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Phenolic profile obtained by HPLC-DAD-ESI/MS and in vitro bioactivities of Equisetum giganteum L. and Tilia platyphyllos Scop.

2017Conference object Open access
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dc.contributor.authorJabeur, Inès
dc.contributor.authorMartins, Natália
dc.contributor.authorBarros, Lillian
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorVaz, Josiana A.
dc.contributor.authorAchour, Lotfi
dc.contributor.authorSantos-Buelga, Celestino
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2017-12-21T10:55:05Z
dc.date.available2017-12-21T10:55:05Z
dc.date.issued2017
dc.description.abstractMedicinal plants are a source of a wide range of bioactive compounds, such as alkaloids, terpenes, steroids and phenolic compounds, which are responsible for multiple biological effects [1, 2]. In the present work, the phenolic composition and bioactive potential of the aqueous and hydroethanolic extracts of Equisetum giganteum L. and Tilia platyphyllos Scop. were evaluated. The phenolic compounds were determined using a Hewlett-Packard 1100 chromatograph, with a diode array detector coupled to a MS detector API 3200 Qtrap through an ESI source and a triple quadrupole-ion trap mass analyser, while the bioactive properties were evaluated in terms of antioxidant, anti-inflammatory, and cytotoxic activities. The hydroethanolic extracts revealed higher amounts of phenolic compounds than infusions, being the concentration of flavonoids (81% of the phenolic composition) remarkably higher than the phenolic acids content (19%), in both species and extracts. T. platyphyllos presented a higher phenolic content (50.4 ± 0.4 mg/g of hydroethanolic extract and 11.65 ± 0.05 mg/g of lyophilized infusion), than E. giganteum (21.7 ± 0.4 mg/g and 4.98 ± 0.03 mg/g, respectively). Moreover, kaempferol- O-glucoside-O-rutinoside was the most abundant flavonoid in E. giganteum extract, while protocatechuic acid and (−)-epicatechin were the most abundant phenolic acid and flavonoid, respectively, in T. platyphyllos extract. Regarding the bioactive assays, both extracts obtained from T. platyphyllos showed the highest potential and none of the extracts showed toxicity in non-tumor liver cells. These biological properties were highly correlated with its content and composition in phenolic compounds. Thus, it would be interesting to evaluate the in vivo efficacy of both plant extracts to unveil the involved modes of action and to establish effective therapeutic doses.pt_PT
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology (FCT, Portugal) and FEDER under Programme PT2020 for financial support to CIMO (UID/AGR/00690/2013) and L. Barros contract; to the Interreg España-Portugal for financial support through the project 0377_Iberphenol_6_E.pt_PT
dc.identifier.citationJabeur, Inés; Martins, Natália; Barros, Lillian; Calhelha, Ricardo C.; Vaz, Josiana; Achour, Lotfi; Santos-Buelga, Celestino; Ferreira, Isabel C.F.R. (2017). Phenolic profile obtained by HPLC-DAD-ESI/MS and in vitro bioactivities of Equisetum giganteum L. and Tilia platyphyllos Scop. In 10º Encontro Nacional de Cromatografia: livro de resumos. Bragança. ISBN 978-972-745-234-7pt_PT
dc.identifier.isbn978-972-745-234-7
dc.identifier.urihttp://hdl.handle.net/10198/14807
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titlePhenolic profile obtained by HPLC-DAD-ESI/MS and in vitro bioactivities of Equisetum giganteum L. and Tilia platyphyllos Scop.pt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAGR%2F00690%2F2013/PT
oaire.citation.conferencePlaceBragança, Portugalpt_PT
oaire.citation.title10º Encontro Nacional de Cromatografiapt_PT
oaire.fundingStream5876
person.familyNameJabeur
person.familyNameBarros
person.familyNameCalhelha
person.familyNameVaz
person.familyNameFerreira
person.givenNameInès
person.givenNameLillian
person.givenNameRicardo C.
person.givenNameJosiana A.
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifier144781
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-id171B-88BA-64F5
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-7485-3554
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0002-6989-1169
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-3600-2013
person.identifier.ridJ-2172-2014
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id16305323200
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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