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Authenticity and Bioactive Markers Search in the Phenolic‐Rich Extracts of Asteraceae Medicinal Plants Through Integrative Computational Chemometrics

2025Artigo científico Acesso aberto
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dc.contributor.authorGarcia Perez, Pascual
dc.contributor.authorGarcia‐Oliveira, Paula
dc.contributor.authorFinimundy, Tiane C.
dc.contributor.authorPinela, José
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorNenadić, Marija
dc.contributor.authorSoković, Marina
dc.contributor.authorSimal‐Gandara, Jesus
dc.contributor.authorBarros, Lillian
dc.contributor.authorPrieto Lage, Miguel A.
dc.date.accessioned2025-01-30T11:46:16Z
dc.date.available2025-01-30T11:46:16Z
dc.date.issued2025
dc.description.abstractThe Asteraceae family has been of significant concern for ethnobotanical studies, thanks to its health-promoting properties linked to a plethora of bioactive compounds, among which phenolic compounds play a critical role. In this work, a workflow based on computational chemometrics was employed to assess the authenticity and biomarker search of five key Asteraceae species commonly employed in traditional medicine. The UHPLC-DAD- ESI/ MS–MS phenolic profile of Asteraceae extracts was combined with the evaluation of several in vitro biological properties. Caffeoylquinic acids (CQAs), chicoric acids, and flavonoid glycosides were reported as authenticity markers of Achillea millefolium, Taraxacum officinale, and Arnica montana, respectively. The integration of phenolic profile and in vitro bioactivities provide insights for the identification of trans 3,5-O- dicaffeoylquinic acid (3,5-O- diCQA) and isorhamnetin glycosides as the major antioxidant agents in Asteraceae extracts, whereas several CQAs and caffeoyl-deoxy- octulopyranosonic acids have been reported as responsible for their cytotoxic and anti-inflammatory activities. These results shed light on the authentication and quality evaluation of Asteraceae extracts, along with the characterization of their functional properties, leading to their application in the design of novel plant-based functional foods.pt_PT
dc.description.sponsorshipPascual García-Pérez thanks the finantial support through the Ramón y Cajal program (reference: RYC2023-044123-I) by the Spanish Ministry of Science, Innovation and Universities, the National Research Agency (MCIU/AEI/10.13039/501100011033) and the European Social Fund Plus (FSE+). This work was also supported by national funds through FCT/MCTES (PIDDAC): CIMO, UIDB/00690/2020 (DOI: 10.54499/UIDB/00690/2020) and UIDP/00690/2020 (DOI: 10.54499/UIDP/00690/2020); and SusTEC, LA/P/0007/2020 (DOI: 10.54499/LA/P/0007/2020). L. Barros (DOI: 10.54499/CEECINST/00107/2021/CP2793/CT0002) and R. Calhelha (DOI: 10.54499/CEECINST/00016/2018/CP1505/CT0009) thanks FCT through the institutional scientific employment program–contract for their contract. Funding for open access charges: Universidade de Vigo/CRUE-CISUG.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGarcia‐Perez, Pascual; Garcia‐Oliveira, Paula; Finimundy, Tiane C.; Pinela, Jose; Calhelha, Ricardo C.; Nenadić, Marija; Soković, Marina; Simal‐Gandara, Jesus; Barros, Lillian; Prieto, Miguel A. (2025). Authenticity and Bioactive Markers Search in the Phenolic‐Rich Extracts of Asteraceae Medicinal Plants Through Integrative Computational Chemometrics. Food Science & Nutrition. ISSN 2048-7177. 13:1, p. 1-19pt_PT
dc.identifier.doi10.1002/fsn3.4720pt_PT
dc.identifier.issn2048-7177
dc.identifier.urihttp://hdl.handle.net/10198/31101
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.relationAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
dc.relationNot Available
dc.relationNot Available
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAntioxidantspt_PT
dc.subjectFunctional analysispt_PT
dc.subjectMultivariate statisticspt_PT
dc.subjectNutraceuticalspt_PT
dc.subjectRegularized canonical component analysispt_PT
dc.titleAuthenticity and Bioactive Markers Search in the Phenolic‐Rich Extracts of Asteraceae Medicinal Plants Through Integrative Computational Chemometricspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardTitleAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
oaire.awardTitleNot Available
oaire.awardTitleNot Available
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0007%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC INST 2018/CEECINST%2F00016%2F2018%2FCP1505%2FCT0009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC INST 2018/CEECINST%2F00016%2F2018%2FCP1505%2FCT0001/PT
oaire.citation.endPage19pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleFood Science & Nutritionpt_PT
oaire.citation.volume13pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamCEEC INST 2018
oaire.fundingStreamCEEC INST 2018
person.familyNameFinimundy
person.familyNamePinela
person.familyNameCalhelha
person.familyNameBarros
person.givenNameTiane C.
person.givenNameJosé
person.givenNameRicardo C.
person.givenNameLillian
person.identifier469085
person.identifier.ciencia-id2F18-67B1-776A
person.identifier.ciencia-id771C-2B43-B108
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-id9616-35CB-D001
person.identifier.orcid0000-0003-3516-0795
person.identifier.orcid0000-0001-7523-1637
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridB-4466-2014
person.identifier.ridJ-2172-2014
person.identifier.ridJ-3600-2013
person.identifier.scopus-author-id54392272800
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id35236343600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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