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Roots and rhizomes of wild Asparagus: Nutritional composition, bioactivity and nanoencapsulation of the most potent extract

2021Journal article Open access
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dc.contributor.authorAdouni, Khawla
dc.contributor.authorJúlio, Ana Carolina
dc.contributor.authorSantos-Buelga, Celestino
dc.contributor.authorGonzález-Paramás, Ana María
dc.contributor.authorFilipe, Patrícia
dc.contributor.authorRijo, Patrícia
dc.contributor.authorLima, Sofia A. Costa
dc.contributor.authorReis, Salette
dc.contributor.authorFernandes, Ângela
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorFernández-Ruiz, Virginia
dc.contributor.authorMorales, Patricia
dc.contributor.authorFlamini, Guido
dc.contributor.authorAchour, Lotfi
dc.contributor.authorFonte, Pedro
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2021-11-22T14:36:37Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2021-11-22T14:36:37Z
dc.date.issued2021
dc.description.abstractThe nutritional composition and bioactive properties of roots and rhizomes of Asparagus stipularis were evaluated. Antioxidant activity of extracts obtained by infusion was evaluated using free radicals scavenging and reducing power methods. Porcine liver primary cell was used to check the hepatotoxicity of infusions. Results revealed that Asparagus samples are likely a source of nutrients, such as dietary fibre and essential fatty acids. HPLC-DAD-ESI/MS characterization of infusions allowed the identification and quantitation of 7 phenolic compounds, all hydroxycinnamoyl derivatives, with caffeic acid as the most abundant. Roots infusion contained the highest amounts of these compounds. It also exhibited the highest antioxidant activity in all assays, with EC50 values of 0.44 ± 0.01, 0.98 ± 0.03 and 0.64 ± 0.01 mg/mL for DPPH, ABTS and FRAP assays, respectively, with no toxicity towards PLP2 primary cell cultures (GI50 > 400 μg/mL). PLGA nanoparticles loaded with root extract were prepared using solvent-evaporation double emulsion method. Nanoparticles size was about 260 nm and a polydispersity index around 0.1, with a zeta potential of about -36 mV, as well as a good encapsulation efficiency of approximately 83%. Their morphology was analysed by SEM and spherical polymeric nanoparticles with a smooth surface were observed. FTIR and DSC were also performed, which allowed corroborating the efficacy of the encapsulation and to confirm the production of a stable and robust system to load Asparagus extracts. The developed nanoparticles are expected to be used as delivery systems for bioactive compounds of A. stipularis and they could be used as an innovative dietary supplement.en_EN
dc.description.sponsorshipThe UCM authors would like to thank to ALIMNOVA Research Group (UCM GR105/18) and Spanish Government through the project PID2019-109365RA-I00. Authors are also grateful to Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES to CIMO (UIDB/00690/2020), LAQV (UIDB/50006/2020), CCMar (UIDB/04326/2020), CBIOS (UIDB/ 04567/2020) and iBB-IST (UIDB/04565/2020). A. Fernandes contract was provided by National funding by FCT, P. I., through the institutional scientific employment program-contract. The authors are also grateful to FEDER-Interreg España-Portugal programme for financial support through the project 0377_Iberphenol_6_E. The GIP-USAL is financially supported by the Spanish Government through the project AGL2015- 64522-C2-2-R.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationAdouni, Khaoula; Júlio, Ana; Santos-Buelga, Celestino; González-Paramás, Ana M.; Filipe, Patrícia; Rijo, Patricia; Costa Lima, Sofia A.; Reis, Salette; Fernandes, Ângela; Ferreira, Isabel C.F.R.; Fernández-Ruiz, Virginia; Morales, Patricia; Flamini, Guido; Achour, Lotfi; Fonte, Pedro (2021). Roots and rhizomes of wild Asparagus: Nutritional composition, bioactivity and nanoencapsulation of the most potent extract. Food Bioscience. ISSN 2212-4292.en_EN
dc.identifier.doi10.1016/j.fbio.2021.101334en_EN
dc.identifier.issn2212-4292
dc.identifier.urihttp://hdl.handle.net/10198/24254
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationMountain Research Center
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationAlgarve Centre for Marine Sciences
dc.relationResearch Center for Biosciences & Health Technologies
dc.relationInstitute for Bioengineering and Biosciences
dc.subjectAntioxidant activityen_EN
dc.subjectAsparagus stipularisen_EN
dc.subjectNanoparticlesen_EN
dc.subjectNutritional compositionen_EN
dc.subjectPLGAen_EN
dc.titleRoots and rhizomes of wild Asparagus: Nutritional composition, bioactivity and nanoencapsulation of the most potent extracten_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleResearch Center for Biosciences & Health Technologies
oaire.awardTitleInstitute for Bioengineering and Biosciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04567%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04565%2F2020/PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameFernandes
person.familyNameFerreira
person.givenNameÂngela
person.givenNameIsabel C.F.R.
person.identifier144781
person.identifier.ciencia-id2015-0434-AE7C
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-0157-9873
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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