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Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid

2013Journal article Open access
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dc.contributor.authorStojković, Dejan
dc.contributor.authorDavidović, Slobodan
dc.contributor.authorŽivković, Jelena
dc.contributor.authorGlamočlija, Jasmina
dc.contributor.authorĆirić, Ana
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorSoković, Marina
dc.date.accessioned2014-09-24T16:50:48Z
dc.date.available2014-09-24T16:50:48Z
dc.date.issued2013
dc.description.abstractMorchella esculenta (L.) Pers. methanolic extracts, obtained from fruiting bodies growing wild in Serbia and Portugal, were screened for their antimutagenic properties and compared to protocatechuic acid, previously identified in both species. Salmonella typhimurium TA100 reversion assay was used for the antimutagenic properties. Methanolic extracts expressed important antimutagenic potency towards S. typhimurium, which was documented by index of antimutagenicity (I). Sample from Serbia expressed slightly higher antimutagenic properties with inhibition rate of 58.7%. Sample from Portugal gave inhibition rate of 51.7%. Protocatechuic acid had inhibition rate I of his+ revertants of 72.4%. Cell viability in the presence of extracts was also documented. M. esculenta samples from Serbia and Portugal possessed novel biological potential for the studied species, as well as its phenolic compound – protocatechuic acid, identified in both samples. Genotoxic effect, regarding mitotic index and chromosomal aberration score, was also assessed by using Allium cepa L. assay. Protocatechuic acid showed the most significant decrease in mitotic index, as well as decrease in chromosomal aberration score.por
dc.description.sponsorshipSerbian Ministry of Education, Science and Technological Development; FCT Portugal; COMPETE/QREN/EU, PTDC/AGR-ALI/110062/2009 PEst-OE/AGR/UI0690/2011por
dc.identifier.citationStojković, Dejan; Davidović, Slobodan; Živković, Jelena; Glamočlija, Jasmina; Ćirić, Ana; Ferreira, Isabel C.F.R.; Soković, Marina (2013). Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid. Frontiers in Life Science. ISSN 2155-3769. 7:3-4, p. 218-223por
dc.identifier.doi10.1080/21553769.2014.901925
dc.identifier.issn2155-3769
dc.identifier.urihttp://hdl.handle.net/10198/10581
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherTaylor&Francis Ltdpor
dc.relationPortuguese Wild Mushrooms: Chemical characterization and functional study of antiproliferative and proapoptotic properties in cancer cell lines
dc.relationStrategic Project - UI 690 - 2011-2012
dc.subjectAllium cepa assaypor
dc.subjectAntimitoticpor
dc.subjectAntimutagenicpor
dc.subjectAmes testpor
dc.subjectMorchella esculentapor
dc.subjectProtocatechuic acidpor
dc.titleComparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acidpor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitlePortuguese Wild Mushrooms: Chemical characterization and functional study of antiproliferative and proapoptotic properties in cancer cell lines
oaire.awardTitleStrategic Project - UI 690 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FAGR-ALI%2F110062%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0690%2F2011/PT
oaire.citation.endPage223por
oaire.citation.issue3-4por
oaire.citation.startPage218por
oaire.citation.titleFrontiers in Life Sciencepor
oaire.citation.volume7por
oaire.fundingStream5876-PPCDTI
oaire.fundingStream6817 - DCRRNI ID
person.familyNameFerreira
person.givenNameIsabel C.F.R.
person.identifier144781
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typearticlepor
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relation.isAuthorOfPublication.latestForDiscoverybd0d1537-2e03-41fb-b27a-140af9c35db8
relation.isProjectOfPublication59db4b60-8cc2-4f07-a25a-8cfe78f2778f
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