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Visualization and measurement of red blood cells flowing in microfluidic devices

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dc.contributor.authorRodrigues, Raquel Oliveira
dc.contributor.authorPinho, Diana
dc.contributor.authorFaustino, Vera
dc.contributor.authorYaginuma, Tomoko
dc.contributor.authorBento, David
dc.contributor.authorFernandes, Carla S.
dc.contributor.authorGarcia, Valdemar
dc.contributor.authorLima, Rui A.
dc.date.accessioned2014-07-31T10:29:46Z
dc.date.available2014-07-31T10:29:46Z
dc.date.issued2014
dc.description.abstractSeveral experimental techniques were performed in the past years using in vitro environments, in an attempt to not only understand the blood flow behaviour in microcirculation but also develop microfluidic devices as an alternative clinical methodology to detect blood diseases. Hence, the visualization and measurement of red blood cells (RBCs) flowing in a microfluidic device are important to provide not only essential information about hydrodynamic characteristics of the blood but also vital information to diagnose the initial symptoms of diseases during clinical investigations. For instance, RBC rigidity has been correlated with myocardial infarction, diabetes mellitus, hypertension, and also other haematological disorders and diseases that affect RBC deformation more directly, such as, hereditary spherocytosis, sickle cell anaemia and malaria. Regarding a better understanding of the RBCs deformation and motion, we present in this paper a compilation of studies made in our research group, using several microfluidic devices with different microchannel geometries and fabrication techniques (i.e., soft-lithography, xurography and hybrids) that focus in the shear and extensional flow behaviour, either in healthy or chemically stiffed RBCs.por
dc.description.sponsorshipThe authors acknowledge the financial support provided by 2007 Global COE Program “Global Nano-Biomedical Engineering Education and Research Network”, Japan and grant-in-Aid for Science and Technology, PTDC/SAU-BEB/105650/2008, PTDC/EME-MFE/099109/2008, PTDC/SAUENB/116929/2010, EXPL/EMS-SIS/2215/2013, scholarship SFRH/BD/91192/2012 and scholarship SFRH/BD/89077/2012 from FCT (Science and Technology Foundation), COMPETE, QREN and European Union (FEDER). The authors are also very grateful to Dr. Mónica Oliveira (Strathclyde University), Professor Takuji Ishikawa and Professor Takami Yamaguchi (Tohoku University) for their suggestions and support to this research work.
dc.identifier.citationRodrigues, Raquel; Pinho, Diana; Faustino, Vera; Yaginuma, T.; Bento, David; Fernandes, Carla S.; Garcia, Valdemar; Lima, R. (2014). Visualization and measurement of red blood cells flowing in microfluidic device. In 7th World Congress of Biomechanics. Bostonpor
dc.identifier.urihttp://hdl.handle.net/10198/9992
dc.language.isoengpor
dc.peerreviewedyespor
dc.relationANEURYSM - Hemodynamic Study in Cerebral Aneurysms
dc.relationBIOMIMETIC - A biomimetic microdevice for the diagnosis of erythrocytes diseases based on their deformability
dc.subjectRed blood cells deformationpor
dc.subjectMicrofluidic devicespor
dc.titleVisualization and measurement of red blood cells flowing in microfluidic devicespor
dc.typeconference object
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oaire.awardTitleANEURYSM - Hemodynamic Study in Cerebral Aneurysms
oaire.awardTitleBIOMIMETIC - A biomimetic microdevice for the diagnosis of erythrocytes diseases based on their deformability
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FSAU-BEB%2F105650%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FEME-MFE%2F099109%2F2008/PT
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F89077%2F2012/PT
oaire.citation.conferencePlaceBostonpor
oaire.citation.title7th World Congress of Biomechanicspor
oaire.fundingStream5876-PPCDTI
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person.familyNamePinho
person.familyNameFernandes
person.familyNameGarcia
person.familyNameLima
person.givenNameDiana
person.givenNameCarla S.
person.givenNameValdemar
person.givenNameRui A.
person.identifier.ciencia-id5214-ED0C-35E8
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person.identifier.ciencia-idEE12-C3FB-349D
person.identifier.orcid0000-0002-3884-6496
person.identifier.orcid0000-0002-3138-7493
person.identifier.orcid0000-0002-3941-2438
person.identifier.orcid0000-0003-3428-637X
person.identifier.ridA-4269-2015
person.identifier.ridH-5157-2016
person.identifier.scopus-author-id8253740700
person.identifier.scopus-author-id18437397800
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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