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Bioactive properties and phenolic profile of Momordica charantia L. medicinal plant growing wild in Trinidad and Tobago

2017Journal article Open access
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dc.contributor.authorSvobodova, Blanka
dc.contributor.authorBarros, Lillian
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorHeleno, Sandrina A.
dc.contributor.authorAlves, Maria José
dc.contributor.authorWalcott, Simone
dc.contributor.authorBittova, Miroslava
dc.contributor.authorKuban, Vlastimil
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2018-01-25T10:00:00Z
dc.date.accessioned2018-01-30T15:00:03Z
dc.date.available2018-01-25T10:00:00Z
dc.date.available2018-01-30T15:00:03Z
dc.date.issued2017
dc.description.abstractA wild variety of bitter melon Momordica charantia L. (Cucurbitaceae) has been used in bush medicine of Trinidad and Tobago for treatment of diabetes, inflammations and cancer. Despite many studies regarding the cultivated bitter melon, the wild variety has been poorly investigated. This study evaluates the biological activities of the ethanol/water extract of aerial parts and correlates these activities with the presence of phenolic compounds. The extract exhibited antioxidant activity in the four assays (DPPH, reducing power, ß-carotene bleaching and TBARS). The key role of oxidative stress in inflammation and tumorigenesis was supported by the results of anti-inflammatory (inhibition of nitric oxide production) and cytotoxicity (human tumor cell lines, namely HeLa, HepG2, MCF-7, and NCI-H460) assays. In contrast, no toxicity was observed in non-tumor cells. In the antibacterial screening, clinical resistant isolates were significantly affected (MIC 50 = 10–0.625 µg/mL), being Listeria monocytogenes the most susceptible. Three phenolic acids and eleven flavonol glycosides derivatives were identified, quercetin-3-O-pentosylhexoside being the most abundant.pt_PT
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology (FCT, Portugal) and FEDER under Programme PT2020 for financial support to CIMO (UID/AGR/00690/2013), LSRE (Project UID/EQU/50020/2013), L. Barros (SFRH/BPD/107855/2015), S. Heleno (SFRH/BPD/101413/2014) and R.C. Calhelha (SFRH/BPD/BPD/68344/2010) grants. This study was financially supported by Internal Grant Agency of Tomas Bata University in Zlin, project Nr. IGA/FT/2016/003.
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSvobodova, Blanka; Barros, Lillian; Calhelha, Ricardo C.; Heleno, Sandrina; Alves, Maria Jose; Walcott, Simone; Bittova, Miroslava; Kuban, Vlastimil; Ferreira, Isabel C.F.R. (2017). Bioactive properties and phenolic profile of Momordica charantia L. medicinal plant growing wild in Trinidad and Tobago. Industrial Crops and Products. ISSN 0926-6690. 95, p. 365-373en_EN
dc.identifier.doi10.1016/j.indcrop.2016.10.046pt_PT
dc.identifier.issn0926-6690
dc.identifier.urihttp://hdl.handle.net/10198/15266
dc.language.isoeng
dc.peerreviewedyespt_PT
dc.relationProviding industry and consumers with new alternative sources of natural additives from plant origin in the classes of preservatives and colouring agents: extraction, purification, stabilization and product development
dc.relationObtaining of mycosterols to develop new functionalized foods: extraction, refinement, stabilization and incorporation into dairy products
dc.subjectAnti-inflammatoryen_EN
dc.subjectAntimicrobial activityen_EN
dc.subjectAntioxidanten_EN
dc.subjectCytotoxicityen_EN
dc.subjectMomordica charantia L.en_EN
dc.subjectPhenolic compoundsen_EN
dc.titleBioactive properties and phenolic profile of Momordica charantia L. medicinal plant growing wild in Trinidad and Tobagoen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleProviding industry and consumers with new alternative sources of natural additives from plant origin in the classes of preservatives and colouring agents: extraction, purification, stabilization and product development
oaire.awardTitleObtaining of mycosterols to develop new functionalized foods: extraction, refinement, stabilization and incorporation into dairy products
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F107855%2F2015/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAGR%2F00690%2F2013/PT
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oaire.fundingStream5876
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person.familyNameBarros
person.familyNameCalhelha
person.familyNameHeleno
person.familyNameAlves
person.familyNameFerreira
person.givenNameLillian
person.givenNameRicardo C.
person.givenNameSandrina A.
person.givenNameMaria José
person.givenNameIsabel C.F.R.
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person.identifier.orcid0000-0002-9050-5189
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person.identifier.orcid0000-0001-7224-1098
person.identifier.orcid0000-0001-8506-4393
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-3600-2013
person.identifier.ridJ-2172-2014
person.identifier.ridL-5951-2014
person.identifier.ridM-6624-2016
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id6507978333
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project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticlept_PT
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