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Preserved organ function and redox homeostasis following repeated oral exposure to Quercus suber acorn shell extract in female FVB/n mice

2026Artigo científico Acesso aberto
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datacite.subject.fosCiências Naturais::Ciências Biológicas
datacite.subject.fosEngenharia e Tecnologia::Engenharia Química
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
datacite.subject.sdg04:Educação de Qualidade
datacite.subject.sdg15:Proteger a Vida Terrestre
dc.contributor.authorCorreia, Pedro
dc.contributor.authorMateus, Cristiano
dc.contributor.authorPinto, João Pedro
dc.contributor.authorAzevedo, Tiago
dc.contributor.authorFinimundy, Tiane C.
dc.contributor.authorBabo, Pedro
dc.contributor.authorNascimento-Gonçalves, Elisabete
dc.contributor.authorMedeiros, Catarina
dc.contributor.authorFélix, Luís
dc.contributor.authorSeixas, Fernanda
dc.contributor.authorBarros, Lillian
dc.contributor.authorOliveira, Paula A.
dc.date.accessioned2026-06-24T11:03:22Z
dc.date.available2026-06-24T11:03:22Z
dc.date.issued2026
dc.description.abstractAcorn shells (AS), a by-product of Quercus suber acorn processing, are rich in phenolic compounds with recognized bioactivities. However, their incorporation into food or nutraceutical formulations requires in vivo safety assessment under physiologically relevant exposure conditions. This study evaluated the effects of a hydroethanolic AS extract following repeated oral intake in female FVB/n mice over 25 days. The extract's phenolic profile was characterized by HPLC-DAD-ESI-MS/ MS. Nineteen animals (8-12 weeks old) were randomly assigned to four groups receiving drinking water containing 0, 100, 200 and 500 mu g/mL of extract. Animal welfare, food and water intake, and body weight were monitored throughout the study. At the end, animals were euthanized via anesthetic overdose, after which blood was collected for biochemical analysis, organs were weighed, and liver and kidney processed for histology and oxidative stress analysis. The extract was dominated by phenolic acids and hydrolysable tannins, primarily gallic/ellagic acid derivatives. No toxicity signs or mortality were recorded, and food and water intake remained similar across groups. Body weight and food and water intakes were unaffected, whereas an increase in liver, spleen, and left kidney relative weight was observed in the 200 mu g/mL dose (p < 0.05). Biochemical parameters were also preserved between groups, though the 200 mu g/mL group showed reduced renal lipid peroxidation (p < 0.05). Histological examination revealed no treatment-related hepatic or renal lesions. Overall, these findings indicate that repeated oral exposure to AS extract does not compromise systemic homeostasis under the tested conditions.eng
dc.description.sponsorshipThis work received financial support from PRIMA/0005/2022 within the scope of the MEDACORNET project – Rescuing acorns as a Mediterranean traditional superfood. Additional support was provided by national funds through the Portuguese Foundation for Science and Technology (FCT): UID/04033/2025 (10.54499/UID/04033/2025), Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), and LA/P/0126/2020 (10.54499/LA/P/0126/2020), Institute for Innovation, Capacity Building and Sustainability of Agri-Food Production (Inov4Agro). Funding was also provided by FCT to CIMO through UID/00690/2025 (10.54499/UID/00690/2025) and UID/PRR/00690/2025 (10.54499/UID/PRR/00690/2025), to SusTEC through LA/P/0007/2020 (10.54499/LA/P/0007/2020), to CECAV through UIDB/00772/2020 (10.54499/UIDB/00772/2020) and UID/00772/2025 (10.54499/UID/00772/2025), and to AL4AnimalS through LA/P/0059/2020 (10.54499/LA/P/0059/2020). National funding from FCT also supported the doctoral grant of T.A. (2023.01329.BD) and the Institutional Scientific Employment Program for L.F. (2021.00458.CEECIND/CP1690/CT0001) and L.B. (CEECINST/00107/2021/CP2793/CT0002). E.N.-G. and C.M. acknowledge PRR and European Funds NextGeneration EU for their fellowship grants (BI/UTAD/41/2025 and BI/UTAD/17/2025).
dc.identifier.citationCorreia, Pedro; Mateus, Cristiano; Pinto, Joao Pedro; Azevedo, Tiago; Finimundy, Tiane; Babo, Pedro; Nascimento-Goncalves, Elisabete; Medeiros, Catarina; Felix, Luis; Seixas, Fernanda; Barros, Lillian; Oliveira, Paula A. (2026). Preserved organ function and redox homeostasis following repeated oral exposure to Quercus suber acorn shell extract in female FVB/n mice. Biocatalysis and Agricultura Biotechnology. ISSN 1878-8181. 74, p. 1-12
dc.identifier.doi10.1016/j.bcab.2026.104070
dc.identifier.issn1878-8181
dc.identifier.urihttp://hdl.handle.net/10198/36929
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationResgate de bolotas com um Superalimento Tradicional Mediterrânico - PRIMA/0005/2022
dc.relationCITAB - Centre for the Research and Technology of Agro-Environmental and Biological Sciences
dc.relationInstitute for innovation, capacity building and sustainability of agri-food production
dc.relationCIMO - Mountain Research Center - UID/PRR/00690/2025
dc.relationMountain Research Center - UID/00690/2025
dc.relationAssociate Laboratory for Sustainability and Tecnology in Mountain Regions - LA/P/0007/2020
dc.relationCECAV - Veterinary and Animal Science Research Center
dc.relationVeterinary and Animal Science Research Centre
dc.relationAssociate Laboratory for Animal and Veterinary Sciences
dc.relationMenthol and Thymol loaded in mucoadhesive nanocapsules for the transportation of ornamental fish
dc.relationInvestigação em alimentos e soluções de base biológica - CEECINST/00107/2021/CP2793/CT0002
dc.relation.ispartofBiocatalysis and Agricultural Biotechnology
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBy-products
dc.subjectKidney
dc.subjectLiver
dc.subjectOxidative stress
dc.subjectPolyphenols
dc.subjectQuercus suber
dc.titlePreserved organ function and redox homeostasis following repeated oral exposure to Quercus suber acorn shell extract in female FVB/n miceeng
dc.typejournal article
dspace.entity.typePublication
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oaire.citation.endPage12
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oaire.citation.titleBiocatalysis and Agricultura Biotechnology
oaire.citation.volume74
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