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Microbubble moving in blood flow in microchannels: effect on the cell-free layer and cell local concentration

2017Journal article Open access
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dc.contributor.authorBento, David
dc.contributor.authorSousa, Lúcia Isabel Teixeira
dc.contributor.authorYaginuma, Tomoko
dc.contributor.authorGarcia, Valdemar
dc.contributor.authorLima, Rui A.
dc.contributor.authorMiranda, João Mário
dc.date.accessioned2018-01-31T10:00:00Z
dc.date.accessioned2018-02-01T09:37:48Z
dc.date.available2018-01-31T10:00:00Z
dc.date.available2018-02-01T09:37:48Z
dc.date.issued2017
dc.description.abstractGas embolisms can hinder blood flow and lead to occlusion of the vessels and ischemia. Bubbles in microvessels circulate as tubular bubbles (Taylor bubbles) and can be trapped, blocking the normal flow of blood. To understand how Taylor bubbles flow in microcirculation, in particular, how bubbles disturb the blood flow at the scale of blood cells, experiments were performed in microchannels at a low Capillary number. Bubbles moving with a stream of in vitro blood were filmed with the help of a high-speed camera. Cell-free layers (CFLs) were observed downstream of the bubble, near the microchannel walls and along the centerline, and their thicknesses were quantified. Upstream to the bubble, the cell concentration is higher and CFLs are less clear. While just upstream of the bubble the maximum RBC concentration happens at positions closest to the wall, downstream the maximum is in an intermediate region between the centerline and the wall. Bubbles within microchannels promote complex spatio-temporal variations of the CFL thickness along the microchannel with significant relevance for local rheology and transport processes. The phenomenon is explained by the flow pattern characteristic of low Capillary number flows. Spatio-temporal variations of blood rheology may have an important role in bubble trapping and dislodging.en_EN
dc.description.sponsorshipThe authors acknowledge the financial support provided by PTDC/SAU-BEB/105650/2008, PTDC/SAU-ENB/116929/2010, EXPL/EMS-SIS/2215/2013 and PTDC/QEQ-FTT/4287/ 2014 from FCT (Science and Technology Foundation), COMPETE, QREN and European Union (FEDER).
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationBento, David; Sousa, Lúcia; Yaginuma, Tomoko; Garcia, Valdemar; Lima, Rui; Miranda, João M. (2017). Microbubble moving in blood flow in microchannels: effect on the cell-free layer and cell local concentration. Biomedical Microdevices. ISSN 1387-2176. 19:6en_EN
dc.identifier.doi10.1007/s10544-016-0138-zen_EN
dc.identifier.issn1387-2176
dc.identifier.urihttp://hdl.handle.net/10198/15385
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationBIOMIMETIC - A biomimetic microdevice for the diagnosis of erythrocytes diseases based on their deformability
dc.subjectCell-free layeren_EN
dc.subjectGas embolismen_EN
dc.subjectIn vitro blooden_EN
dc.subjectMicro bubbleen_EN
dc.subjectMicrofluidicsen_EN
dc.subjectRed blood cellsen_EN
dc.titleMicrobubble moving in blood flow in microchannels: effect on the cell-free layer and cell local concentrationen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleBIOMIMETIC - A biomimetic microdevice for the diagnosis of erythrocytes diseases based on their deformability
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FSAU-BEB%2F105650%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FSAU-ENB%2F116929%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/EXPL%2FEMS-SIS%2F2215%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/PEst-OE%2FLIN%2FUI0287%2F2014/PT
oaire.fundingStream5876-PPCDTI
oaire.fundingStream5876-PPCDTI
oaire.fundingStreamCOMPETE
oaire.fundingStream5876
person.familyNameGarcia
person.familyNameLima
person.givenNameValdemar
person.givenNameRui A.
person.identifier.ciencia-idEE12-C3FB-349D
person.identifier.orcid0000-0002-3941-2438
person.identifier.orcid0000-0003-3428-637X
person.identifier.ridH-5157-2016
person.identifier.scopus-author-id18437397800
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
relation.isAuthorOfPublicationf9422279-4412-49c2-becd-1e696a8c5c4b
relation.isAuthorOfPublication7b50c499-8095-4f4f-8b1b-fa7388e4ff62
relation.isAuthorOfPublication.latestForDiscovery7b50c499-8095-4f4f-8b1b-fa7388e4ff62
relation.isProjectOfPublication3897ce26-be5f-458d-829a-925628d3b9c7
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