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Efficacy of Olive Leaf Extract in Improving Blood Pressure in Pre‐Hypertensive and Hypertensive Individuals: A Systematic Review and Meta‐Analysis

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datacite.subject.fosCiências Médicas::Medicina Clínica
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorLachovicz, Rebeca
dc.contributor.authorFerro-Lebres, Vera
dc.contributor.authorAlmeida-de-Souza, Juliana
dc.contributor.authorPereira, José Alberto
dc.date.accessioned2025-06-17T15:30:35Z
dc.date.available2025-06-17T15:30:35Z
dc.date.issued2025
dc.description.abstractAnnually, approximately 10 million deaths are attributed to hypertension, highlighting the critical need for effective treatments beyond conventional medications due to their limitations. Therefore, the aim of this study was to evaluate the impact of Olea europaea L. on blood pressure in adults with prehypertension and hypertension. The search, conducted from November/2022- October/2024 was performed on EBSCO, CABI, CNKI, Cochrane Library, DOAJ, PUBMED, SCOPUS, and WEB OF SCIENCE databases using Hypertension AND Olea europaea L. Eligible studies included those evaluating the effect of Olea europaea L. on systolic/diastolic blood pressure in hypertensive or pre-hypertensive adults. Exclusion criteria were multi-preparation interventions. Data on reference, country, sample, intervention/control details, duration, and differences in systolic and diastolic blood pressure, adverse effects, and medication use were extracted manually. The mean differences, heterogeneity (I2) and quality of the studies were assessed using Review Manager (version 5.4). From 211 found studies, 3 met the eligibility criteria, considering 248 participants analysed. An antihypertensive effect was observed on systolic and diastolic blood pressure in the pre- vs. post-intervention in the global analysis (systolic −6.03 mmHg, 95% CI: [−11.60, −0.46], I2 = 82%, p = 0.03; diastolic −2.38 mmHg, 95% CI: [−4.96, 0.20], I2 = 50%, p = 0.07) and in the sub-analysis that included the studies with the highest dose (1000 mg/day) (systolic−11.45 mmHg, 95% CI:[−13.99, −8.91], I2 = 0%, p ≤ 0.001; diastolic −4.65 mmHg, 95% CI: [−6.56, −2.74], I2 = 0%, p ≤ 0.001). Olive leaf extract (1000 mg/day) may reduce systolic and diastolic blood pressure by −11.45 and −4.65 mmHg, respectively. However, limitations include variable trial quality and exclusion of studies not written in English. Additional comprehensive clinical studies are essential to confirm its efficacy and safety.eng
dc.description.sponsorshipThis work was supported by national funds through Foundation for Science and Technology [in EN] or Fundação para a Ciência e a Tecnologia [in PT] (FCT), Ministry of Science, Technology and Higher Education (MCTES) Funded by national funds (PIDDAC): CIMO, UIDB/00690/2020 (DOI:10.54499/UIDB/00690/2020) and UIDP/00690/2020 (DOI: 10.54499/UIDP/00690/2020); and SusTEC, LA/P/0007/2020 (DOI: 10.54499/LA/P/0007/2020).
dc.identifier.citationLachovicz, Rebeca; Ferro-Lebres, Vera; Almeida-de-Souza, Juliana; Pereira, José Alberto.(2025). Efficacy of Olive Leaf Extract in Improving Blood Pressure in Pre‐Hypertensive and Hypertensive Individuals: A Systematic Review and Meta‐Analysis. Phytotherapy Research. ISSN 0951-418X. p. 1-12
dc.identifier.doi10.1002/ptr.8509
dc.identifier.eissn1099-1573
dc.identifier.issn0951-418X
dc.identifier.urihttp://hdl.handle.net/10198/34608
dc.language.isoeng
dc.peerreviewedyes
dc.publisherWiley
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.relationAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
dc.relation.ispartofPhytotherapy Research
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBlood pressure
dc.subjectOlea europaea L.
dc.subjectOleuropein
dc.subjectPhytotherapy
dc.subjectPre-hypertension
dc.titleEfficacy of Olive Leaf Extract in Improving Blood Pressure in Pre‐Hypertensive and Hypertensive Individuals: A Systematic Review and Meta‐Analysiseng
dc.typereview
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardTitleAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0007%2F2020/PT
oaire.citation.endPage12
oaire.citation.startPage1
oaire.citation.titlePhytotherapy Research
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameLachovicz
person.familyNameFerro-Lebres
person.familyNameAlmeida-de-Souza
person.familyNamePereira
person.givenNameRebeca
person.givenNameVera
person.givenNameJuliana
person.givenNameJosé Alberto
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person.identifier.ciencia-idFA14-073E-C116
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person.identifier.orcid0000-0003-3691-9791
person.identifier.orcid0000-0002-3782-9264
person.identifier.orcid0000-0002-2578-3684
person.identifier.orcid0000-0002-2260-0600
person.identifier.ridL-6798-2014
person.identifier.scopus-author-id57194551953
person.identifier.scopus-author-id57204366348
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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