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Plants used in folk medicine: the potential of their hydromethanolic extracts against Candida species

2015Journal article Open access
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dc.contributor.authorMartins, Natália
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorBarros, Lillian
dc.contributor.authorCarvalho, Ana Maria
dc.contributor.authorHenriques, Mariana
dc.contributor.authorSilva, Sónia
dc.date.accessioned2015-10-19T10:07:20Z
dc.date.available2015-10-19T10:07:20Z
dc.date.issued2015
dc.description.abstractCurrently, opportunistic fungal infections are considered a serious problem regarding public health. Despite the advances towards the synthesis of new antifungal agents, an increasing incidence of drug-resistant microorganisms has been observed. In this sense, other alternatives are necessary. In the present work, the antifungal activity of extracts from ten different plants, commonly used in folk medicine, were evaluated against nineteen Candida strains, including C. albicans, C. glabrata, C. parapsilosis and C. tropicalis species. Although the majority of the extracts had no antimicrobial effect, Juglans regia extract was very effective, exerting an inhibitory effect against all the tested Candida strains, while Eucalyptus globulus was effective against seventeen of them. Pterospartum tridentatum and Rubus ulmifolius presented similar antifungal effects, being effective against six Candida strains. The diameter of halo ranged, respectively, between 9-14 mm and 9-21 mm to the mentioned plant extracts, and the MIC50 values evidenced mainly a fungistatic activity. Both extracts showed similar MIC50 values for C. albicans strains, while C. parapsilosis and C. glabrata were more sensible to E. globulus. Otherwise, all the C. tropicalis strains were more sensible to J. regia. Overall, hydromethanolic plant extracts could constitute promissory alternatives to the traditional antifungal agents.pt_PT
dc.description.sponsorshipThe authors are grateful to Foundation for Science and Technology (FCT, Portugal) for N. Martins grant (SFRH/BD/87658/2012), L. Barros researcher contract under “Programa Compromisso com Ciência – 2008” and financial support to the research centre CIMO (strategic project PEst-OE/AGR/UI0690/2011). This work was also supported by the Programa Operacional, Fatores de competitividade – COMPETE and by national funds through FCT – Fundação para a Ciência e a Tecnologia on the scope of the projects FCT PTDC/SAU-MIC/119069/2010, RECI/EBB-EBI/0179/2012 and PEst-OE/EQB/LA0023/2013. The authors thank the Project “BioHealth - Biotechnology and Bioengineering approaches to improve health quality", Ref. NORTE-07-0124-FEDER-000027, co-funded by the Programa Operacional Regional do Norte (ON.2 – O Novo Norte), QREN, FEDER. The authors are also grateful to “MaisErvas - Aromáticas e Medicinais” and “Américo Duarte Paixão Lda.” for the supplying of some plant species.pt_PT
dc.identifier10.1016/j.indcrop.2014.12.033
dc.identifier.citationMartins, Natália; Ferreira, Isabel C.F.R.; Barros, Lillian; Carvalho, Ana Maria; Henriques, Mariana; Silva, Sónia (2015). Plants used in folk medicine: the potential of their hydromethanolic extracts against Candida species. Industrial Crops and Products. ISSN 0926-6690. 66, p. 62-67
dc.identifier.doi10.1016/j.indcrop.2014.12.033
dc.identifier.urihttp://hdl.handle.net/10198/12157
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationPLANTAS MEDICINAIS A UTILIZAR EM FITOTERAPIA COMO ANTI-FÚNGICOS: EFEITO DE COMPOSTOS FENÓLICOS NO CRESCIMENTO DE ESPÉCIES DE CANDIDA EM SUSPENSÃO E EM BIOFILMES
dc.relationStrategic Project - UI 690 - 2011-2012
dc.relationMechanisms of Candida glabrata biofilms tolerance to antifungal agents
dc.relationConsolidating Research Expertise and Resources on Cellular and Molecular Biotechnology at CEB/IBB
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectMedicinal plantspt_PT
dc.subjectHydromethanolic extractspt_PT
dc.subjectAntifungal activitypt_PT
dc.subjectCandida speciespt_PT
dc.titlePlants used in folk medicine: the potential of their hydromethanolic extracts against Candida speciespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitlePLANTAS MEDICINAIS A UTILIZAR EM FITOTERAPIA COMO ANTI-FÚNGICOS: EFEITO DE COMPOSTOS FENÓLICOS NO CRESCIMENTO DE ESPÉCIES DE CANDIDA EM SUSPENSÃO E EM BIOFILMES
oaire.awardTitleStrategic Project - UI 690 - 2011-2012
oaire.awardTitleMechanisms of Candida glabrata biofilms tolerance to antifungal agents
oaire.awardTitleConsolidating Research Expertise and Resources on Cellular and Molecular Biotechnology at CEB/IBB
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F87658%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0690%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FSAU-MIC%2F119069%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/RECI%2FBBB-EBI%2F0179%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/Incentivo%2FEQB%2FLA0023%2F2013/PT
oaire.citation.endPage67pt_PT
oaire.citation.startPage62pt_PT
oaire.citation.titleIndustrial Crops and Productspt_PT
oaire.citation.volume66pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream5876-PPCDTI
oaire.fundingStream5876-PPCDTI
oaire.fundingStream3599-PPCDT
person.familyNameFerreira
person.familyNameBarros
person.familyNameCarvalho
person.givenNameIsabel C.F.R.
person.givenNameLillian
person.givenNameAna Maria
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person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-idD31A-35AF-E2A9
person.identifier.orcid0000-0003-4910-4882
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0001-5508-5935
person.identifier.ridE-8500-2013
person.identifier.ridJ-3600-2013
person.identifier.scopus-author-id36868826600
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id20336503900
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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