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Chitosan/nanocellulose electrospun fibers with enhanced antibacterial and antifungal activity for wound dressing applications

2021Artigo científico Acesso aberto
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dc.contributor.authorRibeiro, Ana S.
dc.contributor.authorCosta, Sofia M.
dc.contributor.authorFerreira, Diana P.
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorBarros, Lillian
dc.contributor.authorStojković, Dejan
dc.contributor.authorSoković, Marina
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorFangueiro, Raul
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2021-11-22T11:25:59Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2021-11-22T11:25:59Z
dc.date.issued2021
dc.description.abstractThe combination of biodegradable fibers at nanoscale with plant-based extracts is attracting increasing attention to produce wound dressing systems. In this work, nanofibers based on chitosan (CS), poly(ethylene oxide) (PEO), cellulose nanocrystals (CNC) and acacia plant-based extract were developed by electrospinning. Firstly, the polymeric formulations and electrospinning parameters were optimized, resulting in nanofibers with average diameters of 80 nm. CNC were successfully introduced into the optimized CS/PEO blend and the membranes were characterized by FESEM, ATR-FTIR, TGA, XRD, WVTR and WCA. The CNC incorporation improved the nanofibers' physical integrity, morphology, diameters, water vapor transmission rate and thermal properties. After acacia introduction into the best CS/PEO/CNC system, the antibacterial effect was relatively maintained while the antifungal activity was enhanced for some fungi, demonstrating its great effect against a wide range of microorganisms, which is crucial to prevent or treat infections. All the developed systems exhibited absence of cytotoxicity in non-tumor cells, suggesting their biocompatibility. Finally, a continuous release of the acacia extract was observed for 24 h, showing its prolonged action, which contributes to the healing process while reduces the frequency of dressing's replacement. Overall, the developed nanofibers are very promising to act as localized drug delivery systems for wound care applications.en_EN
dc.description.sponsorshipThe authors are thankful to TSSiPRO project, operation code NORTE01-0145-FEDER-000015. The authors are also grateful to FCT, Portugal for financial support through national funds FCT/MCTES to CIMO (UIDB/00690/2020) and to 2C2T (UID/CTM/00264/2019). D. P. Ferreira thank the national funding by FCT through the individual scientific employment program-contract (CEECIND/02803/2017), S. M. Costa thank the FCT PhD Scholarship (SFRH/BD/147517/2019), and L. Barros and R. Calhelha thank the institutional scientific employment program-contract. This work has been supported by the Ministry of Education, Science and Technological Development of Republic of Serbia (451-03-68/2020-14/200007).
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationRibeiro, Ana S.; Costa, Sofia M.; Ferreira, Diana P.; Calhelha, Ricardo C.; Barros, Lillian; Stojković, Dejan; Soković, Marina; Ferreira, Isabel C.F.R.; Fangueiro, Raul (2021). Chitosan/nanocellulose electrospun fibers with enhanced antibacterial and antifungal activity for wound dressing applications. Reactive and Functional Polymers. ISSN 1381-5148. 159, p. 1-10en_EN
dc.identifier.doi10.1016/j.reactfunctpolym.2020.104808en_EN
dc.identifier.issn1381-5148
dc.identifier.urihttp://hdl.handle.net/10198/24239
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationMountain Research Center
dc.relationCentre for Textile Science and Technology
dc.relationSmart, sustainable and innovative materials for personal protection and healthcare based on Natural Fibres and Nanomaterials
dc.relationLocal drug delivery systems based on biodegradable nanofibers for cancer photodynamic therapy PDT
dc.subjectAcacia natural extracten_EN
dc.subjectCellulose nanocrystals (CNC)en_EN
dc.subjectChitosanen_EN
dc.subjectDrug delivery systemsen_EN
dc.subjectElectrospun nanofibersen_EN
dc.titleChitosan/nanocellulose electrospun fibers with enhanced antibacterial and antifungal activity for wound dressing applicationsen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberUIDB/00690/2020
oaire.awardNumberUID/CTM/00264/2019
oaire.awardNumberCEECIND/02803/2017/CP1458/CT0003
oaire.awardNumberSFRH/BD/147517/2019
oaire.awardTitleMountain Research Center
oaire.awardTitleCentre for Textile Science and Technology
oaire.awardTitleSmart, sustainable and innovative materials for personal protection and healthcare based on Natural Fibres and Nanomaterials
oaire.awardTitleLocal drug delivery systems based on biodegradable nanofibers for cancer photodynamic therapy PDT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FCTM%2F00264%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F02803%2F2017%2FCP1458%2FCT0003/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F147517%2F2019/PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamCEEC IND 2017
oaire.fundingStreamPOR_NORTE
person.familyNameCalhelha
person.familyNameBarros
person.familyNameFerreira
person.givenNameRicardo C.
person.givenNameLillian
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifier144781
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-2172-2014
person.identifier.ridJ-3600-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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