Repository logo
 
Publication

Inhibition of NF-kB activation and cytokines production in THP-1 monocytes by 2-styrylchromones

2015Journal article Open access
Simple item page
dc.contributor.authorGomes, Ana Sara
dc.contributor.authorCapela, João Paulo
dc.contributor.authorRibeiro, Daniela
dc.contributor.authorFreitas, Marisa
dc.contributor.authorSilva, Artur
dc.contributor.authorPinto, Diana
dc.contributor.authorSantos, Clementina M.M.
dc.contributor.authorCavaleiro, José
dc.contributor.authorLima, José L.F.C.
dc.contributor.authorFernandes, Eduarda
dc.date.accessioned2016-05-31T16:06:35Z
dc.date.available2016-05-31T16:06:35Z
dc.date.issued2015
dc.description.abstractNuclear factor kappa B (NF-kB) is one of the most important transcription factors whose modulation triggers a cascade of signaling events, namely the expression of many cytokines, enzymes, chemokines, and adhesion molecules, some of which being potential key targets for intervention in the treatment of inflammatory conditions. The 2-styrylchromones (2-SC) designation represents a well-recognized group of natural and synthetic chromones, vinylogues of flavones (2-phenylchromones). Several 2-SC were recently tested for their anti-inflammatory potential, regarding the arachidonic acid metabolic cascade, showing some motivating results. In addition, several flavones with structural similarities to 2-SC have shown NF-kB inhibitory properties. Hence, the aim of the present work was to continue the investigation on the interference of 2-SC in inflammatory pathways. Herein we report their effects on lipopolysaccharide (LPS)-induced NF-kB activation and consequent production of proinflammatory cytokines/chemokine, using a human monocytic cell line (THP-1). From the twelve 2-SC tested, three of them were able to significantly inhibit the NF-kB activation and to reduce the production of the proinflammatory cytokines/chemokine. The compound 3',4',5-trihydroxy-2- styrylchromone stood up as the most active in both assays, being a promising candidate for an anti-inflammatory drug.pt_PT
dc.identifier.citationGomes, Ana; Capela, João P.; Ribeiro, Daniela; Freitas, Marisa; Silva, Artur; Pinto, Diana; Santos, Clementina M.M.; Cavaleiro, José; Lima, José L.F.C.; Fernandes, Eduarda (2015). Inhibition of NF-kB activation and cytokines production in THP-1 monocytes by 2-styrylchromones. Medicinal Chemistry. ISSN 1573-4064. 11:6, p. 560-566pt_PT
dc.identifier.doi10.2174/1573406411666150209114702
dc.identifier.issn1573-4064
dc.identifier.urihttp://hdl.handle.net/10198/12951
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationFLAVONOIDS WITH POTENTIAL ANTI-INFLAMMATORY ACTIVITY: IN VITRO STRUCTURE/ACTIVITY STUDIES OF THEIR EFFECTS IN PRO-INFLAMMATORY SIGNALLING SYSTEMS
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectInflammationpt_PT
dc.subjectNuclear factor-kBpt_PT
dc.subjectPro-inflammatory cytokinespt_PT
dc.subjectStyrylchromonespt_PT
dc.subjectTHP-1 monocytespt_PT
dc.titleInhibition of NF-kB activation and cytokines production in THP-1 monocytes by 2-styrylchromonespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleFLAVONOIDS WITH POTENTIAL ANTI-INFLAMMATORY ACTIVITY: IN VITRO STRUCTURE/ACTIVITY STUDIES OF THEIR EFFECTS IN PRO-INFLAMMATORY SIGNALLING SYSTEMS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POCI/POCI%2FQUI%2F59284%2F2004/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F76909%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F72966%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F23299%2F2005/PT
oaire.citation.endPage566pt_PT
oaire.citation.startPage560pt_PT
oaire.citation.titleMedicinal Chemistrypt_PT
oaire.citation.volume11pt_PT
oaire.fundingStreamPOCI
oaire.fundingStreamSFRH
oaire.fundingStreamSFRH
person.familyNameSantos
person.givenNameClementina M.M.
person.identifier.ciencia-id9018-DB9C-C590
person.identifier.orcid0000-0003-4380-7990
person.identifier.scopus-author-id7201458663
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication64f662b6-775d-4ea0-bfd7-f527af0ac1a0
relation.isAuthorOfPublication.latestForDiscovery64f662b6-775d-4ea0-bfd7-f527af0ac1a0
relation.isProjectOfPublication1a77f25c-e459-4679-93cb-48bc8c6709ac
relation.isProjectOfPublicationfb950b82-915e-48c2-9614-16afcf9ab4c8
relation.isProjectOfPublication9d6c5adb-79a9-433f-8d3a-9646a126502e
relation.isProjectOfPublicationeaf94df2-b7be-4ace-b247-b5e141d427aa
relation.isProjectOfPublication.latestForDiscoveryeaf94df2-b7be-4ace-b247-b5e141d427aa

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
2015 Med Chem 11, 560.pdf
Size:
210.42 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.75 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

CIMO - Artigos em Revistas Indexados à WoS/Scopus