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Effects of gamma radiation on phenolic composition, cytotoxicity, antibacterial and virucidal activities of two medicinal plants

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dc.contributor.authorPereira, Eliana
dc.contributor.authorPimenta, Andreia I.
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorAntonio, Amilcar L.
dc.contributor.authorBarros, Lillian
dc.contributor.authorSantos-Buelga, Celestino
dc.contributor.authorCabo Verde, Sandra
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2018-10-29T11:01:54Z
dc.date.available2018-10-29T11:01:54Z
dc.date.issued2018
dc.description.abstractThe consumers' interest for a healthier diet and the use of natural products in the prevention and/or treatment of health problems has triggered an intensive search for bioactive plant compounds. Plants are a good source of phenolic compounds, terpenoids, alkaloids, quinones, carotenoids, sterols, glucosinolates and other compounds, which provide health benefits due to their wide range of biological properties. This work aimed to evaluate the effects of gamma radiation on the phenolic composition, cytotoxicity, virucidal and antimicrobial properties of Aloysia citrodora L. and Mentha x piperita L. infusions. Gamma radiation treatment was performed in a 60Co chamber, applying the doses of 1 and 10 kGy and the results were compared with the control sample (0 kGy). The phenolic compounds profile was obtained by HPLC-DAD-ESI/MS and the cytotoxicity was evaluated in human tumour cell lines and in a primary cell culture. For virucidal efficacy evaluation, MNV-1 and HAdV-5 viral titers were determined by plaque assay in Raw264.7 and A549 cell lines, respectively. The antibacterial activity was evaluated against Gram-negative and Gram-positive bacteria. Radiation treatment has been shown to cause different effects on phenolic concentrations and virucidal efficacy, depending on the plant species studied, the virus and the absorbed dose. In cytotoxicity assay A. citrodora did not reveal significant statistically differences considering the different doses applied, however M. piperita at 10 kGy stood out with the highest cytotoxic potential in all tested cell lines. Regarding antibacterial assays, S. aureus was the only bacteria that was sensible to the infusions of non-irradiated and 1 kGy irradiated in both species. Thus, this study contribute to a wider knowledge of the effects of gamma irradiation on several relevant bioactive potentials of some aromatic and medicinal plants and showed that gamma radiation is a technique recommended for these matrices.pt_PT
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology (FCT, Portugal) and FEDER under Programme PT2020 for financial support to CIMO (UID/AGR/00690/2013) and CTN (RECI/AAG-TEC/0400/2012). The authors are also grateful to FEDER-Interreg España-Portugal programme for financial support through the project 0377_Iberphenol_6_E.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPereira, Eliana; Pimenta, Andreia; Calhelha, Ricardo C.; Antonio, Amilcar L.; Barros, Lillian; Santos-Buelga, Celestino; Cabo Verde, Sandra; Ferreira, Isabel C.F.R. (2018). Effects of gamma radiation on phenolic composition, cytotoxicity, antibacterial and virucidal activities of two medicinal plants. In UNIFood Conference. Belgrado, Sérviapt_PT
dc.identifier.urihttp://hdl.handle.net/10198/18125
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationApplication of Ionizing Radiation for a Sustainable Environment
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectGamma radiation
dc.titleEffects of gamma radiation on phenolic composition, cytotoxicity, antibacterial and virucidal activities of two medicinal plantspt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleApplication of Ionizing Radiation for a Sustainable Environment
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAGR%2F00690%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/RECI%2FAAG-TEC%2F0400%2F2012/PT
oaire.citation.conferencePlaceBelgrado, Sérviapt_PT
oaire.citation.titleUNIFood Conferencept_PT
oaire.fundingStream5876
oaire.fundingStream3599-PPCDT
person.familyNamePereira
person.familyNameCalhelha
person.familyNameAntonio
person.familyNameBarros
person.familyNameFerreira
person.givenNameEliana
person.givenNameRicardo C.
person.givenNameAmilcar L.
person.givenNameLillian
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifier144781
person.identifier.ciencia-idBE17-462D-9A75
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-id1014-5259-DE86
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0003-2854-6745
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0001-8271-9964
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridQ-8017-2018
person.identifier.ridJ-2172-2014
person.identifier.ridJ-1960-2014
person.identifier.ridJ-3600-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id55938912300
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id44560921900
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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