxidant Cytotoxicpt_PT
dc.subjectAnti-inflammatorypt_PT
dc.subjectAnti-Candidapt_PT
dc.subjectPhenolic compoundspt_PT
dc.titleBioactive properties and functional constituents of Hypericum androsaemum L.: A focus on the phenolic profilept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitlePLANTAS MEDICINAIS A UTILIZAR EM FITOTERAPIA COMO ANTI-FÚNGICOS: EFEITO DE COMPOSTOS FENÓLICOS NO CRESCIMENTO DE ESPÉCIES DE CANDIDA EM SUSPENSÃO E EM BIOFILMES
oaire.awardTitleEffect of gastrointestinal microbiota in Candida species homeostasis and pathogenicity
oaire.awardTitleProviding industry and consumers with new alternative sources of natural additives from plant origin in the classes of preservatives and colouring agents: extraction, purification, stabilization and product development
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAGR%2F00690%2F2013/PT
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/RECI%2FBBB-EBI%2F0179%2F2012/PT
oaire.citation.endPage431pt_PT
oaire.citation.startPage422pt_PT
oaire.citation.titleFood Research Internationalpt_PT
oaire.citation.volume89pt_PT
oaire.fundingStream5876
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oaire.fundingStreamOE
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oaire.fundingStreamCOMPETE
person.familyNameJabeur
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person.familyNameFerreira
person.givenNameInès
person.givenNameLillian
person.givenNameRicardo C.
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person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-7485-3554
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-3600-2013
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project.funder.identifierhttp://doi.org/10.13039/501100001871
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rcaap.rightsopenAccesspt_PT
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